Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering

Poly(Caprolactone)‐Poly(N‐Isopropyl Acrylamide)‐Fe3O4 Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release

“…[ 34 ] Under a higher voltage, the spinning solution can be stretched into thinner fibers owing to a stronger electric field potential acting on the spinning dope. [ 15 ]…”

“…[ 13,14 ] Zhang et al. [ 15 ] fabricated a three‐dimensional composite membrane of poly(ε‐caprolactone)–poly(ethylene glycol)–poly(ε‐caprolactone) containing 10%(w/w) Fe 3 O 4 nanoparticles by co‐spinning technique and confirmed the noncytotoxic nature of the resultant structure. In a study by Kim et al., [ 16 ] co‐polymer of NIPAAm and N ‐hydroxymethylacrylamide (HMAAm) (poly(NIPAAm‐co‐HMAAm)) nanofiber was used to encapsulate DOX and MNPs (Fe 3 O 4 ) and maghemite (γ‐Fe 2 O 3 ) through electrospinning.…”

Synthesis, characterization, and cytotoxicity of PCL–PEG–PCL diacrylate and agarose interpenetrating network hydrogels for cartilage tissue engineering

“…Polyethylene glycol (PEG) is a biocompatible and hydrolytically degradable polymer, therefore, PEG derivatives have been widely used in biomaterials and drug delivery. For example, PEC is one of ester-containing PEG used in tissue engineering, [35] nanotechnology [36,37] and protein/ drug controlled delivery [38,39] since the degradation rates can be controlled by the molecular structure of esters and the degree of branching of the PEGs. [40] Traditional acrylate-derivatized PEG (PEGDA) is a polyether-based hydrogel with endgroup acrylate esters, for that reason, its degradation is due to dydrolysis of the end group acrylate esters and oxidation of the ether backbone.…”

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers

“…As mentioned above, PEO or PEG was electrospun together with PMMA for creation of nanofibers delivering kynurenic acid [95] or with PLGA for delivery of human recombinant EGF and bFGF [90]. Other interesting applications of PEO include creation of electrospun carboxymethylcellulose/PEO nanofibers for delivery of viable commensal bacteria for preventive diabetic foot treatment [101], creation of three-dimensional scaffolds composed of PCL-PEG-PCL tri-block copolymer and iron oxide (Fe 3 O 4 ) nanoparticles for skin tissue engineering [102], creation of biodegradable nanofiber mats based on thermoresponsive multiblock poly(ester urethane)s comprising PEG, poly(propylene glycol) (PPG), and PCL, which showed improved hydrolytic degradation compared to pure PCL and excellent adhesion of human dermal fibroblasts [103]. The adhesion and growth of fibroblast were also improved after combination of PLCL with Pluronic, i.e., a copolymer of PEO and poly(propylene oxide) (PPO) arranged in a tri-block PEO-PPO-PEO structure [104].…”