Magnetic nanoparticles hyperthermia in a non-adiabatic and radiating process

Abstract

We investigate the magnetic nanoparticles hyperthermia in a non-adiabatic and radiating process through the calorimetric method. Specifically, we propose a theoretical approach to magnetic hyperthermia from a thermodynamic point of view. To test the robustness of the approach, we perform hyperthermia experiments and analyse the thermal behavior of magnetite and magnesium ferrite magnetic nanoparticles dispersed in water submitted to an alternating magnetic field. From our findings, besides estimating the specific loss power value from a non-adiabatic and radiating process, thus enhancing the accuracy in the determination of this quantity, we provide physical meaning to a parameter found in literature that still remained not fully understood, the effective thermal conductance, and bring to light how it can be obtained from experiment. In addition, we show our approach brings a correction to the estimated experimental results for specific loss power and effective thermal conductance, thus demonstrating the importance of the heat loss rate due to the thermal radiation in magnetic hyperthermia.

In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method

“…The initial rapid temperature rise can be attributed to the loss processes such as hysteresis loss, eddy current loss, Néel relaxation loss, and Brownian relaxation loss. 44 The mechanism of heat generation of magnetic nanoparticles by the alternating magnetic field is different for magnetic nanoparticles having multi-domains and superparamagnetic nanoparticles having single domain configuration. Multi-domain magnetic nanoparticles are heated by hysteresis loss, and superparamagnetic nanoparticles are heated by Néel and Brownian relaxation loss.…”

Therapeutic applications of magnetic nanoparticles: recent advances

“…2 Currently, cellular labelling/ repair, drug delivery, magnetic resonance imaging (MRI), tissue repair, magnetic hyperthermia therapy (MHT), photodynamic therapy (PDT), photothermal therapy (PTT) and magnetofection for gene delivery are some of the prominent examples of biomedical applications shown by MNPs. [3][4][5][6][7][8][9][10][11][12] Such a variety of biomedical applications demands a narrow size distribution, a high surface-to-volume ratio, high biocompatibility, low toxicity, a high magnetic moment and the high magnetization of nanoparticles. 13,14 Among the different MNPs, iron oxide nanoparticles (IONPs) have been the most widely studied nanomaterials for decades since they are safe, biocompatible, and have significant clinical utility.…”

A novel magnetophoretic-based device for magnetometry and separation of single magnetic particles and magnetized cells

“…Magnetic particles, ranging from nanometers to micrometers in size, due to their unique magnetic properties and surface-to-volume ratio, have great potential in the fields of biology, immunology, and medicine. In particular, these particles are widely used in various bio-applications such as targeted drug delivery, 1–3 sorting and separation, 4–8 bio-detection, 9,10 single-cell analysis, 11–14 magnetic hyperthermia, 15–18 and medical imaging. 19,20 In these applications, magnetic particles respond to an externally applied magnetic field in highly complex matrices in biological environments, enabling highly selective manipulation, separation, and detection.…”