Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee11This work is supported by NIH grant RO1 AR 46905 &amp; AG 17762.

Lindsey, Colleen T.; Narasimhan, Anita; Adolfo, J. M.; Jin, Hua; Steinbach, Lynne S.; Link, Thomas M.; Ries, Michael D.; Majumdar, Sharmila

doi:10.1016/j.joca.2003.10.009

Cited by 79 publications

(71 citation statements)

References 44 publications

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“…If ZOL treatment is initiated at this stage, abnormalities in subchondral bone can be reversed to a large extent and then cartilage degeneration would be retarded accordingly. Conversely, at an advanced stage, subchondral bone accretion was increased mainly due to excessive mechanical stress [30][31][32] . If ZOL therapy is given at this stage, subchondral bone remodeling would not be reversible, and articular cartilage degeneration would continue.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Mao

et al. 2012

Acta Pharmacol Sin

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Aim: To investigate whether the stage of osteoarthritis (OA) progression influenced the efficacy of the third-generation bisphosphonate zoledronic acid in a rat medial meniscal tear model. Methods: Medial meniscal tear (MMT) was surgically induced in adult male Sprague Dawley rats. Zoledronic acid (ZOL, 100 μg/kg, sc, twice a week) was administered starting immediately, early (from 4 weeks) or late (from 8 weeks) after OA induction. The degeneration of articular cartilage was evaluated with toluidine blue O staining. Subchondral bone remodeling was evaluated with X-ray micro-CT scanning. Joint pain was measured with respect to weight-bearing asymmetry. Calcitonin gene-related peptide (CGRP) expression in dorsal root ganglia (DRGs) was examined using immunofluorescence analysis. The afferent neurons in DRGs innervating the joint were identified by retrograde labeling with fluorogold. Results: Progressive cartilage loss was observed during 12 weeks after OA induction. Subchondral bone remodeling manifested as increased bone resorption at early stage (4 weeks), but as increased bone accretion at advanced stages (8 weeks). Immediately and early ZOL administration significantly improved subchondral microstructural parameters, attenuated cartilage degeneration, reduced weight-bearing asymmetry and CGRP expression, whereas the late ZOL administration had no significant effects. Conclusion: The stage of OA progression influences the efficacy of ZOL in treating joint degeneration and pain. To obtain the maximum efficacy, bisphosphonate treatment should be initiated in rat with early stages of OA pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Mao

et al. 2012

Acta Pharmacol Sin

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“…This group also demonstrated substantially lower vBMD at the 2% level in half the subregions. It has been surmised that lower bone density beneath the lateral compartment may simply represent disuse osteopenia (4,47). This could be due to the fact that more of the load is shifted to the medial compartment due to increasing varus malalignment and joint changes as the disease progresses (17,28,29).…”

Section: Discussionmentioning

confidence: 99%

“…MRI studies have correlated cartilage volume loss with increased bone volume fraction beneath the affected compartment, and decreased bone volume fraction beneath the unaffected compartment (4,10,11). Fractal signature analysis of macroradiographs has shown thinning of vertical trabeculae, in particular, to be characteristic of the predominantly less dense subchondral trabecular bone in OA (5,12,13).…”

mentioning

confidence: 99%

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

Bennell¹,

Creaby²,

Wrigley³

et al. 2008

Arthritis & Rheumatism

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Objective. Knee osteoarthritis (OA) is an organlevel failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral density (vBMD) of proximal tibial subchondral trabecular bone in people with and without knee OA, using peripheral quantitative computed tomography (pQCT).Methods. Seventy-five individuals with mild or moderate medial compartment knee OA and 41 asymptomatic controls were recruited. Peripheral QCT was used to measure vBMD of trabecular bone beneath medial and lateral tibiofemoral compartments at levels of 2% and 4% of tibial length, distal to the tibial plateau.Results. There was no significant difference in vBMD beneath the overall medial and lateral compartments between the 3 groups. However, in the affected medial compartment of those with moderate OA, lower vBMD was seen in the 2 posterior subregions compared with controls and those with mild knee OA, while higher vBMD was seen in the anteromedial subregion. Beneath the unaffected or lesser affected lateral compartment, significantly lower vBMD was seen at the 2% level in the anterior and lateral subregions of those with moderate disease. Volumetric BMD ratios showed relatively higher vBMD in the medial compartment compared with the lateral compartment, but these ratios were not influenced by disease status.Conclusion. Subregional vBMD changes were evident beneath the medial and lateral compartments of those with moderate medial knee OA. Of import, the posterior subchondral trabecular regions of the medial tibial plateau have markedly lower vBMD.

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“…Owing to its lack of radiation and cross-sectional nature, however, high resolution MRI is a more promising tool in assessing bone structure non-invasively, but obtaining images in vivo with a suitable spatial resolution is still challenging. Previous investigations have used 1.5 T scanners combined with surface coils dedicated for high resolution imaging for that purpose (8,13,207) and have studied the knee using high-resolution 3D gradient echo sequences. Axial fast gradient echo sequences were used with an echo (TE) of 4.5 ms, a repetition time (TR) of 30 ms, a flip angle (FA) ¼ 408, a field of view of 10 cm and a matrix size of 512 Â 384 pixels corresponding to a reconstructed spatial resolution of 0.195 mm Â 0.195 mm.…”

Section: Quantitative Measurement Of Bone Structure In Oa Hardware Anmentioning

confidence: 99%

“…Lindsey et al (207) analyzed the interrelationship of cartilage volume and trabecular bone structure in the knees of 21 healthy volunteers and 53 patients with varying degrees of OA. They found that articular cartilage thinning was associated with loss of bone structure in the opposite femoral condyle (P < 0.05).…”

Section: Cross-sectional and Longitudinal Observations In Oamentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee11This work is supported by NIH grant RO1 AR 46905 & AG 17762.

Cited by 79 publications

References 44 publications

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

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