Magnetic resonance imaging and spectroscopy in fetal ethanol exposed Macaca nemestrina

Astley, Susan J.; Weinberger, Edward; Shaw, Dennis; Richards, Todd L.; Clarren, Sterling K.

doi:10.1016/0892-0362(95)00012-g

Cited by 24 publications

(48 citation statements)

References 28 publications

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“…Currently, there are only three pertinent studies [28][29][30] , shown in Table 5. All three studies differ regarding voxel localization, which makes it more difficult to compare results.…”

Section: Methodsmentioning

confidence: 99%

“…In the present study, a decision was made to sequentially use single voxels in different regions. Astley et al 28 also employed a single voxel technique. Currently, this is the most frequently used 1h-Mrs technique, as it is easier to obtain and it offers a more effective water and fat suppression 31 .…”

Section: Methodsmentioning

confidence: 99%

“…Astley et al 28 obtained MrI and 1h-Mrs in a group of 20 pig-tailed macaque primates that underwent experimentally induced and controlled fetal exposure to alcohol, in comparison with a control group of equal size. Neuroimaging was performed while all animals were 2.4-4.1 year-old, which would be equivalent to human adolescence, in order to assess long-term effects of alcohol.…”

Section: Methodsmentioning

confidence: 99%

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Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Gonçalves

Vasconcelos

Faleiros

et al. 2009

Arq. Neuro-Psiquiatr.

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-Objective: To analyze the metabolic constitution of brain areas through proton magnetic resonance spectroscopy in children affected with fetal alcohol spectrum disorder compared with normal children. Method: The sample of this case-control study included eight boys with epidemiologic history of in utero exposure to alcohol (median age 13.6±3.8 years) who were diagnosed with fetal alcohol spectrum disorder, and eight controls (median age 12.1±3,4 years). An 8 cm 3 single voxel approach was used, with echo time 30 ms, repetition time 1500 ms, and 128 acquisitions in a 1.5T scanner, and four brain areas were analyzed: anterior cingulate, left frontal lobe, left striatum, and left cerebellar hemisphere. Peaks and ratios of metabolites N-acetylaspartate, choline, creatine, and myo-inositol were measured. Results: Children with fetal alcohol spectrum disorder showed a decrease in choline/creatine ratio (p=0.020) in left striatum and an increase in myo-inositol/creatine ratio (p=0.048) in left cerebellum compared with controls. There was no statistically significant difference in all peaks and ratios from the anterior cingulate and frontal lobe between the two groups. Conclusion: This study found evidence that the left striatum and left cerebellum are affected by intrauterine exposure to alcohol. Additional studies with larger samples are necessary to expand our knowledge of the effects of fetal exposure to alcohol.Key words: fetal alcohol syndrome, alcohol-induced disorders of the nervous system, ethanol, fetal development, magnetic resonance spectroscopy. espectroscopia por ressonância magnética de prótons em crianças com transtornos do espectro alcoólico fetal resumo -Objetivo: Analisar a composição metabólica de áreas encefálicas através da espectroscopia de prótons por ressonância magnética em crianças com transtornos do espectro alcoólico fetal e crianças normais. Método: A amostra deste estudo de casos-controles incluiu 8 meninos com história epidemiológica de exposição fetal ao álcool (idade mediana 13,6±3,8 anos), diagnosticados com transtorno do espectro alcoólico fetal, e 8 controles (idade mediana 12,1±3,4 anos). Utilizou-se voxel único de 8 cm³, tempo de eco 30 ms, tempo de repetição 1.500 ms, 128 aquisições, em scanner de 1,5T para as seguintes áreas: cíngulo anterior, lobo frontal esquerdo, estriado esquerdo e hemisfério cerebelar esquerdo. estudaram-se os picos e as razões dos metabólitos N-acetilaspartato, colina, creatina e o mio-inositol. Resultados: As crianças acometidas apresentaram diminuição da razão colina/creatina (p=0,020) no estriado esquerdo, e aumento da razão mio-inositol/creatina (p=0,048) no cerebelo esquerdo. Não houve diferença estatisticamente significativa nos valores encontrados no cíngulo anterior e lobo frontal entre os dois grupos. Conclusão: este estudo encontrou evidências de que o estriado e o cerebelo esquerdos são acometidos pela exposição intra-uterina ao álcool. estudos adicionais com amostras maiores são essenciais para expandir nosso conhecimento dos efeitos d...

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“…Currently, there are only three pertinent studies [28][29][30] , shown in Table 5. All three studies differ regarding voxel localization, which makes it more difficult to compare results.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Gonçalves

Vasconcelos

Faleiros

et al. 2009

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…MRS can provide more sensitive indicators of underlying abnormalities in brain metabolism when structural aberrations are absent or undetectable [90]. Common brain metabolites of interest include N-acetyl aspartate (NAA), Creatine (Cr) and Choline (Cho).…”

Section: Detection Of Brain Metabolite Changes Using Mrsmentioning

confidence: 99%

“…Rodent models offer advantages of lower cost, shorter gestational time (21 days in mice and rats compared to 23 to 26 weeks in nonhuman primates) [90] and ease of handling. The three weeks of gestation in mice corresponds approximately to the first and second trimester in humans in terms of brain development.…”

Section: Accepted Manuscript 25 3 Radiological Studiementioning

confidence: 99%

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Nguyen

Chong

Tieng

et al. 2017

Magnetic Resonance Imaging

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Number of axons in the corpus callosum of the mature Macaca nemestrina: Increases caused by prenatal exposure to ethanol

1999

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The effects of prenatal exposure to ethanol on the number of callosal axons were examined. Pregnant Macaca nemestrina were treated with ethanol (1.8 g/kg b.wt.) 1 day per week during the first 6 weeks (Et6) or full 24 weeks (Et24) of gestation. Control macaques were intubated with an isocaloric amount of sucrose water (Ct). The mid‐sagittal area of the corpus callosum in 4‐ to 5‐year‐old offspring was examined in magnetic resonance (MR) images and in fixed brains. The number of callosal axons was determined by using electron microscopy. In both MR images and fixed brains of macaques treated with ethanol, the corpus callosum was 26% larger than in the controls. The rostral portion was particularly affected by ethanol; it was 55% larger in Et6‐ and Et24‐treated macaques. Axonal size and myelin thickness were unaffected by ethanol, but ethanol‐treated macaques had more callosal axons (13.7 × 107) than did controls (9.4 × 107 axons). The increase in the rostral corpus callosum suggests that parietal and frontal cortices are particularly susceptible to ethanol. The altered callosal connectivity may be a component of the structural abnormalities that underlie executive processing problems associated with fetal alcohol syndrome. J. Comp. Neurol. 412:123–131, 1999. © 1999 Wiley‐Liss, Inc.

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Magnetic resonance imaging and spectroscopy in fetal ethanol exposed Macaca nemestrina

Cited by 24 publications

References 28 publications

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Radiological studies of fetal alcohol spectrum disorders in humans and animal models: An updated comprehensive review

Number of axons in the corpus callosum of the mature Macaca nemestrina: Increases caused by prenatal exposure to ethanol

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