Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay, Zhi Wei; Chandrasekharan, Prashant; Fellows, Benjamin D.; Rodrigo, Irati; Yu, Elaine; Olivo, Malini; Conolly, Steven M.

doi:10.3390/cancers13215285

Cited by 39 publications

(18 citation statements)

References 158 publications

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“…[82] MPI directly detects the iron oxide particle tracers and constructs 3D structures with exceptional contrast and temporal resolution. [83] The spatial resolution of MPI is at a millimeter scale. By increasing the intensity of the magnetic field gradient or fabricating the microrobot using paramagnetic materials with higher susceptibility, the spatial resolution will be improved.…”

Section: Mri and Mpimentioning

confidence: 99%

Control and Autonomy of Microrobots: Recent Progress and Perspective

Jiang

Yang

Ferreira

et al. 2022

Advanced Intelligent Systems

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After decades of development, microrobots have exhibited great application potential in the biomedical field, such as minimally invasive surgery, drug delivery, and bio‐sensing. Compared with conventional medical robotic systems, microrobots may be capable of reaching more narrow and vulnerable regions in the human body with minimal damage. However, limited by the small scale of microrobots, microprocessors, power supplies, and sensors can hardly be integrated on‐board. Thus, new strategies for the actuation and feedback for microrobots need to be explored. Furthermore, the open‐loop control method accomplished by operators may lack accuracy, and long‐duration operation could bring a severe physical challenge in many applications. Consequently, the automatic control of microrobots with the aid of control theories is developed to improve the control efficiency and precision. To further promote the automation level of microrobots, machine learning algorithms are expected to provide a solution to let microrobots adapt to more dynamic environments and undertake more complex medical tasks. Herein, a systematic introduction of the manipulation of microrobots from open‐loop to closed‐loop control is given in this review. It is envisioned that microrobots will play an important role in future biomedical applications.

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Section: Mri and Mpimentioning

confidence: 99%

Control and Autonomy of Microrobots: Recent Progress and Perspective

Jiang

Yang

Ferreira

et al. 2022

Advanced Intelligent Systems

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“…X-space reconstruction is performed without a precalibration step through velocity compensation and gridding the received instantaneous signal to the known FFP locations in three-dimensional (3D) space. The FFP commonly passes through the FOV on a Cartesian trajectory or Lissajous trajectory (Tay et al, 2021a).…”

Section: Imaging Modalitymentioning

confidence: 99%

“…They then observed that tumors almost disappeared (Du et al, 2019). The anisotropy and colloidal stability of particles also lead to the higher SAR of the new particle relative to feridex (Khurshid et al, 2015;Bauer et al, 2016;Reichel et al, 2020;Tay et al, 2021a).…”

Section: Combination With Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Applications of Magnetic Particle Imaging in Biomedicine: Advancements and Prospects

et al. 2022

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Magnetic particle imaging (MPI) is a novel emerging noninvasive and radiation-free imaging modality that can quantify superparamagnetic iron oxide nanoparticles tracers. The zero endogenous tissue background signal and short image scanning times ensure high spatial and temporal resolution of MPI. In the context of precision medicine, the advantages of MPI provide a new strategy for the integration of the diagnosis and treatment of diseases. In this review, after a brief explanation of the simplified theory and imaging system, we focus on recent advances in the biomedical application of MPI, including vascular structure and perfusion imaging, cancer imaging, the MPI guidance of magnetic fluid hyperthermia, the visual monitoring of cell and drug treatments, and intraoperative navigation. We finally optimize MPI in terms of the system and tracers, and present future potential biomedical applications of MPI.

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“…Fifty years later, in 2010, MagForce AG company (Berlin, Germany) obtained European Union Regulatory Approval (10/2011) for its the Nanotherm ® therapy and later in 2013 started a clinical study in current glioblastoma with Nanotherm ® therapy at the Charité Hospital in Berlin. Recently, the FDA approved the Nanotherm ® therapy system for intermediate-risk prostate cancer [12,13].…”

Section: Introductionmentioning

confidence: 99%

Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy

Parte

Rodrigo

Gutiérrez-Basoa

et al. 2022

Cancers

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Background: Lately, major advances in crucial aspects of magnetic hyperthermia (MH) therapy have been made (nanoparticle synthesis, biosafety, etc.). However, there is one key point still lacking improvement: the magnetic field-frequency product (H × f = 4.85 × 108 Am−1s−1) proposed by Atkinson–Brezovich as a limit for MH therapies. Herein, we analyze both local and systemic physiological effects of overpassing this limit. Methods: Different combinations of field frequency and intensity exceeding the Atkinson–Brezovich limit (591–920 kHz, and 10.3–18 kA/m) have been applied for 21 min to WAG/RijHsd male rats, randomly distributed to groups of 12 animals; half of them were sacrificed after 12 h, and the others 10 days later. Biochemical serum analyses were performed to assess the general, hepatic, renal and/or pancreatic function. Results: MH raised liver temperature to 42.8 ± 0.4 °C. Although in five of the groups the exposure was relatively well tolerated, in the two of highest frequency (928 kHz) and intensity (18 kA/m), more than 50% of the animals died. A striking elevation in liver and systemic markers was observed after 12 h in the surviving animals, independently of the frequency and intensity used. Ten days later, liver markers were almost recovered in all of the animals. However, in those groups exposed to 591 kHz and 16 kA/m, and 700 kHz and 13.7 kA/m systemic markers remained altered. Conclusions: Exceeding the Atkinson–Brezovich limit up to 9.59 × 109 Am−1s−1 seems to be safe, though further research is needed to understand the impact of intensity and/or frequency on physiological conditions following MH.

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Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Cited by 39 publications

References 158 publications

Control and Autonomy of Microrobots: Recent Progress and Perspective

Control and Autonomy of Microrobots: Recent Progress and Perspective

Applications of Magnetic Particle Imaging in Biomedicine: Advancements and Prospects

Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy

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