The partial Fourier gradient-echo echo planar imaging (EPI) technique makes it possible to acquire high-resolution functional MRI (fMRI) data at an optimal echo time. This technique is especially important for fMRI studies at high magnetic fields, where the optimal echo time is short and may not be achieved with a full Fourier acquisition scheme. In addition, it has been shown that partial Fourier EPI provides better anatomic resolvability than full Fourier EPI. However, the partial Fourier gradient-echo EPI may be degraded by artifacts that are not usually seen in other types of imaging. It has been shown in recent works, that for high-resolution functional MRI (fMRI) studies, a partial Fourier acquisition scheme (1-7) is superior to full Fourier acquisition in two ways (8,9). First, the desired echo time (TE) value that provides the optimal BOLD sensitivity may not be achievable with a high-resolution full Fourier echo planar imaging (EPI) scan because of the very long acquisition window of high-resolution EPI. On the other hand, the optimal TE value can be easily achieved with partial Fourier EPI. Second, because of the significant signal decay within the long acquisition window of full Fourier EPI, the reconstructed EPI images are always blurred by the corresponding point spread function (PSF). On the other hand, the PSF of partial Fourier EPI is much sharper and thus the reconstructed images have a better anatomic resolvability.Successful applications of partial Fourier EPI to highresolution fMRI studies have been reported in several recent works (9,10). We expect that, partial Fourier EPI will continue to play a major role in future high-resolution fMRI studies especially those performed at high magnetic fields, because the optimal TE will be further shortened at high fields and it will be extremely difficult to acquire short-TE EPI data without using a partial Fourier acquisition scheme.In order to reliably and properly apply the partial Fourier EPI method to fMRI studies, it is important that we have a good understanding of its technical limitations and artifacts. However, the technical limitations and image artifacts of partial Fourier EPI, to our knowledge, have not yet been systematically investigated. Here, we use the newly developed k-space energy spectrum analysis method (11) to understand and characterize two types of artifacts in partial Fourier EPI. Alternative image reconstruction algorithms and quality control procedures are suggested to further improve the accuracy of partial Fourier EPI based fMRI studies.
A BRIEF REVIEW OF THE K-SPACE ENERGY SPECTRUM ANALYSISA brief review of the k-space energy spectrum analysis method (11) is provided here. Unlike spin-echo imaging, the image-domain phase accumulations due to the inplane susceptibility field gradients cannot be refocused in gradient-echo imaging. The gradients of image domain phase values result in the shift of the k-space echo energy peaks in gradient-echo imaging and gradient-echo EPI (12), which can be understood by the shift theorem of...