Magnetic resonance elastography: basic principles, technique, and clinical applications in the liver

Akkaya, Habip Eser; Erden, Ayşe; Öz, Diğdem Kuru; Ünal, Sena; Erden, İlhan

doi:10.5152/dir.2018.18186

Cited by 33 publications

(25 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding MRI, a new but very promising contemporary imaging technique, magnetic resonance elastography (MRE), exhibits great accuracy at all stages. MRE has also exhibited fibrosis heterogenicity through the liver as it has provided significantly different stiffness values in different liver segments (Akkaya et al 2018). Although MRE is very accurate, it is costly and requires further validation (Huwart et al 2008;Carey and Carey 2010;Akkaya et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the “Reference Standard”

Gatos

Drazinos²,

Yarmenitis³

et al. 2020

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Chronic liver disease (CLD) is currently a major cause of death. Ultrasound elastography (USE) is an imaging method that has been developed for CLD assessment. Our aim in the study described here was to evaluate and compare a new commercial variant of USE, sound touch elastography (STE), with already established USE methods, shear wave elastography (SWE) and vibration-controlled transient elastography (VCTE), using liver biopsy as the "reference standard." For our study, 139 consecutive patients underwent standard liver STE, SWE and VCTE examinations with the corresponding ultrasound devices. A receiver operator characteristic (ROC) curve analysis was performed on the stiffness values measured with each method. ROC analysis revealed, for SWE, STE and VCTE, areas under the ROC curve of 0.9397, 0.9224 and 0.9348 for fibrosis stage (F), F F1; 0.9481, 0.9346 and 0.9415 for F F2; 0.9623, 0.9591 and 0.9631 for F F3; and 0.9581, 0.9541 and 0.9632 for F = F4, respectively. In conclusion, STE performs similarly to SWE and VCTE in CLD stage differentiation.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the “Reference Standard”

Gatos

Drazinos²,

Yarmenitis³

et al. 2020

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…During MRE acquisition, vibrations are continuously applied and typically range between 20 Hz and 500 Hz. 43 The response to shear waves propagating through the tissue can be measured by a specific MRI sequence, resulting in a tissue stiffness map or elastogram. By detecting the difference in wavelength between normal liver tissue and fibrotic liver tissue, MRE is highly accurate in detecting and evaluating different stages of liver fibrosis.…”

Section: T 2 *mentioning

confidence: 99%

Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease

Schaapman

Tushuizen

Coenraad

et al. 2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in the world, affecting more than 25% of the adult population. NAFLD covers a spectrum including simple steatosis, in which lipid accumulation in hepatocytes is the predominant histological characteristic, and nonalcoholic steatohepatitis (NASH), which is characterized by additional hepatic inflammation with or without fibrosis. Liver biopsy is currently the reference standard to discriminate between hepatic steatosis and steatohepatitis. Since liver biopsy has several disadvantages, noninvasive diagnostic methods with high sensitivity and specificity are desirable for the analysis of NAFLD. Improvements in magnetic resonance imaging (MRI) technology are continuously being implemented in clinical practice, specifically multiparametric MRI methods such as proton density fat-fraction (PDFF), T 2 *, and T 1 mapping, along with MR elastography. Multiparametric imaging of the liver has a promising role in the clinical management of NAFLD with quantification of fat content, iron load, and fibrosis, which are features in NAFLD. In the present article, we review the utility and limitations of multiparametric quantitative imaging of the liver for diagnosis and management of patients with NAFLD. Level of Evidence: 5. Technical Efficacy Stage: 3.

show abstract

“…Diffusion-weighted (DW) MRI, as well as ultrasound and MR-based elastography methods, can image fibrosis but are non-specific and generally have low sensitivity (Muzard et al, 2009; Talwalkar et al, 2007; Taouli et al, 2007). Ultrasound elastography can also have technical failures if obesity or ascites are present, although using MRI elastography instead may overcome this problem (Akkaya et al, 2018). Lipids can be detected in tumours by using MRI (Pokharel et al, 2013), and imaging the rate of fatty acid synthesis is possible with PET agents (Lewis et al, 2014; Schöder and Larson, 2004), but, due to the disadvantages described above, PET is not used regularly.…”

Section: Visualising the Tmementioning

confidence: 99%

Photoacoustic imaging as a tool to probe the tumour microenvironment

Brown

Brunker

Bohndiek

2019

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

The tumour microenvironment (TME) is a complex cellular ecosystem subjected to chemical and physical signals that play a role in shaping tumour heterogeneity, invasion and metastasis. Studying the roles of the TME in cancer progression would strongly benefit from non-invasive visualisation of the tumour as a whole organ in vivo , both preclinically in mouse models of the disease, as well as in patient tumours. Although imaging techniques exist that can probe different facets of the TME, they face several limitations, including limited spatial resolution, extended scan times and poor specificity from confounding signals. Photoacoustic imaging (PAI) is an emerging modality, currently in clinical trials, that has the potential to overcome these limitations. Here, we review the biological properties of the TME and potential of existing imaging methods that have been developed to analyse these properties non-invasively. We then introduce PAI and explore the preclinical and clinical evidence that support its use in probing multiple features of the TME simultaneously, including blood vessel architecture, blood oxygenation, acidity, extracellular matrix deposition, lipid concentration and immune cell infiltration. Finally, we highlight the future prospects and outstanding challenges in the application of PAI as a tool in cancer research and as part of a clinical oncologist's arsenal.

show abstract

Magnetic resonance elastography: basic principles, technique, and clinical applications in the liver

Cited by 33 publications

References 57 publications

Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the “Reference Standard”

Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the “Reference Standard”

Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease

Photoacoustic imaging as a tool to probe the tumour microenvironment

Contact Info

Product

Resources

About