Magnetic iron oxide nanoparticles/10-hydroxy camptothecin co-loaded nanogel for enhanced photothermal-chemo therapy

Li, Wenting; Xue, Bingxin; Shi, Kun; Qu, Ying; Chu, Bingyang; Zhang, Qian

doi:10.1016/j.apmt.2018.11.008

Cited by 36 publications

(22 citation statements)

References 26 publications

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“…[25] Subsequent literatures mentioned that the mechanism of Fe 3 O 4 NPs polarized macrophages was based on the Fenton reaction. [26][27][28][29] Although these studies speculate that Fenton reaction promotes TAMs polarization, there is no more in-depth study to prove this process. At the same time, it was also pointed out that the accumulation of iron in the macrophages could cause the phenotypic switching since Fe 3 O 4 NPs could be internalized by macrophages and degraded to iron ions.…”

Section: The Progress Of Antitumor Immunotherapy Is Usually Limited Bmentioning

confidence: 99%

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Liu

Wang

Guo

et al. 2020

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105

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The progress of antitumor immunotherapy is usually limited by tumor‐associated macrophages (TAMs) that account for the highest proportion of immunosuppressive cells in the tumor microenvironment, and the TAMs can also be reversed by modulating the M2‐like phenotype. Herein, a biomimetic polymer magnetic nanocarrier is developed with selectively targeting and polarizing TAMs for potentiating immunotherapy of breast cancer. This nanocarrier PLGA‐ION‐R837 @ M (PIR @ M) is achieved, first, by the fabrication of magnetic polymer nanoparticles (NPs) encapsulating Fe3O4 NPs and Toll‐like receptor 7 (TLR7) agonist imiquimod (R837) and, second, by the coating of the lipopolysaccharide (LPS)‐ treated macrophage membranes on the surface of the NPs for targeting TAMs. The intracellular uptake of the PIR @ M can greatly polarize TAMs from M2 to antitumor M1 phenotype with the synergy of Fe3O4 NPs and R837. The relevant mechanism of the polarization is deeply studied through analyzing the mRNA expression of the signaling pathways. Different from previous reports, the polarization is ascribed to the fact that Fe3O4 NPs mainly activate the IRF5 signaling pathway via iron ions instead of the reactive oxygen species‐induced NF‐κB signaling pathway. The anticancer effect can be effectively enhanced through potentiating immunotherapy by the polarization of the TAMs in the combination of Fe3O4 NPs and R837.

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Section: The Progress Of Antitumor Immunotherapy Is Usually Limited Bmentioning

confidence: 99%

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Liu

Wang

Guo

et al. 2020

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105

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“…In this regard, it has been attempted to utilize nanomaterials to develop theranostic platforms for the treatment of breast cancer 2 . However, working in various therapeutic areas based on nano-based platforms is a complex and difficult process due to the limited colloidal stability and combined-modality therapy, toxicity, and complex mechanism of NPs in the biological systems [3][4][5] . A better understanding of breast cancer microenvironment, cancer drug resistance, control of drug clearance and drug delivery along with auxiliary therapeutic platforms such as chemotherapy, MF therpay, PTT or their combination have been facilitated the treatment of breast cancer [6][7][8] .…”

mentioning

confidence: 99%

“…The use of PMNSs in photothermal therapeutic platforms has been intensively developed, because these NPs are capable of absorbing magnetic and optical wavelengths that are not commonly absorbed in biological systems. Indeed, the heat induced by absorbing light results in some cellular responses like apoptosis through elevating ROS level 4,5,12 . PMNSs can locally destroy the target site by hyperthermia during MF or PTT activities without inducing significant side effects against adjacent tissues 2 .…”

mentioning

confidence: 99%

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Sharifi

Hasan

Nanakali

et al. 2020

Sci Rep

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The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical properties were examined by FE-SEM, TEM, DLS, TGA, XRD investigations. The cytotoxicity of as-synthesized NPs against 4T1 cells was carried out by MTT and flow cytometry assays. Afterwards, the anti-cancer activities of as-synthesized Lf-Doxo-PMNSs on the tumor status, drug distribution and apoptosis mechanism were evaluated. The anti-cancer assays showed that Lf-Doxo-PMNSs significantly suppressed the cancer cell proliferation and tumor weight by prolonging drug availability and potential drug loading in tumor cells; whereas they showed a minimum cytotoxicity against non-cancerous cells. Likewise, combined chemo-MF-PTT using Lf-Doxo-PMNSs displayed the highest anti-cancer activity followed by combined chemo-PTT and combined chemo-MF therapy based on altering the apoptosis mechanism. Therefore, these results showed that combined chemo-MF-PTT based on Lf-Doxo-PMNSs can be used as a promising therapeutic platform with potential targeted drug delivery and high loading capacity features as well as reducing cancer drug resistance.

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“…Qian et al [ 239 ] prepared a hybrid NG system based on a thermo-responsive co-polymer [ N -isopropylacrylamide, methacrylic acid and poly (ethylene glycol) methacrylate] that stabilizes hydrophobic IONPs and 10-hydroxy camptothecin (HCPT) in its inner compartment. The obtained IONP/HCPT-NG generated an increase in reactive oxygen species (ROS), allowed the enrichment of NG at the tumor site by applying an external magnetic field, and offered the possibility of being used as nanocarrier for photothermal therapy due to its absorption in the near infrared (NIR) range.…”

Section: Functionalization Of Ionpsmentioning

confidence: 99%

“…The obtained IONP/HCPT-NG generated an increase in reactive oxygen species (ROS), allowed the enrichment of NG at the tumor site by applying an external magnetic field, and offered the possibility of being used as nanocarrier for photothermal therapy due to its absorption in the near infrared (NIR) range. In vivo results demonstrated that the combination of PTT and chemotherapy with external magnetic fields on IONP/HCPT-NGs, reduced the growth of primary tumors and prevented metastasis [ 239 ].…”

Section: Functionalization Of Ionpsmentioning

confidence: 99%

Magnetic Nanoparticles as MRI Contrast Agents

et al. 2020

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Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.

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Magnetic iron oxide nanoparticles/10-hydroxy camptothecin co-loaded nanogel for enhanced photothermal-chemo therapy

Cited by 36 publications

References 26 publications

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Magnetic Nanoparticles as MRI Contrast Agents

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