Magnetic particle imaging for assessment of cerebral perfusion and ischemia

Abstract

Stroke is one of the leading worldwide causes of death and sustained disability. Rapid and accurate assessment of cerebral perfusion is essential to diagnose and successfully treat stroke patients. Magnetic particle imaging (MPI) is a new technology with the potential to overcome some limitations of established imaging modalities. It is an innovative and radiation-free imaging technique with high sensitivity, specificity, and superior temporal resolution. MPI enables imaging and diagnosis of stroke and other neurological pathologies such as hemorrhage, tumors, and inflammatory processes. MPI scanners also offer the potential for targeted therapies of these diseases. Due to lower field requirements, MPI scanners can be designed as resistive magnets and employed as mobile devices for bedside imaging. With these advantages, MPI could accelerate and improve the diagnosis and treatment of neurological disorders. This review provides a basic introduction to MPI, discusses its current use for stroke imaging, and addresses future applications, including the potential for clinical implementation.

Complementary early-phase magnetic particle imaging and late-phase positron emission tomography reporter imaging of mesenchymal stem cells in vivo

“…MPI is a relatively novel imaging modality developed in the early 2000s capable of directly detecting the magnetization of iron-oxide probes with the use of low-frequency magnetic fields. 48 Both prototype and commercial MPI scanners have been used in several studies for vascular imaging, 49 oncology 50,51 and cell tracking applications. 4,52 MPI holds promise for clinical integration for cell-tracking applications as it has high depth penetration, produces linear quantification, provides hyperintense “hot-spot” contrast with nearly no background signal from tissues, and can achieve high sensitivity.…”

“…MPI is a relatively novel imaging modality developed in the early 2000s capable of directly detecting the magnetization of iron-oxide probes with the use of low-frequency magnetic fields. 48 Both prototype and commercial MPI scanners have been used in several studies for vascular imaging, 49 Fig. 4 MPI (A) and BLI (B) signal from early imaging timepoints (days 0-9 post MSC injection), and correlational analysis of this data (C).…”

SPIONs Conjugate Supported Anticancer Drug Doxorubicin’s Delivery: Current Status, Challenges, and Prospects

“…For both MRI and MPI, Resovist ® has been used as SPIONs-based contrast agent. A current and comprehensive review on MNPs applications [ 124 ] and scanner developments [ 125 ] is available for more details.…”

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

“…11 Consistently, ROS-targeting therapies have exhibited great promise in preclinical studies, yet traditional antioxidants such as vitamin C, vitamin E, and Nacetylcysteine have failed to achieve clear efficacy in a clinical context, 12−14 with no antioxidant drugs being routinely used in clinical practice at present. In recent years, huge progress has been made in nanomaterials applied in almost all areas of medicine for therapeutic and diagnosis purposes, such as tumor, 15,16 ischemic stroke, 17,18 infectious disease, 19,20 autoimmune disease, 21,22 and impaired wound healing. 23 Nanozymes are small, enzymelike nanomaterials that exhibit many clinical advantages owing to their excellent stability, high levels of activity, good scalability, low costs, and ready applicability to use in caustic environments.…”

“…In recent years, huge progress has been made in nanomaterials applied in almost all areas of medicine for therapeutic and diagnosis purposes, such as tumor, , ischemic stroke, , infectious disease, , autoimmune disease, , and impaired wound healing . Nanozymes are small, enzyme-like nanomaterials that exhibit many clinical advantages owing to their excellent stability, high levels of activity, good scalability, low costs, and ready applicability to use in caustic environments .…”