Magnetic molecularly imprinted electrochemical sensors: A review

Yang, Yukun; Yan, Wenyan; Guo, Caixia; Jin-hua, Zhang; Yu, Ligang; Zhang, Guohua; Wang, Xiaomin; Fang, Guozhen; Sun, Dandan

doi:10.1016/j.aca.2020.01.044

Cited by 87 publications

(27 citation statements)

References 108 publications

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“…The response profile by SWV of mag-MIP/CPE and mag-NIP/CPE in the presence of 1.0 mmol L −1 of amoxicillin at 0.72 V vs. Ag/AgCl is shown in Figure 5. The remarkable difference between mag-MIP and mag-NIP sensors is revealed and could be attributed to the presence of the selective cavities in the mag-MIP which increased the sensitivity in the amoxicillin detection, this behavior is also outlined in literature by other authors (Montoya et al, 2015;Yang et al, 2020). The expected profile of the nonselective polymer (mag-NIP/CPE) and CPE (electrode carbon paste) was not satisfactory as compared to magnetic selective polymer (mag-MIP/CPE).…”

Section: Development Of the Electrochemical Sensor Modified With Mag-mipmentioning

confidence: 75%

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

et al. 2021

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This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a β-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N′-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 μmol L−1 of amoxicillin (r2 = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 μmol L−1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples.

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Section: Development Of the Electrochemical Sensor Modified With Mag-mipmentioning

confidence: 75%

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

et al. 2021

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“…MIPs have been identified as another substitute for antibodies, due to their advantages of low cost, high chemical stabilities, and specific recognition [85]. The conventional procedures for MIP fabrication involve the polymerization of templates and functional monomers in the presence of cross-linkers.…”

Section: Rapid Multi-residue Detection Methods Based On Molecularly Imentioning

confidence: 99%

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

et al. 2020

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The excessive use or abuse of pesticides and veterinary drugs leads to residues in food, which can threaten human health. Therefore, there is an extremely urgent need for multi-analyte analysis techniques for the detection of pesticide and veterinary drug residues, which can be applied as screening techniques for food safety monitoring and detection. Recent developments related to rapid multi-residue detection methods for pesticide and veterinary drug residues are reviewed herein. Methods based on different recognition elements or the inherent characteristics of pesticides and veterinary drugs are described in detail. The preparation and application of three broadly specific recognition elements—antibodies, aptamers, and molecular imprinted polymers—are summarized. Furthermore, enzymatic inhibition-based sensors, near-infrared spectroscopy, and SERS spectroscopy based on the inherent characteristics are also discussed. The aim of this review is to provide a useful reference for the further development of rapid multi-analyte analysis of pesticide and veterinary drug residues.

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“…Up to now, several nano/macro materials have been applied for the fabrication of electrochemical MIP-based sensors such as gold nanoparticles ( Motia et al, 2020 ), magnetic nanoparticles ( Yang et al, 2020 ), graphene ( Liang et al, 2017 ; Liu et al, 2019 ), carbon nanotubes ( Meng et al, 2019 ), and Three-dimensional-ensembles of gold nanowires ( Beluomini et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

An ultrasensitive molecularly imprinted polymer-based electrochemical sensor for the determination of SARS-CoV-2-RBD by using macroporous gold screen-printed electrode

Tabrizi

Fernandéz‐Blázquez

Medina

et al. 2022

Biosensors and Bioelectronics

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Herein, a novel molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of the receptor-binding domain of SARS-CoV-2-RBD (SARS-CoV-2-RBD) has been developed. For this purpose, first, a macroporous gold screen-printed electrode (MP-Au-SPE) has been fabricated. The MIP was then synthesized on the surface of the MP-Au-SPE through the electro-polymerization of ortho-phenylenediamine in the presence of SARS-CoV-2-RBD molecules as matrix polymer, and template molecules, respectively. During the fabrication process, the SARS-CoV-2-RBD molecules were embedded in the polymer matrix. Subsequently, the template molecules were removed from the electrode by using alkaline ethanol. The template molecules removal was studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), and attenuated total reflectance spectroscopy (ATR). The fabricated MIP film acted as an artificial recognition element for the measurement of SARS-CoV-2-RBD. The EIS technique was used for the measurement of the SARS-CoV-2-RBD in the saliva solution. The electron transfer resistance (R et ) of the MIP-based sensor in a ferri/ferrocyanide solution increased as the SARS-CoV-2-RBD concentration increased due to the occupation of the imprinted cavities by the SARS-CoV-2-RBD. The MIP-based sensor exhibited a good response to the SARS-CoV-2-RBD in the concentration range between 2.0 and 40.0 pg mL -1 with a limit of detection of 0.7 pg mL -1 . The obtained results showed that the fabricated MIP sensor has high selectivity sensitivity, and stability.

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Magnetic molecularly imprinted electrochemical sensors: A review

Cited by 87 publications

References 108 publications

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples

Rapid Multi-Residue Detection Methods for Pesticides and Veterinary Drugs

An ultrasensitive molecularly imprinted polymer-based electrochemical sensor for the determination of SARS-CoV-2-RBD by using macroporous gold screen-printed electrode

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