Magnetic Resonance Enterography to Assess Multifocal and Multicentric Bowel Endometriosis

Timoh, Krystel Nyangoh; Stewart, Zelda; Benjoar, Marc-David; Beldjord, Selma; Ballester, Marcos; Bazot, Marc; Thomassin‐Naggara, Isabelle; Daraı̈, Émile

doi:10.1016/j.jmig.2017.10.037

Cited by 13 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, none of our patients required a discoid or segmental colorectal resection. Moreover, in accordance with previous studies [28], appendicular endometriosis was ignored by preoperative IRM in four patients.…”

Section: Discussionsupporting

confidence: 83%

Nomogram predicting the likelihood of complications after surgery for deep endometriosis without bowel involvement

Poupon

Owen

Arfi

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Study Objective To describe complications following surgery for deep endometriosis (DE) without bowel involvement and to develop a nomogram for predicting postoperative complications. Design Retrospective study Setting Tertiary referral university hospital and expert center in endometriosis Patients Two-hundred and twenty patients with DE without bowel involvement Interventions Laparoscopic resection for DE without bowel involvement Measurements and Main Results Operative complications were evaluated using the Clavien-Dindo classification. Voiding dysfunction was defined as a need for bladder self-catheterization lasting >1 month. Fifty-three patients (24%) had postoperative complications: 31 (14%) had a Clavien-Dindo grade I—II complication (3 grade I and 28 grade II); 11 (5%) had a grade III complication (2 grade IIIa and 9 grade IIIb); and 11 (5%) had voiding dysfunction. No grade IV—V complications were observed. Age, Enzian classification risk group, and previous surgery for endometriosis were significantly associated with postoperative complications. The predictive model had an AUC of 0.72 (95% CI, 0.70–0.74) before and 0.70 (95% CI, 0.68–72) after bootstrap sample correction. The average difference and maximal difference in predicted and calibrated probabilities of recurrence were 0.023 and 0.089% respectively Conclusion Surgery for DE without bowel resection is associated with a relatively high incidence of voiding dysfunction and postoperative complications mainly corresponding to Clavien-Dindo grade I—II. Age, risk group of Enzian classification, and previous surgery for endometriosis are significantly associated with postoperative complications and voiding dysfunction. Our results allowed us to build a nomogram which can be used to better inform patients about the risk of DE surgery without bowel involvement

show abstract

Section: Discussionsupporting

confidence: 83%

Nomogram predicting the likelihood of complications after surgery for deep endometriosis without bowel involvement

Poupon

Owen

Arfi

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

show abstract

“…Bowel endometriosis may present as a multifocal disease [18] (see cases #9 and #10, Figure 2), and this has to be differentiated with familial polyposis and rectal cancer. Women with endometriosis are usually younger than patients with colonic cancer, and family history is certainly of help in cases of bowel polyposis.…”

Section: Resultsmentioning

confidence: 99%

Sonographic Differential Diagnosis in Deep Infiltrating Endometriosis: The Bowel

Scioscia

Orlandi

Trivella

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Up to one-third of fertile-age women with severe endometriosis suffer from colonic involvement. Transvaginal ultrasonography has become a first-line diagnostic tool for the study of the pelvis and more specifically for the diagnosis of pelvic endometriosis. Accuracy of pelvic ultrasound for deep endometriosis increases with operator experience, but the difficulties in the differential diagnosis with diseases that can afflict the bowel tract remain a challenge. We reviewed noteworthy cases referred for secondary level diagnosis suspected of bowel endometriosis in which the subsequent ultrasound led to an alternative diagnosis. This case series aims to highlight awareness for both experts and less-experienced operators the possible differential diagnoses of bowel lesions that initially resemble endometriosis.

show abstract

“…Endometriosis has a malignant tumour‐like aspect, especially the aggressiveness exhibited by DSIE 133,134 . Intestinal endometriosis is often multifocal and multicentric 135 . A tumour‐like appearance can sometimes be misdiagnosed as a malignant tumour of the digestive tract 136 .…”

Section: Biological Behaviour Of Dsie and Its Molecular Mechanismsmentioning

confidence: 99%

“… 133 , 134 Intestinal endometriosis is often multifocal and multicentric. 135 A tumour‐like appearance can sometimes be misdiagnosed as a malignant tumour of the digestive tract. 136 The malignant aggressiveness of DSIE is associated with collective cell migration (CCM) and EMT.…”

Section: Biological Behaviour Of Dsie and Its Mole...mentioning

confidence: 99%

Digestive system deep infiltrating endometriosis: What do we know

Yin,

Li,

Liu

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

Digestive system infiltrating endometriosis (DSIE) is an uncommon form of endometriosis in the digestive system. DSIE often occurs in the intestines (especially the sigmoid rectum), liver, gallbladder and pancreas. Clinically, DSIE presents with the same symptoms as endometriosis, including cyclic pain, bleeding and infertility, in addition to specific biliary/intestinal obstruction and gastrointestinal bleeding. Compared to general endometriosis, DSIE has unique biological behaviour and pathophysiological mechanisms. Most DSIEs are deep invasive endometrioses, characterized by metastasis to the lymph nodes and lymphatic vessels, angiogenesis, peripheral nerve recruitment, fibrosis and invasion of surrounding tissues. DSIE‐related peripheral angiogenesis is divided into three patterns: angiogenesis, vasculogenesis and inosculation. These patterns are regulated by interactions between multiple hypoxia‐hormone cytokines. The nerve growth factors regulate the extensive neurofibril recruitment in DSIE lesions, which accounts for severe symptoms of deep pain. They are also associated with fibrosis and the aggressiveness of DSIE. Cyclic changes in DSIE lesions, recurrent inflammation and oxidative stress promote repeated tissue injury and repair (ReTIAR) mechanisms in the lesions, accelerating fibril formation and cancer‐related mutations. Similar to malignant tumours, DSIE can also exhibit aggressiveness derived from collective cell migration mediated by E‐cadherin and N‐cadherin. This often makes DSIE misdiagnosed as a malignant tumour of the digestive system in clinical practice. In addition to surgery, novel treatments are urgently required to effectively eradicate this lesion.

show abstract

Magnetic Resonance Enterography to Assess Multifocal and Multicentric Bowel Endometriosis

Cited by 13 publications

References 26 publications

Nomogram predicting the likelihood of complications after surgery for deep endometriosis without bowel involvement

Nomogram predicting the likelihood of complications after surgery for deep endometriosis without bowel involvement

Sonographic Differential Diagnosis in Deep Infiltrating Endometriosis: The Bowel

Digestive system deep infiltrating endometriosis: What do we know

Contact Info

Product

Resources

About