Magnetic Nanocolloids

Rivas, José

doi:10.1016/b978-0-12-801578-0.00003-5

Cited by 5 publications

(2 citation statements)

References 196 publications

(96 reference statements)

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“…The recent run of industrial development, in particular nanotechnology, has openedup new possibilities for medical science, especially in the field of magnetic hyperthermia. New superparamagnetic nanoparticle systems of varying nanoscales have been developed and integrated into magnetic hyperthermia ( Figure 1) [1][2][3]. The number of patents and products in the field of magnetic hyperthermia is also growing rapidly.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

Zhao

Lee

2021

Applied Sciences

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The main treatments for cancer recorded to date include chemotherapy, radiotherapy, and surgery. Although we have achieved great success in treating certain types of tumors, there are still many incurable even with the help of modern treatments. Currently, the principles of magnetic-induction hyperthermia in magnetic nanoparticle hyperthermia are considered an effective treatment for cancer cells. As reported in previous articles, these nanoparticles generate a lot of heat that raises the temperatures of tumors, hence treating the cancer cells. The other significant potential of magnetic nanoparticles is the ability to combine heat and drug release for cancer treatment. However, within the biologically safe range of AC magnetic fields, the lack of induction heating power and the high criteria for biocompatibility in superparamagnetic-nanoparticle hyperthermia agents still make up the key challenges for the successful clinical application of magnetic hyperthermia. In this study, two different types of iron oxide nanoparticles (γ-Fe2O3, Fe3O4) were modified with whey protein isolate (WPI) to form bio-modified superparamagnetic nanoparticles with spherical or diamond-shaped structures and diameters between 20 and 100 nm, which demonstrate excellent stability under different conditions. Adriamycin (ADM) has also been successfully loaded onto these nanoparticles and used in this experiment. In vitro and in vivo experimental studies were performed using these WPI-modified nanoparticles on HepG2 tumor models and mice to assess their bioavailability and biological feasibility. The results prove that these WPI-modified nanoparticles perform satisfactorily in conjunction with hyperthermia to cure tumors completely.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

Zhao

Lee

2021

Applied Sciences

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“…On the one hand, the T 1 performance is mainly associated with a paramagnetic character of the contrast agent coming from transition and lanthanide metal ions within their chemical structure presenting a large number of unpaired electrons [ 50 , 51 ]. On the other hand, a T 2 behavior involves a long-range magnetic interaction with water molecules that it is caused by the magnetic field that a superparamagnetic core is able to induce under an applied magnetic field [ 52 ]. In GbMNPs hybrids, the observed shortening in the transverse relaxation time ( T 2 ) [ 4 ] comes from the MNPs counterpart, since the graphene component does not exhibit intrinsic paramagnetism or superparamagnetism [ 53 , 54 , 55 ].…”

Section: Graphene-based Magnetic Nanoparticles For Theranosticsmentioning

confidence: 99%

Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

et al. 2021

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The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic performance of magnetic nanoparticles with the unique properties of graphene-based materials, such as large surface area for functionalization, high charge carrier mobility and high chemical and thermal stability. This hybrid nanosystems aims toward a synergistic theranostic effect. Here, we focus on the most recent developments in GbMNPs for theranostic applications. Particular attention is given to the synergistic effect of these composites, as well as to the limitations and possible future directions towards a potential clinical application.

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