Magnetic Particle Imaging

Zheng, Bo; Lu, Kuan; Konkle, Justin; Hensley, Daniel; Keselman, Paul; Orendorff, Ryan; Tay, Zhi Wei; Yu, Elaine; Bishop, Mindy; Gunel, Beliz; Taylor, Laura A.; Ferguson, R. Matthew; Khandhar, Amit P.; Kemp, Scott J.; Krishnan, Kannan M.; Goodwill, Patrick; Conolly, Steven M.

doi:10.1007/978-3-319-42169-8_4

Cited by 8 publications

(3 citation statements)

References 75 publications

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“…MPI is a tracer-based modality that directly images superparamagnetic iron oxide nanoparticles (SPIONs), [23] with signal intensity and resolution critically dependent on their in vivo relaxation dynamics. [24] As such, MPI offers high image contrast (with negligible background signal from diamagnetic tissue), a signal linear with tracer concentration [25] and zero depth attenuation, and is safe as it uses no ionizing radiation, as compared with many other biomedical imaging methods. Additionally, a demonstrated high sensitivity (200 nm Fe) [26] and high temporal resolution [27] is achieved when optimized SPIONs of tailored size and size dispersity are used [28,29].…”

Section: Introductionmentioning

confidence: 99%

Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging

2019

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Section: Introductionmentioning

confidence: 99%

Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging

2019

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“…MPI applies a magnetic gradient field with a central field-free point to the imaging FOV; this field saturates the nonlinear magnetization of magnetic particles . Electromagnets scan the field-free point to form an image, and the MPI signal is generated when the field-free point passes an area with magnetic particles .…”

Section: Introductionmentioning

confidence: 99%

Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells

Lemaster

Chen

Kim

et al. 2018

ACS Appl. Nano Mater.

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Stem cell therapy has the potential to improve tissue remodeling and repair. For cardiac stem cell therapy, methods to improve the injection and tracking of stem cells may help to increase patient outcomes. Here we describe a multimodal approach that combines ultrasound imaging, photoacoustic imaging, and magnetic particle imaging (MPI). Ultrasound imaging offers real-time guidance, photoacoustic imaging offers enhanced contrast, and MPI offers high-contrast, deep-tissue imaging. This work was facilitated by a poly(lactic-co-glycolic acid) (PLGA)-based iron oxide nanobubble labeled with 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) as a trimodal contrast agent. The PLGA coating facilitated the ultrasound signal, the DiR increased the photoacoustic signal, and the iron oxide facilitated the MPI signal. We confirmed that cell metabolism, proliferation, differentiation, and migration were not adversely affected by cell treatment with nanobubbles. The nanobubble-labeled cells were injected intramyocardially into live mice for real-time imaging. Ultrasound imaging showed a 3.8-fold increase in the imaging intensity of labeled cells postinjection compared to the baseline; photoacoustic imaging showed a 10.2-fold increase in the cardiac tissue signal postinjection. The MPI intensity of the nanobubble-treated human mesenchymal stem cells injected into the hearts of mice was approximately 20-fold greater than the negative control.

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“…10–15 However, efforts to improve MPI scanners/spectrometers and design of functionalized contrast agents are still required to not only enhance MPI performance such as spatial resolution, signal intensity and imaging speed, but also to develop promising translational medical applications. 16 …”

Section: Introductionmentioning

confidence: 99%

Tomographic magnetic particle imaging of cancer targeted nanoparticles

et al. 2017

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Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a biofunctionalized shell. Successful application of MPI to imaging of cancer depends on the nanoparticles (NPs) accumulating at tumors at sufficient levels relative to other sites. NPs physiochemical properties such as size, crystallographic structure and uniformity, surface coating, stability, blood circulation time and magnetization determine the efficacy of their tumor accumulation and MPI signal generation. Here, we address these criteria by presenting strategies for the synthesis and surface functionalization of efficient MPI tracers, that can target a typical murine brain cancer model and generate three dimensional images of these tumors with very high signal-to-noise ratios (SNR). Our results showed high contrast agent sensitivities that enabled us to detect 1.1ng of iron (SNR~3.9) and enhance the spatial resolution to about 600μm. The biodistribution of these NPs was also studied using near infra-red fluorescent (NIRF) and single-photon emission computed tomography (SPECT) imaging. NPs were mainly accumulated in liver and spleen and did not show any renal clearance. This first pre-clinical study of cancer targeted NPs imaged using a tomographic MPI system in an animal model, paves the way to explore new nanomedicine strategies for cancer diagnosis and therapy, using clinically safe magnetic iron oxide nanoparticles and MPI.

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Magnetic Particle Imaging

Cited by 8 publications

References 75 publications

Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging

Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging

Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells

Tomographic magnetic particle imaging of cancer targeted nanoparticles

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