Magnetic resonance imaging characteristics of invasive breast cancer in women aged less than 35 years

Kim, Jin Joo; Lee, Suck Hong; Lee, Ji Won; Kim, Suk; Choo, Ki Seok

doi:10.1177/0284185114542365

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…In a previous study, young patients under 35 years of age were more likely to display a round/oval or lobular mass shape, a smooth mass margin, and a high signal intensity on T2-weighted images when compared to the relatively older patient group of 35 to 45 year-olds (24). However, our series showed that only 17% of lesions had round or oval shapes, and 29% had circumscribed margins.…”

Section: Discussioncontrasting

confidence: 62%

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Kim

Jang

Kim

et al. 2017

J Korean Soc Radiol

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Purpose:To evaluate the clinicopathological and imaging features of mammography, ultrasonography, and magnetic resonance imaging (MRI) for breast cancer in Korean women under 40 years of age according to molecular subtypes. Materials and Methods:We included 183 breast cancers in 176 consecutive women under 40 years old who had been diagnosed with breast cancer between January 2012 and November 2014. The patients' clinical and pathologic records were available as electronic medical records. A retrospective review of the pre-operative imaging studies was performed with 177 mammographies, 183 ultrasonographies, and 178 MRIs. Results: Eighty-six percent (158/183) of lesions were symptomatic, with masses (147/183) as the most common presentation. Eighty percent (22/25) of the asymptomatic lesions were diagnosed via screening ultrasonography. The luminal A subtype was the most common (n = 79, 43%), human epidermal growth factor receptor 2-enriched subtype showed indistinct margins on mammography (p = 0.006), the triple negative subtype depicted a posterior enhancement on ultrasonography (p < 0.001) and rim enhancement on MRI (p < 0.001). Conclusion: Breast cancers in Korean women under 40 years of age are commonly presented with a palpable mass, and luminal A is the most common molecular subtype. In our study, the imaging and pathologic characteristics of breast cancer in younger women were similar to those previously reported for older patients.

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Section: Discussioncontrasting

confidence: 62%

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Kim

Jang

Kim

et al. 2017

J Korean Soc Radiol

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“…These results of our study confirm findings from prior studies [17,18] in that breast cancers in the young were most commonly mass-type lesions with an irregular shape, irregular margins and heterogeneous enhancement in the washout kinetic curve, which do not differ from the results obtained in general populations. Recently, Kim et al [19] evaluated the MRI findings in young women (<35 years), and they concluded that a lobular shape and smooth mass margin were independently associated with young age-onset breast cancer. In their study, breast cancer in women aged less than 35 years was most commonly mass type (71.4%) with a round/oval shape (62.5%), smooth margins (55%), and heterogeneous enhancement (45%) with a washout kinetic curve (64.3%).…”

Section: Discussionmentioning

confidence: 99%

“…The revised BI-RADS provides uniform terminology in the lexicon across all three imaging modalities: mammography, ultrasound (US), and magnetic resonance imaging (MRI) [16]. There have been several reports on the radiological features of breast cancer in young women with different age cut-offs [17][18][19], but most studies did not use the revised BI-RADS.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes

Kim

Kang

et al. 2015

European Journal of Radiology

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“…These and other factors contribute to younger women having larger and more advanced tumours at the time of diagnosis, compared with older women. 6,7 Several studies have reported the imaging features of breast cancer in young women with different age cutoffs of 35 or 40 years [8][9][10][11][12][13][14][15][16][17][18] ; however, the imaging features of breast cancer in women aged of ≤30 years have not been fully characterised. Therefore, the purpose of the present study was to identify and describe the imaging, clinicopathological, and biological characteristics of breast cancer in women aged ≤30 years, and to correlate imaging features with clinical and molecular prognostic factors of invasive breast cancer in this age-group.…”

Section: Introductionmentioning

confidence: 99%

Characteristic Features of Breast Cancer in Women Aged ≤30 Years

Lee

Kuzmiak²,

Cho

et al. 2019

Hong Kong Journal of Radiology

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Objective:To identify and describe the imaging, clinicopathological and biological characteristics of breast cancer for women aged ≤30 years and to correlate the imaging features with clinical and molecular prognostic factors of breast cancer. Methods: A total of 47 women aged ≤30 years with diagnosed breast cancer were included in this study. The patients' clinic visit, radiology, and pathology reports were retrospectively reviewed. We analysed the associations between features and outcomes using Fisher's exact test. Results: The most common ultrasonographic feature was a mass with suspicious features for malignancy, which was assessed as Breast Imaging-Reporting and Data System (BI-RADS) category 4 (82. 2%, 37 / 45) or 5 (17.8%, 8 / 45) in all cases. Of the invasive tumours, 69.0% (29 / 42) had a high histological grade, 61.4% (27 / 44) were oestrogen receptor-positive, 56.8% (25 / 44) were progesterone receptor-positive, and 25.6% (11 / 43) were human epidermal growth factor receptor type 2-positive. There was a significant correlation between mammographic mass margin and BRCA mutation (p = 0.0217); ultrasonographic mass features including margin, echo pattern, posterior feature and hormone receptor status (p = 0.0117-0.0467); and BI-RADS assessment and lymph node metastasis (p = 0.0076). BRCA mutation positive correlated significantly with a high histological grade (p = 0.0243) of tumour. Conclusion: Breast cancer in women aged ≤30 years more frequently presents as a palpable mass with malignant imaging features and a high histological grade. The imaging and clinical features are significantly associated with prognostic factors of breast cancer in this patient population.

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Magnetic resonance imaging characteristics of invasive breast cancer in women aged less than 35 years

Abstract: MR morphologic features, including lobular mass shape and smooth mass margin, were independently associated with breast cancer in young women, in addition to positive axillary nodal status and higher p53 expression status.

Cited by 7 publications

References 28 publications

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Clinicopathological and Imaging Features of Breast Cancer in Korean Women under 40 Years of Age

Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes

Characteristic Features of Breast Cancer in Women Aged ≤30 Years

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