Magnetic Nanoparticle-Driven and Exosome-Mediated Intelligent Targeting Nanovesicles for Inducing Ferroptosis to Surmount Breast Cancer

Zhu, Maoshu; Li, Yongwu; Huang, Chaoqun; Wu, Xinhong; Lü, Junhong; Lin, Pingli; Su, Ling; Shen, Meikun; Wang, Yun; Zhang, Jianli; Liang, Jianwei; Zhong, Weimin

doi:10.1021/acsanm.3c01304

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…The use of nanoparticles (NPs) in cancer therapy offers several advantages, including enhanced drug delivery, improved targeting, and reduced systemic toxicity [9][10][11][12][13]. NPs can be designed to specifically target cancer cells, thereby increasing the therapeutic efficacy and minimizing off-target effects [11,12,14,15]. Furthermore, NPs can be engineered to trigger ferroptosis, providing a novel strategy for cancer treatment [10].…”

Section: Introductionmentioning

confidence: 99%

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Ensoy,

Ozturk,

Cansaran-Duman

et al. 2024

J. Phys. Mater.

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The use of nanomaterials for cancer ferroptosis presents a promising avenue for research and clinical applications. The unique properties of nanomaterials, such as their small size, large surface area, and ability to be engineered for specific tasks, make them ideal candidates for ferroptosis inducing cancer therapies. Ferroptosis is a new type of cell death mechanism that is distinct from apoptosis and necrosis. It has been shown to be critical in the treatment of various tumors. The ferroptotic mechanism has been mainly linked with the regulation of iron, amino acid, glutathione, and lipid metabolism of cells. The relationship between ferroptosis mechanisms and cancer nanomedicine has attracted considerable interest in recent years. It has been reported that the combination of nanomedicine and ferroptosis can achieve high therapeutic efficacy for the treatment of different cancer types. This review will provide an overview of recent work in ferroptosis-related cancer nanomedicine. First, general information is given about the definition of ferroptosis and its differences from other cell death mechanisms. Later, studies exploring the role of ferroptosis in the cancer nanomedicine field are discussed in detail. Specific focus has been given to the use of combinatorial treatment strategies which combine ferroptosis with chemodynamic therapy, photodynamic therapy, photothermal therapy, immunotherapy and sonodynamic therapy. Considering the fact that ferroptosis inducing nanoparticles have already been introduced into clinical studies, nanoscientists can further accelerate this clinical translation as they tailor the physicochemical characteristics of nanomaterials. This review provides enlightening information for all researchers interested in the molecular characterization and relationship between ferroptosis and cancer-directed nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Ensoy,

Ozturk,

Cansaran-Duman

et al. 2024

J. Phys. Mater.

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Biomaterial‐Mediated Metabolic Regulation of Ferroptosis for Cancer Immunotherapy

Liu,

Tao,

et al. 2024

WIREs Nanomed Nanobiotechnol

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Ferroptosis is a lipid peroxidation‐driven cell death route and has attracted enormous interest for cancer therapy. Distinct from other forms of regulated cell death, its process is involved with multiple metabolic pathways including lipids, bioenergetics, iron, and so on, which influence cancer cell ferroptosis sensitivity and communication with the immune cells in the tumor microenvironment. Development of novel technologies for harnessing the ferroptosis‐associated metabolic regulatory network would profoundly improve our understanding of the immune responses and enhance the efficacy of ferroptosis‐dependent immunotherapy. Interestingly, the recent advances in bio‐derived material‐based therapeutic platforms offer novel opportunities to therapeutically modulate tumor metabolism through the in situ delivery of molecular or material cues, which not only allows the tumor‐specific elicitation of ferroptosis but also holds promise to maximize their immunostimulatory impact. In this review, we will first dissect the crosstalk between tumor metabolism and ferroptosis and its impact on the immune regulation in the tumor microenvironment, followed by the comprehensive analysis on the recent progress in biomaterial‐based metabolic regulatory strategies for evoking ferroptosis‐mediated antitumor immunity. A perspective section is also provided to discuss the challenges in metabolism‐regulating biomaterials for ferroptosis‐immunotherapy. We envision that this review may provide new insights for improving tumor immunotherapeutic efficacy in the clinic.

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Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders

Salatin,

Farhoudi,

Sadigh-Eteghad

et al. 2024

Expert Opinion on Drug Delivery

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Magnetic Nanoparticle-Driven and Exosome-Mediated Intelligent Targeting Nanovesicles for Inducing Ferroptosis to Surmount Breast Cancer

Cited by 4 publications

References 25 publications

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy

Biomaterial‐Mediated Metabolic Regulation of Ferroptosis for Cancer Immunotherapy

Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders

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