Magnetic resonance imaging characteristics of granulomatous mastitis

Chu, Amanda N.; Seiler, Stephen; Hayes, Jody C.; Wooldridge, Rachel; Porembka, Jessica H.

doi:10.1016/j.clinimag.2017.03.012

Cited by 17 publications

(11 citation statements)

References 10 publications

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“…Although GLM lesions demonstrated a wide spectrum of MRI findings, they typically appeared as NME [2, 19–22]. The proportion of clinically noninflammatory GLM showing NME in this study was comparable to that in the study by Aslan et al [21] (31/33, 93.9% vs. 33/36, 92.3%).…”

Section: Discussionsupporting

confidence: 81%

“…The internal enhancement was categorized as absence or presence of a clustered enhanced ring (regardless of the size of rings), and ring size was documented as the long diameter of the largest ring in the lesion. The initial increase (slow/intermediate, fast) and kinetic characteristics (persistent, plateau/washout) were based on BI-RADS 5th edition [19]. For a mass-like lesion, the evaluation was based on the descriptors of the 5th BI-RADS MRI lexicon.…”

Section: Methodsmentioning

confidence: 99%

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Differentiation between Clinically Noninflammatory Granulomatous Lobular Mastitis and Noncalcified Ductal Carcinoma in situ Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Luo

Yu³

2020

Breast Care

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Introduction: Challenges in differentiation between clinically noninflammatory granulomatous lobular mastitis (GLM) and noncalcified ductal carcinoma in situ (DCIS) remain. Objective: To identify the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) characteristics contributing to their differential diagnosis. Methods: A total of 33 clinically noninflammatory GLM and 36 noncalcified DCIS were retrospectively analyzed in the study. Internal enhancement of a nonmass enhancement (NME) lesion was divided into clustered enhanced ring (absence/presence), and clustered enhanced ring (presence) was further classified as small and large ring based on the optimal cutoff value. The 5th Breast Imaging and Data System MRI descriptors were used for assessing the other DCE-MRI characteristics. Multivariate analysis including variables with significant differences in univariate analyses was conducted to identify the independent predictors. The discriminative abilities of different predictors and their combination were compared by area under the receiver-operating characteristic curves (AUCs). Results: An NME lesion was seen more commonly in clinically noninflammatory GLM than in noncalcified DCIS (p = 0.003). DCE-MRI characteristics with significant differences in univariate analyses included NME size, clustered enhanced ring (ab-sence/presence), ring size, initial increase and kinetic characteristics for the differentiation between these two entities presenting as NME lesion. Clustered enhanced ring (presence) was further classified as small (≤7 mm) or large ring (> 7 mm). Multivariate analysis revealed that internal enhancement and initial increase were identified as significant independent predictors, and the AUC of their combination achieved the highest value of 0.867 (95% CI, 0.748-0.943). Conclusions: An NME lesion with a large ring is more highly suggestive of clinically noninflammatory GLM.

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Section: Discussionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Differentiation between Clinically Noninflammatory Granulomatous Lobular Mastitis and Noncalcified Ductal Carcinoma in situ Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Luo

Yu³

2020

Breast Care

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“…Edematous inflammation features in the peripheral parenchyma were common findings [ 45 ]. Associated features on MRI, including skin thickening, skin retraction, and nipple retraction have also been described [ 8 , 46 , 49 ] ( Fig. 10 , Fig.…”

Section: Diagnosismentioning

confidence: 98%

Assertive clinical practice in managing patients with idiopathic granulomatous mastitis: Review of literature

Alsaleh

2021

Annals of Medicine and Surgery

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Idiopathic granulomatous mastitis (IGM) is a benign persistent inflammatory breast entity characterized histologically by lobulo centric granulomas. Diagnosis may be difficult and involves a strong index of suspicion. There are plentiful studies are published which render the disease more frequently than expected. The strategy for imaging IGM depends on patient age, clinical manifestations, and risk factors. Patients have an excellent prognosis when they are appropriately treated. The management remains contentious, good judgment is required to ensure optimum treatment form and timing.

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“…Additionally, total number of the cases in these studies was very small. 7,9,23,26,30,[34][35][36] The authors concluded that there was no characteristic imaging findings due to the wide spectrum of imaging findings of IGM; and non-enhanced or diffusion weighted MRI is not helpful to differentiate IGM from malignant lesions. 24,33,34 MRI should not be a cause of delay in histopathological diagnosis of suspected cases.…”

Section: Magnetic Resonance Imaging In Igmmentioning

confidence: 99%

Use of Imaging for the Diagnosis of Idiopathic Granulomatous Mastitis: A Clinician's Perspective

Hasbahçeci

Kadıoğlu²

2018

J Coll Physicians Surg Pak

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Idiopathic granulomatous mastitis (IGM) is an inflammatory breast disease with unknown etiology and nonspecific symptoms. Differentiation of breast cancer from granulomatous disease is a diagnostic and clinical challenge. Imaging features and decision of the surgeon, based on these findings, may be important steps during diagnosis and follow-up period. Articles in association with imaging of IGM were evaluated using a PubMed search in August, 2017. Hypo-echoic or heterogeneous mass/es with or without tubular extensions were the most common ultrasonographic findings. Focal asymmetric density with or without skin thickening and parenchymal distortion were detected in most of the patients during mammography. Magnetic resonance imaging most commonly revealed focal or diffuse asymmetrical signal intensity changes without significant mass effect. Although a specified and standardised criteria list for each type of the imaging modality has been lacking, the most commonly detected imaging findings, especially in cases of multiple lesions in accordance with the decision of the surgeon and/or clinician, can be used for the diagnosis and follow-up of IGM with acceptable safety margins. However, in the presence of any suspicious findings during imaging or clinical examination, histopathological analysis should be performed.

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Magnetic resonance imaging characteristics of granulomatous mastitis

Cited by 17 publications

References 10 publications

Differentiation between Clinically Noninflammatory Granulomatous Lobular Mastitis and Noncalcified Ductal Carcinoma in situ Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Differentiation between Clinically Noninflammatory Granulomatous Lobular Mastitis and Noncalcified Ductal Carcinoma in situ Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Assertive clinical practice in managing patients with idiopathic granulomatous mastitis: Review of literature

Use of Imaging for the Diagnosis of Idiopathic Granulomatous Mastitis: A Clinician's Perspective

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