Magnetic properties of nanostructured hollow microspheres

Gruner, Markus E.; Entel, P.

doi:10.1016/j.jmmm.2006.10.917

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…For example, magnetic resonance imaging (MRI) contrasts agents [15] . The success of these technologies depends largely on the synthesis of magnetic spheres from biocompatible, non-toxic polymers such as Methyl methacrylate (Eudragit L-100) and ethyl cellulose [16][17][18][19] . For applications requiring invivo magnetic targeting, for example, magnetic drug delivery, the magnetic carriers must have a proper size range (i.e.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Methyl Methacrylate Microspheres Loaded with Indomethacin by Emulsion Solvent Evaporation Technique.

Varma¹,

Amareshwar²,

Devara³

2011

Int J Drug Del

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Magnetic nanoparticles encapsulated in Methyl methacrylate (Eudragit L-100) microspheres containing Indomethacin drug were prepared and their detailed structural and magnetic characteristics were studied. Iron oxide nanoparticles were obtained by chemical coprecipitation of Fe(II) and Fe(III) salts and stabilized with tetra-methyl ammonium hydroxide. Microspheres were prepared by solvent evaporation technique. We characterized the magnetic microspheres in terms of morphology, composite microstructure, size and size distribution, magnetic properties and in-vitro release patterns. The microspheres were uniform both in shape and usually also in size; their size distribution was narrow. All the magnetic parameters confirm superparamagnetic nature of the microspheres with magnetizations up to 20-30 emu/g of microspheres. The in-vitro release profile was studied in pH 7.4 phosphate buffer medium up to 8 hours using USP XXII dissolution apparatus. Drug release in the first hour was found to increase and reached a maximum, releasing approximately 60-85% of the total drug content from the microspheres within 8 hours. From this study, it could be suggested that magnetic Methyl methacrylate microspheres could be retained at their target site invivo and such microspheres can be used in biomedical applications and research areas such as target drug delivery, selective blood detoxification, tissue engineering and replacement, and magnetic resonance imaging (MRI) contrast agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Methyl Methacrylate Microspheres Loaded with Indomethacin by Emulsion Solvent Evaporation Technique.

Varma¹,

Amareshwar²,

Devara³

2011

Int J Drug Del

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“…Due to their special properties such as large surface area, low material density and good dispersion, magnetic composite hollow spheres are very attractive as catalysts [1,2], light fillers [3], microwave absorption materials [4], drug delivery systems [5][6][7], adsorption/immobilization of biomolecular materials [8,9] and magnetorheological fluids [10] in recent years. These magnetic composite hollow spheres are mainly composed of mesoporous carbon, polymer, silica and magnetic materials [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%