Magnetic Nanocomposites and Their Incorporation into Higher Order Biosynthetic Functional Architectures

Watt, John; Collins, Aaron M.; Vreeland, Erika C.; Montaño, Gabriel A.; Huber, Dale L.

doi:10.1021/acsomega.7b02031

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…The length of the 1D nanochain is tunable when adjusting the contour lengths. Except for the nanochain structure, other architectures such as worm-, wire- − and ring-like nanostructures are reported in other literature studies. In addition to these 1D linear structures, MNPs could also form 2D arrays and gels mainly based on the species of polymer templates.…”

Section: Assembly Of Magnetic Nanostructure Directed By Polymersmentioning

confidence: 99%

Polymer-Assisted Magnetic Nanoparticle Assemblies for Biomedical Applications

Wang

Huang

et al. 2019

ACS Appl. Bio Mater.

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Magnetic nanoparticle (MNP) assemblies have demonstrated great potential in biomedical applications due to their controllable magnetic properties and collective functions. Among the versatile approaches to obtaining MNP assemblies, polymer-assisted assembling methods offer unique advances, by which the assembled nanostructures could exert the merits of both the inorganic magnetic nanoparticles and organic polymeric materials to realize combined advantages for medical diagnosis and treatment. Precise control over the interactions among different building moieties and spatial organization of magnetic nanoparticles with the aid of polymers provides promising strategies in manipulating the physical, chemical, and biological properties of nanoassemblies for biomedical applications. In this review, we summarize the recent progress of polymer-assisted MNP assemblies, which include the mutual interactions between building blocks, architectural diversity of the assemblies, and their synthetic strategies along with biomedical applications. The current review provides a comprehensive insight into controlled and intelligent nanomedicines, which shall facilitate the development of next-generation high-performance theranostic agents based on MNP assemblies.

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Section: Assembly Of Magnetic Nanostructure Directed By Polymersmentioning

confidence: 99%

Polymer-Assisted Magnetic Nanoparticle Assemblies for Biomedical Applications

Wang

Huang

et al. 2019

ACS Appl. Bio Mater.

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“…This study focuses on micelles of a short-chain ABC, polybutadiene- block -poly(acrylic acid) (pBd–pAA). Short-chain (low molecular weight) ABCs are of particular interest for their ability to assemble biomimetic polymer membranes, , hybrid lipid/polymer bilayers, and complex membrane-bound architectures. − Because integration of stimulus response into these biomimetic materials is highly promising for applications such as controlled release, a comprehensive understanding of the behavior of such stimulus-responsive short-chain ABC nanostructures is necessary.…”

Section: Introductionmentioning

confidence: 99%

Complex pH-Dependent Interactions between Weak Polyelectrolyte Block Copolymer Micelles and Molecular Fluorophores

et al. 2022

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Amphiphilic block copolymers with weak polyelectrolyte blocks can assemble stimulus-responsive nanostructures and interfaces. Applications of these materials in drug delivery, biomimetics, and sensing largely rely on the well-understood swelling of polyelectrolyte chains upon deprotonation, often induced by changes in pH or ionic strength. This deprotonation can also tune interfacial interactions between the polyelectrolyte blocks and surrounding solution, an effect which is less studied than morphological swelling of polyelectrolytes but can be just as critical for intended function. Here, we investigate whether the pH-driven morphological response of polyelectrolyte-bearing nanostructures also affects the interactions of these nanostructures with molecules in solution, using micelles of a short-chain polybutadiene-block-poly(acrylic acid) (pBd−pAA) as a model system. We introduce a Forster resonance energy transfer (FRET) approach to probe interactions between micelles and fluorescent molecular solutes as a function of solution pH. As expected, the pAA corona of these pBd−pAA micelles increases in thickness monotonically as a function of pH. However, FRET efficiency, which provides a metric of the spatial proximity of fluorescently labeled micelles and freely diffusing fluorophores, exhibits complex nonmonotonic behavior as a function of pH, indicating that the average separation of micelles and acceptor fluorophores is not strictly correlated with micelle swelling. Dialysis experiments quantify the affinity of fluorophores for micelles as a function of pH, confirming that changes in FRET are driven almost entirely by the pH-dependent affinity of the pAA block for the investigated molecular fluorophores, not simply by a shape change of the pAA corona. This study provides key insights into the interfacial interactions between weak-polyelectrolyte-bearing nanostructures and molecular solutes, of importance for the development of their stimulus-responsive applications.

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