Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging

Jain, Tapan K.; Richey, J.; Strand, Michelle A.; Leslie‐Pelecky, Diandra L.; Flask, Chris A.; Labhasetwar, Vinod

doi:10.1016/j.biomaterials.2008.07.004

Cited by 438 publications

(291 citation statements)

References 45 publications

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“…microglia, astrocytes (the major homeostatic regulators of the CNS), oligodendrocyte precursor cells (OPCs; which generate oligodendrocytes and ultimately myelin, the insulating sheath around nerve fibres), neurons (the transmitters of electrical signals) and neural stem cells (NSCs; the major stem/precursor cells of the CNS). MNPs were selected for these experiments as they offer combined capacity for biomolecule delivery and nanoparticle imaging in sites of pathology for neurological applications [24,25]. The specific study aims were to: (i) assess if PEGylation reduces particle clearance by microglial cells; (ii) conduct a pan-cellular assessment of uptake of PEGylated nanoparticles in the major brain cell types; (iii) identify protein corona features that may contribute to differing particle uptake profiles.…”

Section: Figure 1 Schematic Diagram Illustrating the Major Barriers mentioning

confidence: 99%

‘Stealth’ nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

Jenkins

Weinberg

al-Shakli

et al. 2016

Journal of Controlled Release

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Section: Figure 1 Schematic Diagram Illustrating the Major Barriers mentioning

confidence: 99%

‘Stealth’ nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

Jenkins

Weinberg

al-Shakli

et al. 2016

Journal of Controlled Release

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“…Relaxation rates R 1 (1/T 1 ) and R 2 (1/T 2 ) were calculated by mono-exponential curve fitting of the signal intensity vs. time (TE or TR). The Equations (1) and (2) were used for curve fitting of relaxation rate R 1 and R 2 , respectively [33]: For relaxation rate R 1 :…”

Section: Characterization Techniquesmentioning

confidence: 99%

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Arsalani¹,

Fattahi²,

Nazarpoor³

2010

Express Polym. Lett.

236

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Abstract. The magnetite (Fe3O4) nanoparticles (MNPs) coated with poly(N-vinyl pyrrolidone) (PVP) via covalent bonds were prepared as T2 contrast agent for magnetic resonance imaging (MRI). The surface of MNPs was first coated with 3-(trimethoxysilyl) propyl methacrylate (silan A) by a silanization reaction to introduce reactive vinyl groups onto the surface, then poly(N-vinyl pyrrolidone) was grafted onto the surface of modified-MNPs via surface-initiated radical polymerization. The obtained nanoparticles were characterized by FT-IR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction), TEM (transmission electron microscopy), VSM (vibrating sample magnetometer), and TGA (thermogravimetric analysis). The MNPs had an average size of 14 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. T2-weighted MRI images of PVP-grafted MNPs showed that the magnetic resonance signal is enhanced significantly with increasing nanoparticle concentration in water. The r1 and r2 values per millimole Fe, and r2/r1 value of the PVP-grafted MNPs were calculated to be 2.6 , 72.1, and 28.1(mmol/l) -1 ·s -1 , respectively. These results indicate that the PVP-grafted MNPs have great potential for application in MRI as a T2 contrast agent. Vol.4, No.6 (2010) 329-338 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2010.42 region that they are accumulated, and hence cause negative contrast and provide a dark state in the image where the compounds are accumulated [15]. However, the direct use of magnetic nanoparticles as in vivo MRI contrast agent results in biofouling of the particles in blood plasma and formation of aggregates that are quickly sequestered by cells of the reticular endothelial system (RES) such as macrophages [16,17]. Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24]. While there is a potential concern about covalent interaction between hydrophilic polymers and magnetic nanoparticles in order to increase their stability in physiological medium [25][26][27][28][29], PVP coating on Fe 3 O 4 nanoparticles in all previous works has been achieved through noncovalent interaction. Now, polymers grafting of magnetic nanoparticles is one of the most attractive methods of surface modification [30,31]. In the present study, we carried out chemical synthesis and characterization of PVP-functionalized magnetite (Fe 3 O 4 ) nanoparticles. Since the PVP was bonded to the surface of magnetite nanoparticles through covalent bonds, the prepared magnetic fluid (ferrofluid) was ve...

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“…Iron is of interest as a substituted cation in HA due to the fact it is present naturally in trace amounts in both teeth and bone [8]. Additionally, its presence provides iron substituted apatite (FeHA) with possible magnetic properties that can potentially be applied to varied applications, including drug delivery, medical imaging, or hyperthermia based cancer therapies, for which pure HA is unsuitable [9,[14][15][16][17][18]. The use of magnetic materials in these biomedical applications has the potential to greatly improve the prognosis for numerous patients suffering from a wide variety of diseases, but currently the most widely used magnetic nanoparticles for biomedical applications remain iron oxides.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

Kramer¹,

Zilm²,

Wei³

2013

Bioceram Dev Appl

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Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA lends itself to a wide variety of substitutions, which allows for tailoring of material properties. Iron is of interest in ion substitution in HA due to its magnetic properties. The synthesis and characterization of iron-substituted hydroxyapatite (FeHA) have been widely studied, but there is a lack of studies on the sintering behaviors of FeHA materials compared to pure HA. Studying the sintering behavior of a substituted apatite provides information regarding how the substitution affects material characteristics such as stability and bulk mechanical properties, thereby providing insight into which applications are appropriate for the substituted material. In this study both pure HA and FeHA were synthesized, pressed into pellets, and then sintered at temperatures ranging from 900-1300°C and 600-1100°C, respectively. The study thoroughly examined the comparative sintering behaviors of the two materials using density measurements, mechanical testing, X-ray diffraction, and electron microscopy. It was found that FeHA is considerably less thermally stable than pure HA, with decomposition beginning around 1200°C for pure HA samples, while at 700°C for the FeHA. The FeHA also had a much lower mechanical strength than that of the pure HA. An in vitro cell culture study was conducted by immersing FeHA powder in cell culture media, with HA powder at equivalent doses as a control, verified that FeHA is a biocompatible material. Although the FeHA would be unsuitable for bulk applications, it is a potential material for a variety of biomedical applications including drug delivery, cancer hyperthermia, and bone tissue engineering composites.

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Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging

Cited by 438 publications

References 45 publications

‘Stealth’ nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

‘Stealth’ nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite

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