Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Liu, Hongji; Li, Changwei; Qian, Yong; Hu, Lin; Fang, Jun; Wei, Tong; Nie, Rongrong; Chen, Qianwang; Wang, Hui

doi:10.1016/j.biomaterials.2019.119700

Cited by 159 publications

(121 citation statements)

References 87 publications

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“…At 2 W/cm 2 , the final temperature increase of the dispersion reached 75.5 ° C, suggesting that CNSI dispersions possess efficient photothermal conversion capability, competitive to other carbon nanomaterials. For instance, graphene quantum dots of 0.3 mg/mL showed a temperature increase of about 40 ° C after 5‐minute irradiation at 1.0 W/cm 2 @1064 nm 26 . The dispersion of 0.5 mg/mL Fe 3 O 4 modified graphene was heated from 20 ° C to approximately 60 ° C after 10‐minute irradiation at 1.0 W/cm 2 @805 nm 27 .…”

Section: Resultsmentioning

confidence: 99%

“…Our results collectively indicated that CNSI had large absorption cross‐section, excellent photothermal conversion efficiency and low toxicity, making CNSI suitable for PTT of tumors. The PTT performance of CNSI was competitive to other carbon nanomaterials 10‐12,26,27 . Considering the two main issues hindering the clinical uses of carbon nanomaterials, CNSI had congenital advantages.…”

Section: Resultsmentioning

confidence: 99%

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Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Huang

Zeng

Qian

et al. 2020

MedComm

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Due to the unique structure, carbon nanomaterials could convert near‐infrared (NIR) light into heat efficiently in tumor ablation using photothermal therapy (PTT). Carbon nanoparticles suspension injection (CNSI) is a commercial imaging reagent for lymph node mapping. CNSI has similar structural characteristics to other carbon nanomaterials, and thus, might be applied as photothermal agent. Herein, we evaluated the photothermal conversion ability and therapeutic effects of CNSI on thyroid carcinoma. CNSI was composed by carbon nanoparticle cores and polyvinylpyrrolidone K30 as the dispersion reagent. CNSI absorbed NIR light efficiently following the Lambert‐Beer law. The temperature of CNSI dispersion increased quickly under the NIR irradiation. CNSI killed the TCP‐1 thyroid carcinoma cells under 808 nm laser irradiation at 0.5 W/cm2, while CNSI or NIR irradiation treatment alone did not demonstrate this effect. Temperature increases were observed in tumor injected with CNSI under NIR irradiation. After three irradiation treatments, the tumor growth was completely blocked and the disruption of cellular structure was observed. When the tumor temperatures reached 53°C during treatment, the tumors did not recur within the observation period of 3 months. Our results suggested that CNSI might be used for PTT through “off label” use to benefit the patients immediately.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Huang

Zeng

Qian

et al. 2020

MedComm

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“…PTT can exploit a local heating effect to realize the ablation of cancer tissues by combining light-absorbing materials with NIR light irradiation. The use of NIR light as an external stimulus allows for remote and high spatiotemporal control of local heating, leading to irreversible destruction of cancer tissue 35 . Hyperthermia over 50 °C, followed by NIR light irradiation, can cause irreversible DNA and protein denaturation in cancer regions 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Considering that the tissue penetration depth of light increases with increasing wavelength, the NIR-II biowindow exhibits deeper tissue penetration compared with the NIR-I light. It would be helpful to develop efficient photoresponsive nanomaterials with high NIR-II absorbance 35 , 42 . Recently, a new family of two dimensional (2D) nanomaterials, named MXenes, have generated great interest because of their unique physiochemical performance and excellent photothermal conversion efficiency 53 .…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…Uniform size (3.6 nm), tunable quantum yield (16.67%), and high PTT conversion efficiency (33.45%) were the most important advantages reported by Liu and co-workers. 374 Zheng et al investigated a multifunctional platform composed of GQDs modied with hollow copper sulde nanoparticles (CuSNPs) for controlled intracellular drug release and enhanced PTT-chemotherapy. Initially, the CuSNPs were synthesized and used as an encapsulating agent for Dox.…”

Section: O-dots In Phototherapymentioning

confidence: 99%

Organic dots (O-dots) for theranostic applications: preparation and surface engineering

et al. 2021

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Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Cited by 159 publications

References 87 publications

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinoma in vivo

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Organic dots (O-dots) for theranostic applications: preparation and surface engineering

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