Magnetic Resonance-Guided Drug Delivery

Mikhail, Andrew S.; Partanen, Ari; Yarmolenko, Pavel S.; Venkatesan, Aradhana M.; Wood, Bradford J.

doi:10.1016/j.mric.2015.05.012

Cited by 14 publications

(12 citation statements)

References 77 publications

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“…Given the limitations of currently available chemotherapeutic approaches [1], magnetic drug targeting represents an innovative strategy that facilitates selective delivery and retention of various therapeutic agents at specific tissues [2][3][4][5][6][7]. In this approach, the prospective curative agents, bound to magnetic nanoparticles (MNPs) (ferrofluids) capable of responding to external magnetic fields, are effectively carried into the microcirculation of the tumor, thus minimizing drug accumulation in healthy peripheral tissues [8,9].…”

Section: Introductionmentioning

confidence: 99%

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Halevas

Mavroidi

Swanson

et al. 2019

Journal of Inorganic Biochemistry

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In this work novel magnetic cationic liposomal nanoformulations were synthesized for the encapsulation of a crystallographically defined ternary V(IV)-curcumin-bipyridine (VCur) complex with proven bioactivity, as potential anticancer agents. The liposomal vesicles were produced via the thin film hydration method employing N- [1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium (DOTAP) and egg phosphatidylcholine lipids and were magnetized through the addition of citric acid surface-modified monodispersed magnetite colloidal magnetic nanoparticles. The obtained nanoformulations were evaluated for their structural and textural properties and shown to have exceptional stability and enhanced solubility in physiological media, demonstrated by the entrapment efficiency and loading capacity results and the in vitro release studies of their cargo. Furthermore, the generated liposomal formulations preserved the superparamagnetic behavior of the employed magnetic core maintaining the physicochemical and morphological requirements for targeted drug delivery applications. The novel nanomaterials were further biologically evaluated for their DNA interaction potential and were found to act as intercalators. The findings suggest that the positively charged magnetic liposomal nanoformulations can generate increased concentration of their cargo at the DNA site, offering a further dimension in the importance of cationic liposomes as nanocarriers of hydrophobic anticancer metal ion complexes for the development of new multifunctional pharmaceutical nanomaterials with enhanced bioavailability and targeted antitumor activity.

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Section: Introductionmentioning

confidence: 99%

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Halevas

Mavroidi

Swanson

et al. 2019

Journal of Inorganic Biochemistry

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“…4,5 The coagulation threshold temperature of BSA can be adjusted by altering the pH of the phantom, allowing for delineation of regions heated to threshold temperatures relevant to thermal therapy. 6,7 However, precise, quantitative, and volumetric measurement of absolute temperatures using conventional TMPs requires numerous precisely placed thermocouples that may affect heating patterns during ablation, 8 distributed fiber-optic sensing systems, 9,10 or use of magnetic resonance imaging (MRI) thermometry 11,12 that is resourceand time-intensive (∼$600-700/h; MRI suite times >1 h), 13,14 limited in availability, and requires MRI compatible devices. 14 Tissue-mimicking thermochromic phantoms (TMTCPs) are tissue-mimicking materials that possess the ability to change color in response to a change in temperature.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a tissue‐mimicking thermochromic phantom for radiofrequency ablation

et al. 2016

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The TMTCP formulated for use with RFA can be used to provide quantitative temperature information in mild hyperthermic (40-45 °C), subablative (45-50 °C), and ablative (>50 °C) temperature ranges. Accurate visual or computational estimates of absolute temperatures and ablation zone geometry can be made with high spatial resolution based on TMTCP color. As such, the TMTCP can be used to assess RFA heating characteristics in a controlled, predictable environment.

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“…New tools are required to facilitate customisation of therapy based on the specific needs of individual patients. In the drug delivery paradigm, imaging may be used to identify the target and non-target anatomy or for screening, planning, monitoring, and postprocedural assessment of treatment outcome [3].…”

Section: Introductionmentioning

confidence: 99%

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

Bayford

Damaso

Neshatvar

et al. 2022

IEEE Trans. Biomed. Eng.

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Magnetic Resonance-Guided Drug Delivery

Cited by 14 publications

References 77 publications

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Evaluation of a tissue‐mimicking thermochromic phantom for radiofrequency ablation

Locating Functionalized Gold Nanoparticles Using Electrical Impedance Tomography

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