Magnetic Resonance–Guided Focused Ultrasound Surgery for Bone Metastasis: From Pain Palliation to Biological Ablation?

Eisenberg, Elon; Shay, Lilach; Keidar, Zohar; Agarwal, Amit; Militianu, Daniela

doi:10.1016/j.jpainsymman.2018.04.002

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…The duration of survival observed in this study is slightly longer than the reported median survival of 7 months by Duangmani ( 20 ), possibly due to the separate analysis conducted in our study for isolated bone metastasis and multi-organ metastasis. Various treatment methods, including conventional radiotherapy, stereotactic body radiotherapy ( 21 ), and Magnetic Resonance-Guided Focused Ultrasound Surgery ( 22 ), are effective in achieving tumor control and biological ablation for the treatment of bone metastasis. Additionally, the use of osteoclast inhibitors can help reduce the risk of bone fractures ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study

Li,

Pan,

Song

et al. 2024

Front. Med.

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BackgroundAdenocarcinoma is a common histological subtype of cervical cancer, accounting for 10–15% of all cases. The prognosis of cervical adenocarcinoma with distant organ metastases remains unclear. Therefore, our study aimed to investigate the patterns and prognosis of distant organ metastasis in cervical adenocarcinoma.MethodsWe obtained data from the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2010 to 2019. Cox regression, Kaplan–Meier, and log-rank analyses were conducted.ResultsWe observed that adenocarcinoma (AC) of the cervix primarily metastasizes to single organs, with a rate of 73.3%. The lungs are the most common organs of metastasis, followed by the liver and bones. Patients with bone metastases have a median survival period of 12 months, which is slightly longer compared to metastasis in other organs. Distant organ metastasis, age, positive lymph nodes, higher AJCC stages, larger tumor diameter, and higher cell grades are related to poor prognosis (p < 0.001). Furthermore, we have observed that surgical intervention, radiotherapy, and chemotherapy can potentially provide benefits for patients with distant organ metastases.ConclusionMetastasis is an independent prognostic factor for cervical adenocarcinoma patients. Surgery, radiotherapy, and chemotherapy can provide an overall survival advantage for patients with distant organ metastases.

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Section: Discussionmentioning

confidence: 99%

Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study

Li,

Pan,

Song

et al. 2024

Front. Med.

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“…382 Eisenberg et al described a cervical cancer patient who received magnetic resonance-guided focused ultrasound surgery (MRgFUS) for iliac bone metastasis. 383 In this case, MRgFUS led to a dramatic reduction in pain, and percutaneous cementoplasty was thus not considered. MRgFUS is a noninvasive surgical procedure that is effective in controlling bone metastasis-related pain in multiple clinical trials.…”

Section: Surgerymentioning

confidence: 91%

Molecular mechanisms and clinical management of cancer bone metastasis

et al. 2020

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As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoclasts, together maintain the homeostasis of the bone microenvironment. In contrast, tumor-derived factors act on bone components, leading to subsequent bone resorption or excessive bone formation. The various pathways involved also provide multiple targets for therapeutic strategies against bone metastases. In this review, we summarize the current understanding of the mechanism of bone metastases. Based on the general process of bone metastases, we specifically highlight the complex crosstalk between tumor cells and the bone microenvironment and the current management of cancer bone metastases.

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“…At 4-6 weeks after US-HIFU, no abnormal accumulation of activity at tumor sites [23]. In a patient with mixed lytic-sclerotic lesion at the iliac bone, no FDG uptake was observed at 3 months after MR-HIFU treatment (Figure 5) [32]; meanwhile, in a separate case study involving an osteolytic lesion at the iliac bone, a 35.1% decrease in standard uptake value (SUV) was noted at 3 months after MR-HIFU treatment [21], confirming tumor response in both cases. Using the PET response criteria in solid tumors (PERCIST 1.0), another study reported PR in 5 out of 12 patients and SD in 2 out of 12 patients; 4 out of 12 patients had PD at a median follow-up of 90 days after MR-HIFU [27].…”

Section: Treatment Of Bone Metastasismentioning

confidence: 96%

High Intensity Focused Ultrasound for Treatment of Bone Malignancies—20 Years of History

Yeo

Bratke

Grüll

2022

Cancers

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High Intensity Focused Ultrasound (HIFU) is the only non-invasive method for percutaneous thermal ablation of tissue, with treatments typically performed either under magnetic resonance imaging or ultrasound guidance. Since this method allows efficient heating of bony structures, it has found not only early use in treatment of bone pain, but also in local treatment of malignant bone tumors. This review of 20 years of published studies shows that HIFU is a very efficient method for rapid pain relief, can provide local tumor control and has a very patient-friendly safety profile.

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Magnetic Resonance–Guided Focused Ultrasound Surgery for Bone Metastasis: From Pain Palliation to Biological Ablation?

Cited by 5 publications

References 26 publications

Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study

Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study

Molecular mechanisms and clinical management of cancer bone metastasis

High Intensity Focused Ultrasound for Treatment of Bone Malignancies—20 Years of History

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