Magnetic Nanomaterials for Arterial Embolization and Hyperthermia of Parenchymal Organs Tumors: A Review

Smolková, Ilona S.; Babayan, Vladimir; Vilčáková, Jarmila; Smolka, Petr; Sáha, Petr

doi:10.3390/nano11123402

Cited by 12 publications

(5 citation statements)

References 130 publications

(233 reference statements)

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“…In addition, if hyperthermic heating of cells is insufficient, polymer coatings with higher critical temperatures can also be designed to release endotoxins by heating the particles with an alternating magnetic field, thereby providing additional targeted killing for drug delivery ( 96 , 97 ).…”

Section: Practical Application Of Af Treatment Methods Based On Nano ...mentioning

confidence: 99%

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

Wang

Tong

et al. 2022

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) is one of the most common sustained tachyarrhythmias worldwide, and its prevalence is positively correlated with aging. AF not only significantly reduces the quality of life of patients but also causes a series of complications, such as thromboembolism, stroke, and heart failure, increases the average number of hospitalizations of patients, and places a huge economic burden on patients and society. Traditional drug therapy and ablation have unsatisfactory success rates, high recurrence rates, and the risk of serious complications. Surgical treatment is highly traumatic. The nano drug delivery system has unique physical and chemical properties, and in the application of AF treatment, whether it is used to assist in enhancing the ablation effect or for targeted therapy, it provides a safer, more effective and more economical treatment strategy.

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Section: Practical Application Of Af Treatment Methods Based On Nano ...mentioning

confidence: 99%

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

Wang

Tong

et al. 2022

Front. Cardiovasc. Med.

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“…Magnetic nanomaterials with MR imaging capabilities could enhance the efficacy of liver chemoembolization ( Pouponneau et al, 2014 ). Studies have shown that magnetic nanomaterials were used for hyperthermia under the stimulation of an external magnetic field ( Kazantseva et al, 2021 ). At the same time, the specific modification of nanomaterials not only improved the specificity and effect of treatment but also reduced the damage to surrounding tissues ( Patra et al, 2018 ).…”

Section: The Advantage Of the Imageable Nanomaterialsmentioning

confidence: 99%

The Advances and Biomedical Applications of Imageable Nanomaterials

Xiang

Shi²,

Gao³

2022

Front. Bioeng. Biotechnol.

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Nanomedicine shows great potential in screening, diagnosing and treating diseases. However, given the limitations of current technology, detection of some smaller lesions and drugs’ dynamic monitoring still need to be improved. With the advancement of nanotechnology, researchers have produced various nanomaterials with imaging capabilities which have shown great potential in biomedical research. Here, we summarized the researches based on the characteristics of imageable nanomaterials, highlighted the advantages and biomedical applications of imageable nanomaterials in the diagnosis and treatment of diseases, and discussed current challenges and prospects.

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“…Typically, SPION emulsions in lipiodol or its derivatives are used for therapeutic processes. Temperatures in the range of 41–45 °C were obtained during previously published studies [ 15 ]. Recently it has been discovered that external ionizing radiation in combination with magnetic hyperthermia has a significantly greater (synergetic) effect on killing various cancer cells than using the two methods separately [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

Gharibkandi

Żuk

Müftüler

et al. 2023

IJMS

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This study was performed to synthesize a radiopharmaceutical designed for multimodal hepatocellular carcinoma (HCC) treatment involving radionuclide therapy and magnetic hyperthermia. To achieve this goal, the superparamagnetic iron oxide (magnetite) nanoparticles (SPIONs) were covered with a layer of radioactive gold (198Au) creating core–shell nanoparticles (SPION@Au). The synthesized SPION@Au nanoparticles exhibited superparamagnetic properties with a saturation magnetization of 50 emu/g, which is lower than reported for uncoated SPIONs (83 emu/g). Nevertheless, the SPION@Au core–shell nanoparticles showed a sufficiently high saturation magnetization value which allows them to reach a temperature of 43 °C at a magnetic field frequency of 386 kHz. The cytotoxic effect of nonradioactive and radioactive SPION@Au–polyethylene glycol (PEG) bioconjugates was carried out by treating HepG2 cells with various concentrations (1.25–100.00 µg/mL) of the compound and radioactivity in range of 1.25–20 MBq/mL. The moderate cytotoxic effect of nonradioactive SPION@Au-PEG bioconjugates on HepG2 was observed. The cytotoxic effect associated with the β− radiation emitted by 198Au was much greater and already reaches a cell survival fraction below 8% for 2.5 MBq/mL of radioactivity after 72 h. Thus, the killing of HepG2 cells in HCC therapy should be possible due to the combination of the heat-generating properties of the SPION-198Au–PEG conjugates and the radiotoxicity of the radiation emitted by 198Au.

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Magnetic Nanomaterials for Arterial Embolization and Hyperthermia of Parenchymal Organs Tumors: A Review

Cited by 12 publications

References 130 publications

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

The Advances and Biomedical Applications of Imageable Nanomaterials

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

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