Magnetic nanoparticles for biomedical applications

Trahms, Lutz

doi:10.1515/bmt-2015-0179

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…[13] The widely used magnetic material is iron oxide composite Fe 3 O 4 , which shows superparamagnetism for a NP diameter less than 20 nm. [14] Magnetic NP (MNP) clusters are frequently utilized, offering an enhanced and cooperative magnetic response that results in improved saturation magnetization and reduced coercive field at low temperatures. [15,16] Despite their size, the functionalization of magnetic surfaces involves lengthy biochemical procedures, posing challenges for scalability in industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Beyond the Passive Diffusion: Core@Satellite Magneto‐Plasmonic Particles for Rapid and Sensitive Colorimetric Immunosensor Response

De Luca,

Acunzo,

Marra

et al. 2024

Advanced Sensor Research

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Magneto‐plasmonic particles, comprising gold and iron oxide, exhibit substantial potential for biosensing applications due to their distinct properties. Gold nanoparticles (AuNPs) provide plasmonic features, while iron oxide composites, responsive to an external magnetic field, significantly reduce detection time compared to passive diffusion. This study explores core@satellite magneto‐plasmonic particles (CSMPs), featuring magnetic nanoparticle clusters and numerous satellite‐like AuNPs, to amplify the optical response on a nanostructured gold surface. Using a sandwich scheme, target analytes are detected as hybrid nanoparticles bind to the pre‐immobilized target on the AuNPs surface, inducing changes in the immunosensor's extinction spectrum. Application of an external magnetic field notably enhances biosensor response and sensitivity, reducing assay time from hours to minutes. Leveraging the properties of CSMPs, the immunosensor detects specific immune protein at low concentrations within minutes. CSMPs hold considerable promise for precise and sensitive analyte detection, offering potential applications in rapid testing and mass screening.

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Section: Introductionmentioning

confidence: 99%

Beyond the Passive Diffusion: Core@Satellite Magneto‐Plasmonic Particles for Rapid and Sensitive Colorimetric Immunosensor Response

De Luca,

Acunzo,

Marra

et al. 2024

Advanced Sensor Research

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“…The decaying field measurements can be used to localize the accumulation of the underlying SPION. SPMR is a highly sensitive technique for the in vivo labeling and detection of tumor cells (at the level of a few thousands cells) by conjugating SPION with antibodies that can bound with specific tumor types (Hathaway et al 2011, Eberbeck et al 2009, Liebl et al 2015, Trahms 2015). For bounded SPION, the decay process is usually long and can last several seconds due to the Neel mechanism (Neel 1955).…”

Section: Introductionmentioning

confidence: 99%

Development of advanced signal processing and source imaging methods for superparamagnetic relaxometry

Huang¹,

Anderson²,

Huang³

et al. 2017

Phys. Med. Biol.

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Superparamagnetic Relaxometry (SPMR) is a highly sensitive technique for the in vivo detection of tumor cells and may improve early stage detection of cancers. SPMR employs superparamagnetic iron oxide nanoparticles (SPION). After a brief magnetizing pulse is used to align the SPION, SPMR measures the time decay of SPION using Super-conducting Quantum Interference Device (SQUID) sensors. Substantial research has been carried out in developing the SQUID hardware and in improving the properties of the SPION. However, little research has been done in the pre-processing of sensor signals and post-processing source modeling in SPMR. In the present study, we illustrate new pre-processing tools that were developed to: 1) remove trials contaminated with artifacts, 2) evaluate and ensure that a single decay process associated with bounded SPION exists in the data, 3) automatically detect and correct flux jumps, and 4) accurately fit the sensor signals with different decay models. Furthermore, we developed an automated approach based on multi-start dipole imaging technique to obtain the locations and magnitudes of multiple magnetic sources, without initial guesses from the users. A regularization process was implemented to solve the ambiguity issue related to the SPMR source variables. A procedure based on reduced chi-square cost-function was introduced to objectively obtain the adequate number of dipoles that describe the data. The new pre-processing tools and multi-start source imaging approach have been successfully evaluated using phantom data. In conclusion, these tools and multi-start source modeling approach substantially enhance the accuracy and sensitivity in detecting and localizing sources from the SPMR signals. Furthermore, multi-start approach with regularization provided robust and accurate solutions for a poor SNR condition similar to the SPMR detection sensitivity in the order of 1000 cells. We believe such algorithms will help establishing the industrial standards for SPMR when applying the technique in pre-clinical and clinical settings.

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Bioavailability assessment of the novel GSH-functionalized FeB nanoparticles via oxidative stress and trace element metabolism in vitro: promising tools for biomedical applications

Aydemir,

Arıbuğa,

Hashemkhani

et al. 2024

J Nanopart Res

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Magnetic nanoparticles for biomedical applications

Cited by 4 publications

References 28 publications

Beyond the Passive Diffusion: Core@Satellite Magneto‐Plasmonic Particles for Rapid and Sensitive Colorimetric Immunosensor Response

Beyond the Passive Diffusion: Core@Satellite Magneto‐Plasmonic Particles for Rapid and Sensitive Colorimetric Immunosensor Response

Development of advanced signal processing and source imaging methods for superparamagnetic relaxometry

Bioavailability assessment of the novel GSH-functionalized FeB nanoparticles via oxidative stress and trace element metabolism in vitro: promising tools for biomedical applications

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