Magnetic labeling, detection, and system integration

Tamanaha, Cy R.; Mulvaney, Shawn P.; Rife, J. C.; Whitman, L. J.

doi:10.1016/j.bios.2008.02.009

Cited by 190 publications

(123 citation statements)

References 57 publications

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“…and are employed in detecting target biomolecules by binding the probe biomolecules immobilized on the magnetic sensor surface. In the literature, the magnetic sensing bioassay research has mainly focused on improving the limits of detection [1][2][3]. The improvement of the detection limit is attributed to the detection of very weak magnetic fields generated from the small number of conjugated magnetic biolabels (e.g single bead) on the magnetic sensor surfaces [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Single Magnetic Bead Detection in a Microfluidic Chip Using Planar Hall Effect Sensor

Kim¹,

Reddy²,

Kim³

et al. 2014

Journal of Magnetics

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In this study, we fabricate an integrated microfluidic chip with a planar Hall effect (PHE) sensor for single magnetic bead detection. The PHE sensor was constructed with a junction size of 10 µm × 10 µm using a trilayer structure of Ta(3 nm)/NiFe(10 nm)/Cu(1.2 nm)/IrMn(10 nm)/Ta(3 nm). The sensitivity of the PHE sensor was 19.86 µV/Oe. A diameter of 8.18 µm magnetic beads was used, of which the saturation magnetization was ~2.1 emu/g. The magnetic susceptibility χ of these magnetic beads was calculated to bẽ 0.14. The diluted magnetic beads solution was introduced to the microfluidic channel attributing a single bead flow and simultaneously the PHE sensor voltage was measured to be 0.35 µV. The integrated microchip was able to detect a magnetic moment of 1.98 × 10 −10 emu.

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Section: Introductionmentioning

confidence: 99%

Single Magnetic Bead Detection in a Microfluidic Chip Using Planar Hall Effect Sensor

Kim¹,

Reddy²,

Kim³

et al. 2014

Journal of Magnetics

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“…Magnetoresistive-based biochips were first introduced in 1998 by the Naval Research Laboratory (NRL) and since then an increasing number of research laboratories and companies have been developing such systems (Graham et al, 2004;Megens & Prinz, 2005;Tamanaha et al, 2008;Xu et al, 2008, Martinsa et al, 2009). The use of small magnetic particles or beads in biomedical sciences has increased significantly in recent years (Haukanes & Kvam, 1993).…”

Section: Gmr For Biosensing Applicationsmentioning

confidence: 99%

Electromagnetic sensor technology for biomedical applications

Panina¹

2011

Recent Application in Biometrics

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“…The systems based on magnetic approaches hold promising perspectives due to their miniaturization possibility [4,5]. Some attempts have been made in order to embed magnetic sensors such as GMR, TMR, and planar Hall Effect sensors [6]. The LOC pathogen sensing system should be sensitive with a low limit of detection, cost effective, size selective, simple to use and with a large dynamic range.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results

Rabehi¹,

Garlan²,

Shanehsazzadeh

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:The aim of this work is to develop a completely integrated Lab-On-Chip (LOC) for easy, rapid and cost-effective immunoassays. The pathogen sensing system is composed of a microfluidic channel surrounded by planar microcoils which are responsible for the emission and the detection of magnetic fields. The system allows the detection and quantification of superparamagnetic beads used for immunoassays in a "sandwich" antigen-antibody configuration. Multiphysics simulations have been achieved and preliminary experimental results have allowed to validate the structure.

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Magnetic labeling, detection, and system integration

Cited by 190 publications

References 57 publications

Single Magnetic Bead Detection in a Microfluidic Chip Using Planar Hall Effect Sensor

Single Magnetic Bead Detection in a Microfluidic Chip Using Planar Hall Effect Sensor

Electromagnetic sensor technology for biomedical applications

Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results

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