Magnetic Resonance Diffusion Tensor Imaging Provides New Insights Into the Microstructural Alterations in Dilated Cardiomyopathy

Nguyen, Christopher; Li, Debiao

doi:10.1161/circimaging.116.005593

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…In patients with DCM, the thickness of the myocardium was commonly decreased in the end stage, and the thin myocardium would probably cause the value of HA more sensitive to the sketched ROIs. That might have it challenged the accurate quantification of HA, resulting in the relatively lower ICC of HA [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…DTI could investigate water diffusion within the tissue and derive additional scalar metrics for quantifying structural integrity [3,4]. Consequently, CMR DTI has become a non-invasive method to illustrate the alterations of cardiac microstructure in patients with dilated cardiomyopathy (DCM), amyloidosis, and hypertrophic cardiomyopathy in recent studies [1,2,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T

Chen

et al. 2023

BMC Med Imaging

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Background The aim was to compare the diffusion tensor imaging (DTI) indices derived from human hearts between 1.5 T and 3.0 T scanners. Additionally, the reproducibility of DTI indices was assessed between 1.5 T and 3.0 T scanners. Methods A total of 18 ex-vivo hearts were derived from patients who underwent heart transplantation. The DTI schemes were performed at 1.5 T and 3.0 T, respectively. Then, the same slices from each ex-vivo heart were selected for image analysis. The student’s t-test or Wilcoxon-rank test was used to compare the statistical differences. The agreement of DTI indices was mainly reported as the interclass correlation coefficient (ICC). Results No significant differences (all P > 0.05) were found in the DTI indices between 1.5 T and 3.0 T scanners. Interestingly, the ICC of all DTI indices was relatively lower with a low b-value. The reproducibility of the helix angle (HA) was relatively lower when compared to the other DTI indices. Conclusion The DTI indices of ex-vivo human hearts between 1.5 T and 3.0 T scanners had no significant differences. The consistency of DTI indices needed caution using a low b-value with different field strengths, and the relatively low reproducibility of HA should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T

Chen

et al. 2023

BMC Med Imaging

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“…However, the long ex vivo DTI scan times (i.e., 10-12h) are prohibitive for patient studies. Thus, progress has also been made in the past years to develop and test methods (with and without motion-compensation) for in vivo DT imaging of healthy volunteers and postinfarct patients [34,35,36,37]. Although the spatial resolution needs to be substantially reduced in order for clinically acceptable scan times (<1h).…”

Section: Cardiac Dw/dt Imaging and Parametric Mapsmentioning

confidence: 99%

Diffusion Magnetic Resonance Imaging with Applications to Cardiac Muscle: Short Review

Pop

Stefu

2020

Annals of West University of Timisoara - Physics

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This review describes in brief recent magnetic resonance imaging (MRI) methods for assessing cardiac structure in healthy and pathologic state using diffusion-weighted (DW) and diffusion tensor imaging (DTI) approaches. A background on the theory and MR pulse sequences employed in DW/DT imaging is given, along with the calculation of diffusion tensor (D), apparent diffusion coefficient (ADC) and fractional anisotropy (FA). Parametric maps derived from DW/DT images can quantify microstructure alterations due to fibrotic collagen deposition, along with associated changes in cardiac muscle anisotropy. Representative examples of ADC and FA parametric maps are shown from ex vivo high-resolution DT images of explanted healthy and scarred hearts obtained from pre-clinical investigations. Furthermore, examples of fiber tractography demonstrating DTI-based 3D (three-dimensional) reconstruction of fiber directions within the heart are illustrated using advanced open-source software. Lastly, future developments and potential translation of DW/DT methods into routine clinical evaluation for cardiac MR imaging protocols are highlighted.

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Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Čelutkienė

Plymen

Flachskampf

et al. 2018

European J of Heart Fail

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Myriad advances in all fields of cardiac imaging have stimulated and reflected new understanding of cardiac performance, myocardial damage and the mechanisms of heart failure. In this paper, the Heart Failure Association assesses the potential usefulness of innovative imaging modalities in enabling more precise diagnostic and prognostic evaluation, as well as in guiding treatment strategies. Many new methods have gradually penetrated clinical practice and are on their way to becoming a part of routine evaluation. This paper focuses on myocardial deformation and three‐dimensional ultrasound imaging; stress tests for the evaluation of contractile and filling function; the progress of magnetic resonance techniques; molecular imaging and other sound innovations.The Heart Failure Association aims to highlight the ways in which paradigms have shifted in several areas of cardiac assessment. These include reassessing of the simplified concept of ejection fraction and implementation of the new parameters of cardiac performance applicable to all heart failure phenotypes; switching from two‐dimensional to more accurate and reproducible three‐dimensional ultrasound volumetric evaluation; greater tissue characterization via recently developed magnetic resonance modalities; moving from assessing cardiac function and congestion at rest to assessing it during stress; from invasive to novel non‐invasive hybrid techniques depicting coronary anatomy and myocardial perfusion; as well as from morphometry to the imaging of pathophysiologic processes such as inflammation and apoptosis. This position paper examines the specific benefits of imaging innovations for practitioners dealing with heart failure aetiology, risk stratification and monitoring, and, in addition, for scientists involved in the development of future research.

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Magnetic Resonance Diffusion Tensor Imaging Provides New Insights Into the Microstructural Alterations in Dilated Cardiomyopathy

Cited by 4 publications

References 21 publications

The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T

The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T

Diffusion Magnetic Resonance Imaging with Applications to Cardiac Muscle: Short Review

Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

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