Magnetic Hyperthermia Properties of Electrosynthesized Cobalt Ferrite Nanoparticles

Abstract

Using the electrochemical route, cobalt ferrite nanoparticles (NPs) with two different sizes were synthesized and stabilized in water by coating with citric acid. The specific absorption rate (SAR) values of aqueous suspensions of magnetic nanoparticles with crystal sizes of 13 and 28 nm were investigated in the frequency range 32−101 kHz and up to 51 mT. SAR values were higher for the larger NPs and reached 133 W/g. Numerical simulations are used for a quantitative analysis of hyperthermia experiments and seem to indicate that the larger NPs are multidomain. Cytotoxicity analysis was also performed in HeLa tumor cells; a null cytotoxicity of these nanoparticles in cell tissues were obtained.

Water dispersible CoFe2O4 nanoparticles with improved colloidal stability for biomedical applications

“…), but the metallic nanoparticles are highly toxic and very sensitive to oxidation and hence are not useful for biomedical applications. Another alternative can be spinel ferrites such as MFe2O4 (M  Co, Mn, Ni) [9,10,11]. Among these ferrites, CoFe2O4 is interesting due to its large curie temperature, high effective anisotropy and moderate saturation magnetization [12].…”

“…Several techniques such as microemulsion [13], coprecipitation [14], ball milling [15], sol−gel [16], thermal decomposition [17], sonochemical [18] and electrosynthesis [9] method have been employed for the synthesis of magnetic nanoparticles but all these synthesis methods often produce larger size nanoparticles with wide particle size distribution.…”

Cobalt Ferrite Nanoparticles Fabricated via Co-precipitation in Air: Overview of Size Control and Magnetic Properties

“…Due to these sources of toxicity, in order to utilize Cobalt Ferrite nanoparticles for medical applications one must coat the particles with a nontoxic, biocompatible coating. Potential biocompatible coatings include certain polymers such as polyethylene glycol (PEG) [30]. Another biocompatible polymer which can be used to coat Cobalt Ferrite is polyvinylpyrrolidone (PVP) [44].…”

“…Hyperthermia is a cancer treatment which involves applying temperatures between 41°C and 45°C to kill cancer cells [29][30][59][60][61]. Typically treatments are applied for at least thirty minutes [30].…”

“…Typically treatments are applied for at least thirty minutes [30]. Hyperthermia treatments can be carried out using magnetic nanoparticles generally and CoFe2O4 nanoparticles in particular, in what is called magnetic hyperthermia [29][30][59][60][61].…”