Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement

Rarokar, Nilesh; Yadav, Sakshi; Saoji, Suprit; Bramhe, Pratiksha; Agade, Rishabh; Gurav, Shailendra; Khedekar, Pramod; Subramaniyan, Vetriselvan; Wong, Ling Shing; Kumarasamy, Vinoth

doi:10.1016/j.ijpx.2024.100231

Cited by 10 publications

(3 citation statements)

References 193 publications

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“…Developed by Stephanie Huth and coworkers [ 125 ] magnetofection was first used for MNP–naked DNA complexes or MNP–viral vector complexes that were attracted to the bottom by a magnet, placed close below the bottom of a dish. Subsequently, nucleic acid-bound MNPs could be introduced into the cells after their exposition to AMF [ 126 ].…”

Section: Combination Therapies Using Np-based Mhtmentioning

confidence: 99%

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

Szwed,

Marczak

2024

Cancers

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Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39–45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death. In addition, the recent development of nanocarriers as NP-based drug delivery systems is discussed. Finally, the efficacy of HT combined with chemotherapy, radiotherapy, gene therapy, photothermal therapy, and immunotherapy is explored.

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Section: Combination Therapies Using Np-based Mhtmentioning

confidence: 99%

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

Szwed,

Marczak

2024

Cancers

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“…The most commonly synthesized magnetic nanoparticles for biomedical applications are iron oxide nanoparticles (IONPs) consisting of magnetite (Fe 3 O 4 ), maghemite (γ-Fe 2 O 3 ), hematite (α-Fe 2 O 3 ), or mixed ferrites [ 144 ]. The popularity of IONPs as drug carriers comes from their biocompatibility, non-toxicity, ease of preparation, and stability [ 145 , 146 , 147 ].…”

Section: Magnetic Nanoparticles As a Platform For Tumor-homing Peptidesmentioning

confidence: 99%

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Milewska,

Sadowska,

Stefaniuk

et al. 2024

IJMS

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According to data from the World Health Organization (WHO), cancer is considered to be one of the leading causes of death worldwide, and new therapeutic approaches, especially improved novel cancer treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend to have poor pharmacokinetic profiles, including rapid clearance and limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead to remarkable improvements. This is confirmed by an increasing number of papers in this field, showing that the on-target peptide functionalization of magnetic nanoparticles improves their penetration properties and ensures tumor-specific binding, which results in an increased clinical response. This review aims to highlight the potential applications of THPs in combination with magnetic carriers across various fields, including a pharmacoeconomic perspective.

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“…When synchronized with an external magnetic field and magnetizable implants, magnetic nanosystems enhance the precision of particle delivery to specific areas and exert localized effects. 55 Subsequently, the plasma stability and distribution of the nanosystem in different organs after systemic administration in the presence or absence of magnetic field were investigated utilizing ICP-MS. As shown in Figure 6a, the blood circulation of IONPs was significantly prolonged by NV-IONP-Lapa owing to the coupling of more biocompatible NVs, resulting in slightly greater accumulation in tumor tissues (P > 0.05), probably through the homing effect of NVs originating from normal ovarian epithelial cells and the enhanced permeability and retention (EPR) effect. 56 However, this prolonged blood circulation was attenuated by application of a magnet due to magnetic field-guided rebiodistribution of drugs (Figure 6a), resulting in significantly boosted (approximately 10-fold enhanced) accumulation of NV-IONP-Lapa in tumor site as indicated by fluorescence imaging (Figures 6b and S26).…”

Section: Efficient Tumor Cells Killing Of Nv-ionp-lapa In Vitromentioning

confidence: 99%

Engineering Magnetic Extracellular Vesicles Mimetics for Enhanced Targeting Chemodynamic Therapy to Overcome Ovary Cancer

Wang,

Mao,

Rong

et al. 2024

ACS Appl. Mater. Interfaces

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Chemodynamic therapy (CDT), employing metal ions to transform endogenous H 2 O 2 into lethal hydroxyl radicals ( • OH), has emerged as an effective approach for tumor treatment. Yet, its efficacy is diminished by glutathione (GSH), commonly overexpressed in tumors. Herein, a breakthrough strategy involving extracellular vesicle (EV) mimetic nanovesicles (NVs) encapsulating iron oxide nanoparticles (IONPs) and β-Lapachone (Lapa) was developed to amplify intracellular oxidative stress. The combination, NV-IONP-Lapa, created through a serial extrusion from ovarian epithelial cells showed excellent biocompatibility and leveraged magnetic guidance to enhance endocytosis in ovarian cancer cells, resulting in selective H 2 O 2 generation through Lapa catalysis by NADPH quinone oxidoreductase 1 (NQO1). Meanwhile, the iron released from IONPs ionization under acidic conditions triggered the conversion of H 2 O 2 into • OH by the Fenton reaction. Additionally, the catalysis process of Lapa eliminated GSH in tumor, further amplifying oxidative stress. The designed NV-IONP-Lapa demonstrated exceptional tumor targeting, facilitating MR imaging, and enhanced tumor suppression without significant side effects. This study presents a promising NV-based drug delivery system for exploiting CDT against NQO1-overexpressing tumors by augmenting intratumoral oxidative stress.

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Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement

Cited by 10 publications

References 193 publications

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective

Engineering Magnetic Extracellular Vesicles Mimetics for Enhanced Targeting Chemodynamic Therapy to Overcome Ovary Cancer

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