Magnetic resonance imaging evaluation of the effects of cigarette and maras powder (smokeless tobacco) on lumbar disc degeneration

Doğan, Adil; DOĞAN, Kamil; Taşolar, Sevgi

doi:10.1016/j.clineuro.2019.105500

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Intervertebral discs of smoke-exposed animals also showed a decrease in proteoglycan content and a decrease in prostaglandin synthesis [ 52 ]. The negative effect of cigarette smoking on intervertebral disc degenerative changes on MR imaging was also confirmed by Dogan et al [ 53 ]. The relationship between bone marrow fat content and skeletal health has attracted widespread interest among researchers.…”

Section: Discussionsupporting

confidence: 55%

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Jakoniuk

Kochanowicz

Lankau

et al. 2022

IJERPH

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Macronutrients and toxic elements may play an important role in the pathogenesis of osteoarthritis of the spine. The objective of this study was to evaluate the relationship between the concentrations of Ca, Mg, Pb, Cd and Hg in blood with the results of hydrogen magnetic resonance spectroscopy and the severity of pain. Patients with osteoarthritis of the spine (n = 90) and control subjects (n = 40) were studied. The concentrations of mineral components in blood were determined by atomic absorption spectrometry (ASA). Spinal pain severity was assessed using the Visual Analog Scale (VAS). Hydrogen magnetic resonance spectroscopy (1H-MRS) was used to determine the fat/water ratio in the bodies of L1, L5 and the L4/5 intervertebral disc. The median concentration of Mg in the serum of subjects with spinal degenerative disease was significantly lower (p < 0.001) than that in healthy subjects. The median concentration of Cd in the blood of subjects with osteoarthritis of the spine was significantly higher (p < 0.05) than that in the control group. Significantly lower (p < 0.05) median molar ratios of Ca to Cd and Pb as well as Mg to Pb and Cd were observed among patients with osteoarthritis of the spine. Significant differences (p < 0.05) were observed in the value of the fat/water ratio in selected spinal structures, depending on normal or abnormal serum Ca and Mg concentrations. The study showed some abnormal macronutrient concentrations, as well as disturbed ratios of beneficial elements to toxic elements in the blood of people with osteoarthritis of the spine.

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Section: Discussionsupporting

confidence: 55%

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Jakoniuk

Kochanowicz

Lankau

et al. 2022

IJERPH

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“…Regarding smoking, intervertebral disc cells experience disruption to their normal metabolic activities when exposed directly to soluble smoking gene toxin, which can disseminate through the vascular system or vertebral endplate (26). Several studies have shown that smoking is a key factor causing sciatica, LBP, and intervertebral disc degeneration and has a significant dose-dependent relationship with smoking (27)(28)(29)(30). Furthermore, Shady et al also demonstrated two mechanisms of nicotine-induced disc herniation using the finite-element method: nicotine-mediated downregulation of cell proliferation and anabolism and reduction of blood flow of blood vessels around the intervertebral disc due to vasoconstriction (31).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for lumbar disc herniation in adolescents and young adults: A case–control study

Luo

Meng

et al. 2023

Front. Surg.

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BackgroundThere is a limited understanding of the risk factors for lumbar disc herniation (LDH) in younger people, even though the evidence suggests that LDH is more prevalent in this population. This study aimed to comprehensively analyze the risk factors for LDH in adolescents and young adults.MethodsThe medical records of all patients were retrospectively reviewed with inclusion criteria of being younger than 25 years. Magnetic resonance imaging (MRI) was used to confirm LDH from September 2016 to September 2021. Furthermore, 104 healthy people in the same age range were enrolled as the control group from physical examination centers. Gender, BMI, smoking, drinking, genetic history, sitting posture, daily sitting time, traumatic history of the lower back, scoliosis, and daily exercise time were examined for all enrolled people. These factors were statistically analyzed to determine the high-risk factors.ResultsA total of 208 young individuals were enrolled in the present study. The mean age of the study group and the control group was 21.06 ± 3.27 years (range: 11–25 years) and 21.26 ± 2.23 years (range: 15–25 years), respectively. The result of the chi-squared test demonstrated that there was a significant difference in BMI of more than 30 (p < 0.001), genetic history (p = 0.004), sitting posture (p < 0.001), daily sitting time of more than 6 h (p < 0.001), and the history of low back trauma (p = 0.002). Additionally, multivariate logistic regression showed that these were high-risk factors for LDH, particularly the duration of daily sitting time (more than 6 h).ConclusionsBMI of more than 30, genetic history, sitting posture, daily sitting time of more than 6 h, and a history of low back trauma are the high-risk factors for adolescents and young adults with LDH. Therefore, providing them with the proper guidance and education, particularly about the protection of the lower back and the reduction of spinal load, could play a key role in preventing and reducing LDH.

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Facetteninfiltration und periradikuläre Therapie

Mack

Regier²,

Herzog³

2020

Radiologe

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Magnetic resonance imaging evaluation of the effects of cigarette and maras powder (smokeless tobacco) on lumbar disc degeneration

Cited by 7 publications

References 15 publications

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Risk factors for lumbar disc herniation in adolescents and young adults: A case–control study

Facetteninfiltration und periradikuläre Therapie

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