Magnetic nanoparticles covered with polycyclic aromatic hydrocarbons as singlet oxygen carriers for combining photodynamic therapy and magnetic hyperthermia

Ferreira, I.; Isikawa, Mileni; Nunes, Luiz H.; Micheletto, Mariana C.; Guidelli, Éder José

doi:10.1016/j.jphotochem.2023.114902

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…Additionally, magnetic materials can be coated with various coatings simultaneously, further expanding their versatility and applicability [73]. In the biomedical field, magnetic particles and magnetic composites are utilized as drug carriers [74][75][76][77][78][79][80][81], as contrast agents for magnetic resonance imaging (MRI) [82][83][84][85][86][87], and in magnetic hyperthermia (MH) [26,55,77,80,[88][89][90][91][92][93][94][95][96][97][98], which is also a focus of this short review.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Beković,

Ban,

Drofenik

et al. 2023

Applied Sciences

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This concise review delves into the realm of superparamagnetic nanoparticles, specifically focusing on Fe2O3, Mg1+xFe2−2xTixO4, Ni1−xCux, and CrxNi1−x, along with their synthesis methods and applications in magnetic hyperthermia. Remarkable advancements have been made in controlling the size and shape of these nanoparticles, achieved through various synthesis techniques such as coprecipitation, mechanical milling, microemulsion, and sol–gel synthesis. Through this review, our objective is to present the outcomes of diverse synthesis methods, the surface treatment of superparamagnetic nanoparticles, their magnetic properties, and Curie temperature, and elucidate their impact on heating efficiency when subjected to high-frequency magnetic fields.

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Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Beković,

Ban,

Drofenik

et al. 2023

Applied Sciences

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show abstract

“…For example, combining PDT and chemotherapy reduces the likelihood of tumor recurrence 35 . Other examples of treatments combined with PDT are radiotherapy 40 , ultrasound 41 , and hyperthermia 42 . However, the limited penetration depth of UV-vis light into the human body restricts the scope of photomedicine applications.…”

Section: X-ray As Energy Sourcementioning

confidence: 99%

Activation of photosensitive proteins with radioluminescent nanoparticles and X-rays

Micheletto

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Activation of photosensitive proteins with radioluminescent nanoparticles and XraysPhotodynamic therapy (PDT) is traditionally limited due to the poor penetration of ultravioletvisible (UV-vis) light in human tissues. However, advanced technologies allow the excitation of photosensitizers (PS) at different wavelengths, providing opportunities to discover compatible scintillators. A more efficient complex of nanoparticles and photosensitizers can be designed through a further understanding of the properties of each component of the system. This research focuses on the innovative application of X-rays as an alternative to UV-vis light for deeper tumor excitation in PDT.Scintillating nanoparticles (ScNP) are required as intermediates to convert the energy of X-rays into visible light. The role of PS is fulfilled by genetically encoded proteins. We explore the interaction of the eGFP, KillerOrange, and KillerRed proteins with ScNP LaF3:Tb 3+ in terms of their physicochemical properties and energy transfer, while also investigating the structure, stability, and function of such proteins under adverse physiological conditions and X-ray irradiation. In a second system of project interest, we doped Hafnium Oxide (HfO2) nanoparticles with titanium (Ti) to enhance their luminescence properties and created a stable dispersion in PBS buffer. To stabilize the nanoparticles in PBS, we coated them with citric acid (CA). As the PS in this case, we used the miniSOG protein with its C-terminal modified by the insertion of a glutamate (E) sequence, forming miniSOG-PolyE. The proteins exhibited stability under harsh conditions experienced during cancer therapies. Biophysical characterization of the proteins, combined with tests using ionizing radiation, revealed minimal protein interaction with X-rays. We demonstrated the energy transfer from ScNP to eGFP, KO, and KR. The system consisting of eGFP, KO, and KR conjugated to LaF3:Tb 3+ nanoparticles proved efficient in preventing bacterial culture growth, likely through the generation of reactive oxygen species. The genetic modification that resulted in miniSOG-Poly-E increased the binding with the HfO2 nanoparticle and stabilized the colloidal dispersion in environments similar to biological systems. We propose these systems as promising pathways for the use of genetically encoded photosensitizers in PDT applications with X-rays Further research on this topic could pave the way for more effective cancer therapies and shed light on the interaction of scintillating nanoparticles and proteins to create a conjugated nanocomposite with greater dispersion stability in biological media.

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Magnetic nanoparticles covered with polycyclic aromatic hydrocarbons as singlet oxygen carriers for combining photodynamic therapy and magnetic hyperthermia

Cited by 2 publications

References 56 publications

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Magnetic Nanoparticles as Mediators for Magnetic Hyperthermia Therapy Applications: A Status Review

Activation of photosensitive proteins with radioluminescent nanoparticles and X-rays

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