Magnetic resonance elastography: a general overview of its current and future applications in brain imaging

Ieva, Antonio Di; Grizzi, Fabio; Rognone, Elisa; Tse, Zion Tsz Ho; Parittotokkaporn, Tassanai; Baena, Ferdinando Rodriguez y; Tschabitscher, Manfred; Matula, Christian; Trattnig, S.; Baena, Riccardo Rodriguez y

doi:10.1007/s10143-010-0249-6

Cited by 48 publications

(27 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another promising recent development for MRE is for the assessment of the mechanical properties of the tissues of the central nervous system (CNS), specifically the brain (151). Knowledge about brain tissue mechanical properties is important for understanding the mechanics of brain injury, development, and pathophysiology and could provide insight into a myriad of conditions.…”

Section: Mre Of the Brainmentioning

confidence: 99%

Review of MR elastography applications and recent developments

Glaser

Manduca

Ehman

2012

Magnetic Resonance Imaging

216

156

View full text Add to dashboard Cite

The technique of MR elastography (MRE) has emerged as a useful modality for quantitatively imaging the mechanical properties of soft tissues in vivo. Recently, MRE has been introduced as a clinical tool for evaluating chronic liver disease, but many other potential applications are being explored. These applications include measuring tissue changes associated with diseases of the liver, breast, brain, heart, and skeletal muscle including both focal lesions (e.g., hepatic, breast, and brain tumors) and diffuse diseases (e.g., fibrosis and multiple sclerosis). The purpose of this review article is to summarize some of the recent developments of MRE and to highlight some emerging applications.

show abstract

Section: Mre Of the Brainmentioning

confidence: 99%

Review of MR elastography applications and recent developments

Glaser

Manduca

Ehman

2012

Magnetic Resonance Imaging

216

156

View full text Add to dashboard Cite

show abstract

“…MRE has been applied to study many human organs, including liver (Asbach et al, 2008; Klatt et al, 2007), breast (Sinkus et al, 2005a), and brain (Clayton et al, 2012; Di Ieva et al, 2010; Green et al, 2008; Hamhaber et al, 2010; Klatt et al, 2007; McCracken et al, 2005; Sack et al, 2008; Zhang et al, 2011). The initial inversion methods of MRE were based on the assumption of linear, isotropic, elastic material behavior.…”

Section: Introductionmentioning

confidence: 99%

Viscoelastic properties of the ferret brain measured in vivo at multiple frequencies by magnetic resonance elastography

Feng¹,

Clayton²,

Chang³

et al. 2013

Journal of Biomechanics

View full text Add to dashboard Cite

Characterization of the dynamic mechanical behavior of brain tissue is essential for understanding and simulating the mechanisms of traumatic brain injury (TBI). Changes in mechanical properties may also reflect changes in the brain due to aging or disease. In this study, we used magnetic resonance elastography (MRE) to measure the viscoelastic properties of ferret brain tissue in vivo. Three-dimensional (3D) displacement fields were acquired during wave propagation in the brain induced by harmonic excitation of the skull at 400 Hz, 600 Hz and 800 Hz. Shear waves with wavelengths on the order of millimeters were clearly visible in the displacement field, in strain fields, and in the curl of displacement field (which contains no contributions from longitudinal waves). Viscoelastic parameters (storage and loss moduli) governing dynamic shear deformation were estimated in gray and white matter for these excitation frequencies. To characterize the reproducibility of measurements, two ferrets were studied on three different dates each. Estimated viscoelastic properties of white matter in the ferret brain were generally similar to those of gray matter and consistent between animals and scan dates. In both tissue types G′ increased from approximately 3 kPa at 400 Hz to 7 kPa at 800 Hz and G″ increased from approximately 1 kPa at 400 Hz to 2 kPa at 800 Hz. These measurements of shear wave propagation in the ferret brain can be used to both parameterize and validate finite element models of brain biomechanics.

show abstract

“…The clinical potential for quantitative ultrasonic elasticity imaging can be seen in the current applications of MRE [63,82–84]. A very comprehensive review of MRE has been prepared by Mariappan et al [63], which demonstrates the clinical utility of MRE in the area of diagnosing liver fibrosis without needing liver biopsy.…”

Section: Future Perspectivementioning

confidence: 99%

What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?

Palmeri¹,

Nightingale²

2011

Imaging in Medicine

View full text Add to dashboard Cite

Ultrasound elasticity imaging has been a research interest for the past 20 years with the goal of generating novel images of soft tissues based on their material properties (i.e., stiffness and viscosity). The motivation for such an imaging modality lies in the fact that many soft tissues can share similar ultrasonic echogenicities, but may have very different mechanical properties that can be used to clearly visualize normal anatomy and delineate diseased tissues and masses. Recently, elasticity imaging techniques have moved from the laboratory to the clinical setting, where clinicians are beginning to characterize tissue stiffness as a diagnostic metric and commercial implementations of ultrasonic elasticity imaging are beginning to appear on the market. This article provides a foundation for elasticity imaging, an overview of current research and commercial realizations of elasticity imaging technology and a perspective on the current successes, limitations and potential for improvement of these imaging technologies.

show abstract

Magnetic resonance elastography: a general overview of its current and future applications in brain imaging

Cited by 48 publications

References 68 publications

Review of MR elastography applications and recent developments

Review of MR elastography applications and recent developments

Viscoelastic properties of the ferret brain measured in vivo at multiple frequencies by magnetic resonance elastography

What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?

Contact Info

Product

Resources

About