Magnetic resonance elastography vs. transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease

Park, C.C.; Nguyen, Phirum; Hernandez, Carolyn; Bettencourt, Richele; Ramirez, Kim; Fortney, Lynda; Hooker, Jonathan; Sy, Ethan; Alquiraish, Mosab H.; Valasek, Mark A.; Rizo, Emily; Richards, Lisa; Brenner, David A.; Sirlin, Claude B.; Loomba, Rohit

doi:10.1016/s0168-8278(17)30769-9

Cited by 140 publications

(256 citation statements)

References 5 publications

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“…However, it can also be regarded as a measure on its own, attaining value through its predictive power as opposed to its biological interpretation. Recently, magnetic resonance (MR) elastography and spectroscopy have been shown to be accurate alternatives for non‐invasive fibrosis staging and steatosis grading . We were unable to take this technology into account because of lack of data at the time our database was created in 2015.…”

Section: Discussionmentioning

confidence: 99%

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement

Karlas¹,

Petroff²,

Sasso³

et al. 2018

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement

Karlas¹,

Petroff²,

Sasso³

et al. 2018

Aliment Pharmacol Ther

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“…ARFI was evaluated in two studies, both with high risk of bias, resulting in sensitivities of 77%‐85% and specificities of 72%‐83%, using similar cut‐off values . MRE was evaluated for NASH diagnosis in six studies, again with different NASH definitions, resulting in AUROCs ranging from 0.70 to 0.79 in studies not including fibrosis in NASH definition, with sensitivity and specificity of 72% and 87% for NAS ≥ 5 and similar results in a subset of patients without fibrosis …”

Section: Resultsmentioning

confidence: 99%

“…Non‐invasive imaging modalities such as magnetic resonance imaging (MRI) or spectroscopy (MRS) with calculation of proton density fat fraction (PDFF) accurately measure hepatic fat . On the other hand, since fibrosis is the most important histological feature associated with long‐term mortality in patients with NAFLD, research on non‐invasive tests, either serum biomarkers and imaging‐based techniques, have focused on this outcome …”

Section: Introductionmentioning

confidence: 99%

Accuracy of imaging methods for steatohepatitis diagnosis in non‐alcoholic fatty liver disease patients: A systematic review

Besutti

Valenti

Ligabue

et al. 2019

Liver International

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Abbreviations: ARFI, acoustic radiation force impulse; AUROC, area under the receiving operating characteristic curve; MRE, magnetic resonance elastography; MRS, magnetic resonance spectroscopy; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; PDFF, proton density fat fraction; QUADAS-2, Quality Assessment of Diagnostic Accuracy Studies-2; SPIO/USPIO, superparamagnetic iron oxide/ultrasmall superparamagnetic iron oxide; TE, transient elastography. AbstractBackground & Aims: Non-invasive tests to diagnose non-alcoholic steatohepatitis (NASH) are urgently needed. This systematic review aims to evaluate imaging accuracy in diagnosing NASH among non-alcoholic fatty liver disease (NAFLD) patients, using liver biopsy as reference.Methods: Eligible studies were systematic reviews and cross-sectional/cohort studies of NAFLD patients comparing imaging with histology, considering accuracy and/ or associations. MEDLINE, Scopus, EMBASE and Cochrane Library databases were searched up to April 2018. Studies were screened on title/abstract, then assessed for eligibility on full-text. Data were extracted using a predesigned form. Risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 tool. Results:Of the 641 studies screened, 61 were included in scoping review, 30 of which (with accuracy results) in data synthesis. Imaging techniques included: elastography (transient elastography-TE, acoustic radiation force impulse-ARFI, magnetic resonance elastography-MRE), ultrasound (US), magnetic resonance (MR), computed tomography and scintigraphy. Histological NASH definition was heterogeneous. In 28/30 studies, no prespecified threshold was used (high risk of bias). AUROCs were up to 0.82 for TE, 0.90 for ARFI, 0.93 for MRE and 0.82 for US scores. MR techniques with higher accuracy were spectroscopy (AUROC = 1 for alanine), susceptibility-weighted imaging (AUROC = 0.91), multiparametric MR (AUROC = 0.80), optical analysis (AUROC = 0.83), gadoxetic acid-enhanced MR (AUROCs = 0.85) and superparamagnetic iron oxide-enhanced MR (AUROC = 0.87). Results derived mostly from single studies without independent prospective validation. Conclusions:There is currently insufficient evidence to support the use of imaging to diagnose NASH. More studies are needed on US and MR elastography and non-elastographic techniques, to date the most promising methods. K E Y W O R D Smagnetic resonance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, ultrasonography

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“…In regard to the stage of fibrosis, it requires closer monitoring on fibrosis progression and intensive therapies. Biomarkers and scores of fibrosis, as well as transient elastography, are acceptable noninvasive methods for the identification of cases at low risk of advanced fibrosis. Many serum markers have shown acceptable diagnostic accuracy.…”

Section: Poor Surveillance Of Nafldmentioning

confidence: 99%

“…In selected patients at high risk of liver disease progression, monitoring should include a repeat liver biopsy after at least a 5‐year follow‐up. However, there is no consensus on score thresholds for use in clinical practice when trying to avoid liver biopsy …”

Section: Poor Surveillance Of Nafldmentioning

confidence: 99%

Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

Cai

Zhang

2018

Medicinal Research Reviews

130

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Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism-related comorbidities, which result from of a lack of awareness and poor surveillance of the disease and a paucity of approved and effective therapies. Managing the complications of NAFLD has already begun to place a tremendous burden on health-care systems. Although efforts to identify effective therapies are underway, the lack of validated preclinical NAFLD models that represent the biology and outcomes of human disease remains a major barrier. This review summarizes the characteristics and prevalence of the disease and the status of our understanding of its mechanisms and potential therapeutic targets.

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Magnetic resonance elastography vs. transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease

Cited by 140 publications

References 5 publications

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement

Accuracy of imaging methods for steatohepatitis diagnosis in non‐alcoholic fatty liver disease patients: A systematic review

Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

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