Magnetic porous carbon nanocomposites derived from metal-organic frameworks as a sensing platform for DNA fluorescent detection

Tan, Hongliang; Tang, Gonge; Wang, Zhixiong; Li, Qian; Gao, Jie; Wu, Shunchuan

doi:10.1016/j.aca.2016.08.024

Cited by 57 publications

(18 citation statements)

References 50 publications

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“…Besides, MOF-derived porous carbon has been extensively developed in biosensing, especially in electrochemical sensing owing to their outstanding merits (such as excellent stability, conductivity reproducibility, repeatability, etc.). It has been proved to be an outstanding fluorophore quencher for virus detection with low background signal ( Tan et al, 2016 ). Using ZIF-8 as a precursor, Li et al, (2019b) prepared nitrogen-doped MOFs-derived porous carbons with the advantages of chemical stability, low-cost, and good conductivity for the ﬂuorescence detection of Zika virus RNA sequences.…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…For instance, due to their abilities for selective absorbing single‐stranded DNA (ssDNA) and quenching the labeled fluorescent dye, carbon materials were claimed to be sensing platforms for DNA detection . A magnetic porous carbon (MPC) nanocomposite produced by a one‐pot thermolysis of iron‐containing MOFs (MIL‐88A) was reported recently to behave well in forming double‐stranded DNA with target DNA and in releasing ssDNA probes from the MPC surface . The composite exhibited high sensitivities with a detection limit of 1 × 10 −9 m and excellent selectivity to specific target DNA.…”

Section: Othersmentioning

confidence: 99%

Applications of Metal–Organic‐Framework‐Derived Carbon Materials

et al. 2018

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production, especially for hydroelectricity, sunlight, and wind energy, which cannot be gathered or released when they are needed. [5][6][7][8] Electrochemical energy storage devices provide a promising approach for the storage of electric energy from these sources. [9][10][11] Currently, carbonaceous materials have attracted much interest for their extensive applications including adsorption, [12] catalysis, [13] batteries, [14] fuel cells, [15,16] supercapacitors, [17,18] and drug delivery and imaging. [19] In addition, some sensors are also one of the important applications of carbonaceous materials, because they are closely related to human health. [20,21] For instance, Emran and co-workers [22] constructed ultrasensitive biosensors with N-doped mesoporous carbon (NMC)-based electrodes for in vitro monitoring of DA released from living cells. With the further study of the experiment, they also designed a series of S-doped carbon materials for a wider detection of DA, UA (uric acid), and AA (ascorbic acid). [23,24] The advantages of easy preparing, nontoxic and excellent electrical conductivity of carbonaceous materials, which are rare among energy storage materials, make carbonaceous materials superior to most of the energy storage materials. [25][26][27] There are varieties of approaches for the preparation of carbon materials, such as directly carbonizing from organic precursors, physically or chemically carbonizing from carbon, template methods using zeolites and mesoporous silica, solvothermal and hydrothermal methods with elevated temperature, the electrical arc methods, and chemical vapor decomposition (CVD) methods. [28][29][30][31][32][33][34] Among all these approaches, directly carbonizing from organic precursors is the most frequently used method to prepare nanoporous carbons (NPCs) due to its flexibility and simplicity. [35][36][37] However, these NPC materials present certain drawbacks, such as low surface areas, disordered structures, and ununiformed sizes, which will greatly limit their applications. [25] As studies have progressed, researchers found that carbon materials derived from metalorganic frameworks (MOFs) could overcome these limitations.Metal-organic frameworks, which are also named porous coordination polymers (PCPs), are crystalline porous materials with periodic network structures formed by metal ions (or metal clusters) and organic ligands. [38][39][40][41][42] They are usually prepared by solvothermal methods and used as precursors or templates to form nanostructured materials. [43][44][45] So far, many researchers have highlighted the advantages of MOFs. For Carbon materials derived from metal-organic frameworks (MOFs) have attracted much attention in the field of scientific research in recent years because of their advantages of excellent electron conductivity, high porosity, and diverse applications. Tremendous efforts are devoted to improving their chemical and physical properties, including optimizing the morphology and structure of the carbon materials, compositing them wi...

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“…Recently, MOFs have been used as a fluorescent detection sensor for DNA and proteins [ 94 ]. Tan et al used iron-containing MOFs (MIL-88A; MIL: Materials Institute Lavoisier) as precursors via the one-pot thermolysis method to synthesize a porous carbon-coated magnetic Fe 3 O 4 NP nanocomposite and investigated its application to fluorescent sensing for DNA detection [ 95 ].…”

Section: Functionalization Of Fe 3 O mentioning

confidence: 99%

Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems

2018

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Fe3O4 nanoparticles (NPs), the most traditional magnetic nanoparticles, have received a great deal of attention in the biomedical field, especially for targeted drug/gene delivery systems, due to their outstanding magnetism, biocompatibility, lower toxicity, biodegradability, and other features. Naked Fe3O4 NPs are easy to aggregate and oxidize, and thus are often made with various coatings to realize superior properties for targeted drug/gene delivery. In this review, we first list the three commonly utilized synthesis methods of Fe3O4 NPs, and their advantages and disadvantages. In the second part, we describe coating materials that exhibit noticeable features that allow functionalization of Fe3O4 NPs and summarize their methods of drug targeting/gene delivery. Then our efforts will be devoted to the research status and progress of several different functionalized Fe3O4 NP delivery systems loaded with chemotherapeutic agents, and we present targeted gene transitive carriers in detail. In the following section, we illuminate the most effective treatment systems of the combined drug and gene therapy. Finally, we propose opportunities and challenges of the clinical transformation of Fe3O4 NPs targeting drug/gene delivery systems.

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Magnetic porous carbon nanocomposites derived from metal-organic frameworks as a sensing platform for DNA fluorescent detection

Cited by 57 publications

References 50 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Applications of Metal–Organic‐Framework‐Derived Carbon Materials

Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems

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