Magnetic modulation of the unbraiding dynamics of pairs of DNA molecules to model the system as an intermittent oscillator

Martínez-Santiago, Carlos J.; Quiñones, Edwin

doi:10.1016/j.chemphys.2017.12.018

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“…Recent work using an oscillating MT method estimated braid torques to be ~500 pNꞏnm, much larger than the torques reported here. This difference may be due to the large intertether distances, or the intrinsically non-equilibrium nature of the oscillating MT approach [32].…”

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confidence: 99%

Measurement of the torque in braided DNAs using a thermodynamic Maxwell relation

Xiao

Brahmachari

Liu

et al. 2020

Preprint

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Braided DNAs are significant structural intermediates in cellular processes, yet little has been experimentally demonstrated about their higher-order structure and twisting torques. We use magnetic tweezers to measure braid extensions at forces ranging from 0.3 to 8 piconewtons, and then apply a thermodynamic Maxwell relation to calculate the torque. Experimentally inferred torques in unbuckled braids take on values up to 76 pNꞏnm, which depends on force, and inter-tether distance. As predicted using a statistical mechanical model, the twist modulus of the braids increases with catenation prior to buckling or formation of plectoneme, and is comparable to that of single DNA.

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confidence: 99%