Magnetic hydroxyapatite bisphosphonate-based composites: a bone-targeting nanosystem

Mostafa, Sahar I.; Ismail, Marwa S.; Mohammed, Hagag A.; Osman, Manal F.; El-Wassefy, Noha A.

doi:10.1007/s42247-022-00430-7

Cited by 5 publications

(1 citation statement)

References 57 publications

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“…A variety of magnetic biomaterials are used for bone regeneration, including iron oxide nanoparticles [ 57 ], magnetic hydroxyapatite [ 232 ], magnetic composite [ 236 ], magnetically functionalized scaffolds [ 237 ], and magnetic nanoparticle-labeled cells [ 238 ], facilitating targeted therapies and improved tissue healing through magnetic field manipulation.…”

Section: Magnetic Materials and Stimuli In Regenerative Medicinementioning

confidence: 99%

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest over the last few years for their great potential, offering advanced multi-therapeutic strategies because of their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The most relevant synthetic methods to obtain magnetic apatite-based materials, either in the form of iron-doped HA nanoparticles showing intrinsic magnetic properties or composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles, are described as highlighting structure–property correlations. Following this, this review discusses the application of various magnetic hydroxyapatite nanomaterials in bone regeneration and nanomedicine. Finally, novel perspectives are investigated with respect to the ability of mHA nanoparticles to improve nanocarriers with homogeneous structures to promote multifunctional biological applications, such as cell stimulation and instruction, antimicrobial activity, and drug release with on-demand triggering.

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Section: Magnetic Materials and Stimuli In Regenerative Medicinementioning

confidence: 99%

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

Inam,

Sprio,

Tavoni

et al. 2024

IJMS

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Bone regeneration by hydroxyapatite-gelatin nanocomposites

et al. 2023

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Aim of study:Preparation and characterization of a series of new biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel) and hydroxyapatite-Gelatin-alendronate (HA-Gel-Ald np). Material and methodsIBP nanocomposites were synthesized from mixing different ratios of gelatin to aqueous solutions of both Ca(NO 3 ) 2 .4H 2 O and (NH 4 ) 2 HPO 4 to obtain (HA-Gel np), while the target nanocomposites, HA-Gel-Ald np, were obtained by submitting aqueous solution of alendronate (Ald) to HA-Gel np nanocomposites. These composites crystallinity were analyzed by FTIR and XRD, and their morphology were characterized by scanning electron microscopy (SEM) and EDX measurements. XRD patterns, SEM and EDX presented changes in the crystal and surface structure from HA to HA-Gel np to HA-Gel-Ald np. Furthermore, the cytotoxicity of the nanocomposites on stem cells were assessed using MTT assay. ResultsThe physico-chemical measurements, FTIR, XRD, SEM and EDX indicated the success in isolating the nanocomposites, HA-Gel np and HA-Gel-Ald np, with different ratios. Although the cytotoxicity data show signi cant effect of the prepared IBP nanocomposites (p = 0.00), their interaction together had no signi cant effect (p = 0.624).

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