Magnetic Janus micromotors for fluorescence biosensing of tacrolimus in oral fluids

Glahn-Martínez, Bettina; Jurado-Sánchez, Beatriz; Benito-Peña, Elena; Escarpa, Alberto; Moreno-Bondi, María C.

doi:10.1016/j.bios.2023.115796

Biosensors and Bioelectronics

2024

DOI: 10.1016/j.bios.2023.115796

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Magnetic Janus micromotors for fluorescence biosensing of tacrolimus in oral fluids

Bettina Glahn-Martínez,

Beatriz Jurado-Sánchez,

Elena Benito-Peña

et al.

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2024

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Cited by 4 publications

References 44 publications

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Bioactive Materials

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Li,

Dan,

Chen

et al. 2024

Bioactive Materials

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Kim,

Jo,

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Journal of Controlled Release

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Antibody-Based Array for Tacrolimus Immunosuppressant Monitoring with Planar Plastic Waveguides Activated with an Aminodextran-Lipase Conjugate

Glahn-Martínez,

Herranz,

Benito-Peña

et al. 2024

Anal. Chem.

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Cyclic olefin copolymers (COC; e.g., Zeonor, Topas, Arton, etc.) are materials with outstanding properties for developing point-of-care systems; however, the lack of functional groups in their native form makes their application challenging. This work evaluates different strategies to functionalize commercially available Zeonor substrates, including oxygen plasma treatment, photochemical grafting, and direct surface amination using an amino dextran-lipase conjugate (ADLC). The modified surfaces were characterized by contact angle measurements, Fourier transform infrared-attenuated total reflection analysis, and fluorescence assays based on evanescent wave excitation. The bioaffinity activation through the ADLC approach results in a fast, simple, and reproducible approach that can be used further to conjugate carboxylated small molecules (e.g., haptens). The usefulness of this approach has been demonstrated by the development of a heterogeneous fluorescence immunoassay to detect tacrolimus (FK506) immunosuppressant drug using an array biosensor platform based on evanescence wave laser excitation and Zeonor-ADLC substrates. Surface modification with ADLC-bearing FK506 provides a 3D layer that efficiently leads to a remarkably low limit of detection (0.02 ng/mL) and IC50 (0.9 ng/mL) together with a wide dynamic range (0.07−11.3 ng/mL).

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Magnetic Janus micromotors for fluorescence biosensing of tacrolimus in oral fluids

Cited by 4 publications

References 44 publications

Developing fibrin-based biomaterials/scaffolds in tissue engineering

Developing fibrin-based biomaterials/scaffolds in tissue engineering

Biocompatible polymer-based micro/nanorobots for theranostic translational applications

Antibody-Based Array for Tacrolimus Immunosuppressant Monitoring with Planar Plastic Waveguides Activated with an Aminodextran-Lipase Conjugate

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