Magnetic nano-particles retrievable biodegradable hydrogel microrobot

Kim, Dongin; Lee, Hyoryong; Kwon, Soon Man; Choi, Hyun‐Chul; Park, Sukho

doi:10.1016/j.snb.2019.03.030

Cited by 69 publications

(68 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Known to mankind for millennia, gelatin evolved from naturally derived glue to a widely used material in photographic films, food production, cosmetics and medications 30 . More recently, applications of gelatin span a diverse field from drug delivery 31 , bone tissue engineering 32 , including 3D printed scaffolds 33 and (micro)robotics 34 operating in vivo. Yet so far, gelatin-based gels have moderate performance when strained and rapidly dry when operated in air, which causes stiffening and limits stability and durability of wearable soft devices or soft robotic elements ( Table 1, Supplementary Table 1, Supplementary Table 2).…”

mentioning

confidence: 99%

Resilient yet entirely degradable gelatin-based biogels for soft robots and electronics

et al. 2020

View full text Add to dashboard Cite

Biodegradable and biocompatible elastic materials for soft robotics, tissue engineering or stretchable electronics with good mechanical properties, tunability, modifiability, or healing properties drive technological advance, yet they are not durable under ambient conditions nor combine all attributes in a single platform. We have developed a versatile gelatin-based biogel, which is highly resilient with outstanding elastic characteristics yet degrades fully when disposed. It self-adheres, is rapidly healable and derived entirely from natural and food-safe constituents. We merge for the first time all favorable attributes in one material that is easy to reproduce, scalable and low-cost in production under ambient conditions. This biogel is a step towards durable, lifelike soft robotic and electronic systems that are sustainable and closely mimic their natural antetypes. Main: In 2025, an estimated 6 million tons of garbage will be generated per day 1 , with tech disposables being a rapidly growing contributor. End-of-lifetime appliances contain valuable materials that are laborious in recovery or toxic substances that are readily released into nature through landfilling or improper treatment 2. Biodegradable 3-6 and transient systems 7 are promising routes towards closing the loop on waste generation and create new opportunities for secure systems, but often at the cost of compromises in performance. Complex biological systems bridge this gap. They unite seemingly antagonistic properties-tough yet adaptive, durable and self-healing yet degradable-allowing them to perform a myriad of intricate tasks. Embodiments of technologies that intimately interface with humans naturally benefit from mimicking such soft, functional forms. A range of biomimetic systems 8 including soft machines 9 and electronic skins 10 achieve a high level of functionality by introducing self-healing 11,12 , intrinsic stretchability 13 , or the insightful merging of soft-to-hard materials 14. Waste flow issues and in vivo applications that avoid multiple surgeries are tackled with inextensible devices in the form of edible 3,15 and transient electronics 7,16. However, introducing stretchability to degradable devices remains challenging. Recent approaches focusing on stretchable biodegradable sensors 5 require expensive materials and are still wired to bulky measurement systems hindering implementation as wearable devices. Challenges here stem from the diverse material requirements,

show abstract

mentioning

confidence: 99%

Resilient yet entirely degradable gelatin-based biogels for soft robots and electronics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Only the PLGA-DOX drug particles remain in the target area for the generation of the therapeutic effect, while the MPs are recovered by the magnetic field of the EMA system (Figure 9). The hydrogel-based microrobot forms spherical microbeads and consists of gelatin/PVA hydrogel, PLGA-DOX drug particles and MNPs [92].…”

Section: Drug Deliverymentioning

confidence: 99%

“…(a) Structure of hydrogel microrobot, consisting of gelatin/polyvinyl alcohol (PVA) hydrogel, PLGA-DOX (poly(lactic-co-glycolic acid)-doxorubicin) drug nanoparticles and MNPs (magnetic nanoparticles); (b) concept of the treatment process using hydrogel microrobot, where (i) hydrogel microrobot moves to a target lesion using magnetic field, (ii) hydrogel microrobot is decomposed by NIR (near-infrared) irradiation, (iii) remaining MNPs are retrieved by magnetic field, and (iv) cancer cells are treated by the remaining PLGA-DOX drug particles. Reprinted with permission from Elsevier[92].…”

mentioning

confidence: 99%

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

View full text Add to dashboard Cite

During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

show abstract

“…[ 42–44 ] Despite the fact that microrobots used for biomedical application are made of biocompatible and biodegradable materials, they can cause a potential life‐threatening condition (e.g., vessel embolism) if they are left inside the human body. [ 45 ] To deal with post complications of microrobot remaining inside the target site after functioning, some efforts demonstrated the microrobot retrieval trials. [ 34,46 ] Unfortunately, the completed procedure for in vivo application remains opened in which only a simple in vitro retrieval of microrobots under magnetic guidance is implemented.…”

Section: Introductionmentioning

confidence: 99%

A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval

Nguyen

Jin

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Targeted drug delivery using a microrobot is a promising technique capable of overcoming the limitations of conventional chemotherapy that relies on body circulation. However, most studies of microrobots used for drug delivery have only demonstrated simple mobility rather than precise targeting methods and prove the possibility of biodegradation of implanted microrobots after drug delivery. In this study, magnetically guided self‐rolled microrobot that enables autonomous navigation‐based targeted drug delivery, real‐time X‐ray imaging, and microrobot retrieval is proposed. The microrobot, composed of a self‐rolled body that is printed using focused light and a surface with magnetic nanoparticles attached, demonstrates the loading of doxorubicin and an X‐ray contrast agent for cancer therapy and X‐ray imaging. The microrobot is precisely mobilized to the lesion site through automated targeting using magnetic field control of an electromagnetic actuation system under real‐time X‐ray imaging. The photothermal effect using near‐infrared light reveals rapid drug release of the microrobot located at the lesion site. After drug delivery, the microrobot is recovered without potential toxicity by implantation or degradation using a magnetic‐field‐switchable coiled catheter. This microrobotic approach using automated control method of the therapeutic agents‐loaded microrobot has potential use in precise localized drug delivery systems.

show abstract

Magnetic nano-particles retrievable biodegradable hydrogel microrobot

Cited by 69 publications

References 71 publications

Resilient yet entirely degradable gelatin-based biogels for soft robots and electronics

Resilient yet entirely degradable gelatin-based biogels for soft robots and electronics

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval

Contact Info

Product

Resources

About