Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Xuan, Mingjun; Shao, Jianzhong; Zhao, Jie; Li, Qi; Dai, Luru; Li, Junbai

doi:10.1002/anie.201712996

Cited by 266 publications

(155 citation statements)

References 44 publications

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“…2019, 6, 1802001 and free ICG (Figure 6e). [14,45] Quantitative analysis of the ICG fluorescence intensity distribution in the organs and tumor is shown in Figure S15 of the Supporting Information, and is in agreement with the ex vivo fluorescence imaging. These results confirmed that ICG/PFP@ HMOP-PEG could effectively extend the blood circulation time of ICG due to the PTX prodrug capping and PEGylation.…”

Section: In Vivo Pharmacokinetics and Biodistributionsupporting

confidence: 77%

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

Williams

Niu

et al. 2019

Advanced Science

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Theranostic formulations, integrating both diagnostic and therapeutic functions into a single platform, hold great potential for precision medicines. In this work, a biodegradable theranostic based on hollow mesoporous organosilica nanoparticles (HMONs) is reported and explored for ultrasound/photoacoustic dual‐modality imaging guided chemo‐photothermal therapy of cancer. The HMONs prepared are endowed with glutathione‐responsive biodegradation behavior by incorporating disulfide bonds into their framework. The nanoparticles are loaded with indocyanine green (ICG) and perfluoropentane (PFP). The former acts as a photothermal agent and the latter can generate bubbles for ultrasound imaging. A paclitaxel prodrug is developed to both serve as a redox‐sensitive gatekeeper controlling ICG release from the HMON pores and a chemotherapeutic. ICG generates mild hyperthermia upon exposure to an 808 nm laser, and this in turn leads to a liquid–gas phase transition of PFP, resulting in the generation of bubbles which can be used for ultrasound imaging. The platform is found to have excellent properties for both ultrasound and photoacoustic imaging. In addition, both in vitro and in vivo results show that the nanoparticles provide potent synergistic chemo‐photothermal therapy. The material developed in this work thus has great potential for exploitation in advanced cancer therapies.

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Section: In Vivo Pharmacokinetics and Biodistributionsupporting

confidence: 77%

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

Williams

Niu

et al. 2019

Advanced Science

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“…Similarly, in PDT, photosensitizers are delivered into tumors, and subsequent irradiation of the tumor causes the photosensitizer to transfer the absorbed energy to adjacent tissue oxygen molecules, producing toxic singlet oxygen that destroys cancer cells [89]. While there are some examples of membrane-wrapped NPs being used strictly for PTT or PDT to treat cancer [70,[93][94][95][96][97][98], these singular treatments use non-cancer cell membranes. When cancer cell membranes are used for wrapping, they are commonly studied in combination with other therapeutic strategies, such as drug delivery.…”

Section: Photothermal and Photodynamic Therapymentioning

confidence: 99%

Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Harris

Scully

Day

2019

Cancers

188

125

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Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable of targeting only cancer cells within tumors and metastases post administration. There is a desperate need for targeted therapies that can maximize treatment success and minimize toxicity. Nanoparticles (NPs) with tunable physicochemical properties have potential to meet the need for high precision cancer therapies. At the forefront of nanomedicine is biomimetic nanotechnology, which hides NPs from the immune system and provides superior targeting capabilities by cloaking NPs in cell-derived membranes. Cancer cell membranes expressing "markers of self" and "self-recognition molecules" can be removed from cancer cells and wrapped around a variety of NPs, providing homotypic targeting and circumventing the challenge of synthetically replicating natural cell surfaces. Compared to unwrapped NPs, cancer cell membrane-wrapped NPs (CCNPs) provide reduced accumulation in healthy tissues and higher accumulation in tumors and metastases. The unique biointerfacing capabilities of CCNPs enable their use as targeted nanovehicles for enhanced drug delivery, localized phototherapy, intensified imaging, or more potent immunotherapy. This review summarizes the state-of-the-art in CCNP technology and provides insight to the path forward for clinical implementation.

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“…In the case of stem cells, the targeting capacity was demonstrated employing upconversion (UCN) core@shell-MSNs protocells for photodynamic therapy (PDT) [107]. In the same way, red blood cells' membranes were also employed for cloaking effect, obtaining again outstanding results enabled only by the effect of passive targeting [108].…”

Section: Biological Membranes In Targetingmentioning

confidence: 99%

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Castillo

Lozano

González

et al. 2019

Expert Opinion on Drug Delivery

145

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Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This review summarizes the scientific advances dealing with MSNs for targeted and stimuli-responsive drug delivery since 2015. Delivery aspects to diseased tissues together with approaches to obtain smart MSNs able to respond to internal or external stimuli and their applications are here described. Special emphasis is done on the combination of two or more stimuli on the same nanoplatform and on combined drug therapy. Expert opinion: The use of MSNs in nanomedicine is a promising research field because they are outstanding platforms for treating different pathologies. This is possible thanks to their structural, chemical, physical and biological properties. However, there are certain issues that should be overcome to improve the suitability of MSNs for clinical applications. All materials must be properly characterized prior to their in vivo evaluation; furthermore, preclinical in vivo studies need to be standardized to demonstrate the MSNs clinical translation potential.

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Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Cited by 266 publications

References 44 publications

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

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