Magnetic nanovectors for drug delivery

Klostergaard, Jim; Seeney, Charles E.

doi:10.1016/j.nano.2012.05.010

Cited by 64 publications

(41 citation statements)

References 100 publications

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“…Although considerable success has already been achieved (e.g., Herceptin ® ), the limits of this strategy have become clear. The targeted blockage of a specific signaling pathway has led to the emergence of genetically mutated cancer cells that are able to circumvent this blockage by upregulation of an effective parallel, alternative, or overlapping pathway [13] . That leads to broad-spectrum medicinal products being used again.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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Abstract:Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use of magnetic nanoparticles consisting of the elements nickel, cobalt, and iron can make a significant contribution. The greatest potential can be ascribed to the drug delivery systems: magnetic nanoparticles are functionalized by binding them to various substances, including chemotherapeutic agents, radionuclides, nucleic acids, and antibodies. They can then be guided and accumulated using a magnetic field. Hyperthermia can be induced with an alternating magnetic field, providing another therapeutic option. Magnetic nanoparticles may be useful in overcoming cancer drug resistance. They also contribute to realizing a combination of diagnostic investigation and therapy in the field of " theranostics " . The multifaceted and promising results of research in the recent years offer the prospect of a real advance in cancer therapy in the near future.

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Section: Introductionmentioning

confidence: 99%

“…Mostly, they are used as hybrids with other metal ions, oxygen, or carbon dioxide. There are innumerable possibilities for such combinations [13] . The iron compounds are predominantly used because of their biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles for cancer therapy

Dürr

Janko

Lyer

et al. 2013

Nanotechnology Reviews

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“…Developed magnetic chitosan microspheres In most cases, Chitosan has been selected as a polymeric shell on the magnetic nanoparticles, responsible for the temperature, pH, and magnetic changes during targeted drug delivery [11,71]. Klostergaard and Seeney applied SPIONs which were modified with o-carboxymethyl chitosan (OCMCS) and folic acid (FA) to attempt to improve their biocompatibility and ability to target specific tumor cells, simultaneously evading the RES [96].…”

Section: Magneto-responsive Chitosan Nanocarriersmentioning

confidence: 99%

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

et al. 2014

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Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand-receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.

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“…92 Nanovectors based on the three ferromagnetic elements Co, Ni, and Fe can be used either to mediate a hyperthermic effect (predominantly causing tumor necrosis) or to deliver drugs to achieve intratumoral levels. Nickel-based nanomaterials have also been reported for tumor targeting by serving either as inducers of hyperthermia in response to an externally applied magnetic field (as drug-delivery platforms) 93 or directly as proapoptotic mediators.…”

Section: Magnetic Nanovectors For Drug Deliverymentioning

confidence: 99%

Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

149

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Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

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Magnetic nanovectors for drug delivery

Cited by 64 publications

References 100 publications

Magnetic nanoparticles for cancer therapy

Magnetic nanoparticles for cancer therapy

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

Nanotechnology-based approaches in anticancer research

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