Magnetic Resonance Imaging Detection of an Experimental Pulmonary Perfusion Deficit Using a Macromolecular Contrast Agent Polylysine-Gadolinium-DTPA40

Berthezène, Yves; Vexler, Vladimir; Price, David C.; Wisner-dupon, Jean; Moseley, Michael E.; Aicher, Klaus P.; Brasch, Robert C.

doi:10.1097/00004424-199205000-00004

Cited by 55 publications

(23 citation statements)

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“…The use of blood pool MR contrast agents might be a potential solution for this dilemma as they provide an increased T1 relaxivity compared to conventional extracellular MR contrast agents. Only a few studies have evaluated the use of blood pool MR contrast agents for contrast-enhanced pulmonary perfusion MRI [19,20]. Similarly to those studies, using Gadomer for perfusion MRI, we achieved a higher SNR of the lung parenchyma than with Gd-DTPA.…”

Section: Discussionmentioning

confidence: 61%

3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

et al. 2004

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The purpose of this study was to assess the feasibility of contrast-enhanced 3D perfusion MRI and MR angiography (MRA) of pulmonary embolism (PE) in pigs using a single injection of the blood pool contrast Gadomer. PE was induced in five domestic pigs by injection of autologous blood thrombi. Contrast-enhanced first-pass 3D perfusion MRI (TE/TR/FA: 1.0 ms/2.2 ms/40 degrees; voxel size: 1.3 x 2.5 x 4.0 mm3; TA: 1.8 s per data set) and high-resolution 3D MRA (TE/TR/FA: 1.4 ms/3.4 ms/40 degrees; voxel size: 0.8 x 1.0 x 1.6 mm3) was performed during and after a single injection of 0.1 mmol/kg body weight of Gadomer. Image data were compared to pre-embolism Gd-DTPA-enhanced MRI and post-embolism thin-section multislice CT (n = 2). SNR measurements were performed in the pulmonary arteries and lung. One animal died after induction of PE. In all other animals, perfusion MRI and MRA could be acquired after a single injection of Gadomer. At perfusion MRI, PE could be detected by typical wedge-shaped perfusion defects. While the visualization of central PE at MRA correlated well with the CT, peripheral PE were only visualized by CT. Gadomer achieved a higher peak SNR of the lungs compared to Gd-DTPA (21 +/- 8 vs. 13 +/- 3). Contrast-enhanced 3D perfusion MRI and MRA of PE can be combined using a single injection of the blood pool contrast agent Gadomer.

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Section: Discussionmentioning

confidence: 61%

3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

et al. 2004

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“…In a prospective comparative study with perfusion lung scintigraphy, perfusion MRI had an average sensitivity of 69% and specificity of 91% for the detection of perfusion defects. The overall agreement between MR and scintigraphy appeared to be good (kappa_0.63) [20]. MR perfusion imaging was also capable to demonstrate physiological preferences of pulmonary perfusion.…”

Section: Perfusionmentioning

confidence: 83%

Functional MRI of the Lung

Berthezène

2010

TONMEDJ

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Abstract:Imaging of the pulmonary parenchyma represents a unique challenge for MRI. Limited signal is caused by low proton density, susceptibility artefacts, and physiological motion (cardiac pulsation, respiration). Improvements in MRI techniques have extended the potential for investigations of pulmonary parenchymal disease with the evaluation of lung perfusion. More recently inhalation of non proton-MRI nuclei such as hyperpolarized gases (3He or 129Xe) can provide functional ventilation images.

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“…Paramagnetic contrast media have the potential to increase the MR signal from the lungs when using very short TE. The very short TE offers several advantages [3,4] and particularly minimizes signal loss from the T2* of lung parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Evolution of pulmonary perfusion defects demonstrated with contrast-enhanced dynamic MR perfusion imaging

1999

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Pulmonary perfusion defects can be demonstrated with contrast-enhanced dynamic MR perfusion imaging. We present the case of a patient with a pulmonary artery sarcoma who presented with a post-operative pulmonary embolus and was followed in the post-operative period with dynamic contrast-enhanced MR perfusion imaging. This technique allows rapid imaging of the first passage of contrast material through the lung after bolus injection in a peripheral vein. To our knowledge, this case report is the first to describe the use of this MR technique in showing the evolution of peripheral pulmonary perfusion defects associated with pulmonary emboli.

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Magnetic Resonance Imaging Detection of an Experimental Pulmonary Perfusion Deficit Using a Macromolecular Contrast Agent Polylysine-Gadolinium-DTPA40

Cited by 55 publications

References 0 publications

3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

Functional MRI of the Lung

Evolution of pulmonary perfusion defects demonstrated with contrast-enhanced dynamic MR perfusion imaging

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