Magnetic resonance imaging as a diagnostic tool for breast cancer in premenopausal women

Wright, Heather Harris; Listinsky, Jay J.; Rim, Alice; Chellman-Jeffers, Melanie; Patrick, Rebecca J.; Rybicki, Lisa; Kim, Julian A.; Crowe, Joseph P.

doi:10.1016/j.amjsurg.2005.06.014

Cited by 33 publications

(24 citation statements)

References 33 publications

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“…This work was partially supported by a New York University Department of Radiology Seed grant and was presented in part at the 53rd Annual Meeting of the Society of Nuclear Medicine, San Diego, California, June [3][4][5][6][7] 2006.…”

Section: Acknowledgmentsmentioning

confidence: 99%

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Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Moy

Ponzo²,

Noz³

et al. 2007

Journal of Nuclear Medicine

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MRI is a sensitive method for detecting invasive breast cancer, but it lacks specificity. To examine the effect of combining PET with MRI on breast lesion characterization, a prototype positioning device was fabricated to allow PET scans to be acquired in the same position as MRI scans-that is, prone. Methods: To test the hypothesis that fusion of 18 F-FDG PET and MRI scans improves detection of breast cancer, 23 patients with suspected recurrent or new breast cancer underwent a routine whole-body PET scan, a prone PET scan of the chest, and a routine breast MRI scan. The attenuation-corrected prone PET and MRI datasets were registered twice by different operators. The fusion results were judged for quality by visual inspection and statistical analysis. A joint reading of the MRI and PET scans side by side and integrated images was performed by a nuclear medicine physician and a radiologist. Sensitivity and specificity of MRI and combined MRI and PET scans were calculated on the basis of pathology reports or at least 1 y of clinical and radiologic follow-up. Results: All fusions were verified to be well matched using specific anatomic criteria. A total of 45 lesions was assessed. Lesion size range was 0.6 to 10.0 cm. Of the 44 breasts examined, 29 were suspicious for cancer, of which 15 were found to be positive on surgical excision. In lesion-by-lesion analysis, sensitivity and specificity of MRI alone were 92% and 52%, respectively; after MRI and PET fusion, they were 63% and 95%, respectively. The positive predictive value and the negative predictive value for MRI alone were 69% and 85%, respectively; after MRI and PET fusion, they were 94% and 69%, respectively. Conclusion: Acquisition of prone PET scans using the new positioning device permitted acquisition of prone scans suitable for fusion with breast MRI scans. Fused PET and MRI scans increased the specificity of MRI but decreased the sensitivity in this small group of patients. Additional data are needed to confirm the statistical significance of these preliminary findings.

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Section: Acknowledgmentsmentioning

confidence: 99%

“…Pri or studies have demonstrated that breast MRI may be used to detect breast cancers that are occult on mammography, sonography, and clinical breast examination (1)(2)(3). MRI has a high sensitivity for identifying tissue abnormalities, but the reported specificities are variable (4,5).…”

mentioning

confidence: 99%

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Moy

Ponzo²,

Noz³

et al. 2007

Journal of Nuclear Medicine

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“…Yet the vast majority ($90%) of women in this age group who develop breast cancer do not have any established risk factors [8][9][10]. In addition, both MRI and ultrasound have been studied as possible screening modalities for young women; however, the expense, invasiveness and reduced specificity of MRI, and the time-consuming, operator-dependent nature of ultrasound render both unsuitable for initial population-based screening of average risk women [11,12]. However, the role of these modalities in screening and detecting breast cancer in women who are at increased risk or who exhibit certain symptoms has grown substantially, and is expected to continue to evolve.…”

Section: Introductionmentioning

confidence: 97%

Electrical impedance scanning as a new breast cancer risk stratification tool for young women

Stojadinovic

Nissan

Shriver

et al. 2007

Journal of Surgical Oncology

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“…In this context, F-18-FDG PET [2][3][4][5] and highresolution and dynamic contrast-enhanced MRI [6][7][8][9][10][11] have steadily gained acceptance in addition to X-ray mammography and ultrasonography. Initial experience with combined PET (functional imaging) and MRI (anatomical localization) has yielded positive results, providing benefits compared to either modality alone [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Novel Genetic Algorithm Generated Schemes for Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) Image Fusion

Baum

Schmidt²,

Rafferty

et al. 2011

J Digit Imaging

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The use and benefits of a multimodality approach in the context of breast cancer imaging are discussed. Fusion techniques that allow multiple images to be viewed simultaneously are discussed. Many of these fusion techniques rely on the use of color tables. A genetic algorithm that generates color tables that have desired properties such as satisfying the order principle, the rows, and columns principle, have perceivable uniformity and have maximum contrast is introduced. The generated 2D color tables can be used for displaying fused datasets. The advantage the proposed method has over other techniques is the ability to consider a much larger set of possible color tables, ensuring that the best one is found. We asked radiologists to perform a set of tasks reading fused PET/ MRI breast images obtained using eight different fusion techniques. This preliminary study clearly demonstrates the need and benefit of a joint display by estimating the inaccuracies incurred when using a side-by-side display. The study suggests that the color tables generated by the genetic algorithm are good choices for fusing MR and PET images. It is interesting to note that popular techniques such as the Fire/Gray and techniques based on the HSV color space, which are prevalent in the literature and clinical practice, appear to give poorer performance.

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Magnetic resonance imaging as a diagnostic tool for breast cancer in premenopausal women

Cited by 33 publications

References 33 publications

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Electrical impedance scanning as a new breast cancer risk stratification tool for young women

Evaluation of Novel Genetic Algorithm Generated Schemes for Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) Image Fusion

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