Magnetic resonance imaging evaluation of small intestinal Crohn's disease

Gourtsoyiannis, Nicholas; Papanikolaou, Nikolaos; Karantanas, Apostolos H.

doi:10.1016/j.bpg.2005.09.002

Cited by 75 publications

(55 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…multidetector-row computed tomography (MDCT) [1,2,3,4,5,6] and magnetic resonance imaging (MRI) [7,8,9,10,11,12,13,14,15], since these techniques allow for simultaneous visualization of luminal, mural and extraintestinal disease extension. …”

Section: Introductionmentioning

confidence: 99%

Acute Complications of Crohn’s Disease: Comparison of Multidetector-Row Computed Tomographic Enterography with Magnetic Resonance Enterography

Schmidt

Guibal²,

Meuwly³

et al. 2010

Digestion

View full text Add to dashboard Cite

Objective: To compare multidetector-row computed tomographic (MDCT) enterography with magnetic resonance (MR) enterography performed upon acute exacerbation of Crohn’s disease. Subjects and Methods: Fifty-seven patients (mean age 33.5) with proven Crohn’s disease and symptoms suggesting acute exacerbation were prospectively included. After oral administration of 1–2 liters of 5% methylcellulose, MDCT and MR enterography were performed on each patient (mean delay <24 h). Three radiologists blindly and independently evaluated each examination for technical quality and in terms of 8 pathological features of Crohn’s disease. Observers’ agreement, sensitivity and specificity resulted from comparison with the reference standard [surgery (n = 24), endoscopy (n = 17) and long-term follow-up (n = 16)]. Results: MDCT enterography demonstrated fewer artifacts than MR enterography (p < 0.0001). In 48 MDCT/MR enterography examinations, active disease was demonstrated: abscesses (n = 11), fistulas (n = 13), stenoses (n = 23) and/or intestinal inflammation (n = 38). Observers’ agreement (range 0.56–0.87) was not significantly different between MDCT and MR enterography, neither in terms of sensitivity (range 58–95%) nor specificity (range 67–100%) for each of the 8 pathological features. Conclusion: Statistically, MR enterography is of similar diagnostic value as MDCT enterography for acute complications of Crohn’s disease. Since the typical Crohn’s disease patient is young and will very likely undergo life-long imaging, and given concerns about radiation exposure with MDCT, MR enterography should be the preferred modality.

show abstract

Section: Introductionmentioning

confidence: 99%

Acute Complications of Crohn’s Disease: Comparison of Multidetector-Row Computed Tomographic Enterography with Magnetic Resonance Enterography

Schmidt

Guibal²,

Meuwly³

et al. 2010

Digestion

View full text Add to dashboard Cite

show abstract

“…In recent years, MRI has proven to be a reliable method in the diagnosis and follow-up of Crohn's disease, both in pediatric patients that adults and several data about imaging in MR have been pro-posed as "imaging biomarkers" of Crohn's disease activity [18,25]. It is known that some of these imaging features were already validated and correlated with histological examination of surgical specimens.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performances of Diffusion-Weighted Magnetic Resonance Imaging in the Evaluation of Fibrosis and Post-Operative Endoscopic Recurrence in Crohn’s Disease

Samperi¹

2016

GHOA

View full text Add to dashboard Cite

Background: Diffusion-weighted represents a new application of magnetic resonance imaging (DW-MRI) to assess inflammatory activity in Crohn's disease. ADC is a quantitative parameter of this phenomenon. We aimed to verify the correlation between DWI findings both with pathological evaluation of fibrosis in surgical specimen both with endoscopic recurrence.Methods: 31 pts undergoing ileocolonic resection for CD were submitted to DW-MRI. Conventional MRI findings of terminal or neo-terminal ileum were recorded together with a semiquantitative evaluation of DWI signal intensity and with ADC calculation. For the first aim, Acute Inflammatory (AIS) and Fibrostenosis score was correlated to ADC values of matched ileo-cecal segment. ROC curves analysis was used to find out an ADC cut-off value able to distinguish "low and high grade" severity of post-operative recurrence. Results:Comparison of DWI findings with surgical specimens pathologic evaluation showed a very good correlation, inverse and statistically significant, between ADC and AIS total (r=-0.90, p=0.013). The mean ADC value of the 5 pts with fibrosis was not statistically different from the 5 pts without. The comparison between ADC and Rutgeerts'score showed a good correlation, inverse and statistically significant (rho= -0.73, P=0.002). ROC curves analysis highlighted that a value of ADC ≤ 1.82 x10 -3 mm 2 /s could predict a severe recurrence (Rs >i2) with a sensitivity of 88.9% and a specificity of 83.3%. Conclusion:This study showed the ability of DWI sequences to provide quantitative measures of inflammation, allowing a more objective assessment of CD. Further studies should clarify whether ADC evaluation could predict the presence of fibrosis in surgical specimens.

show abstract

“…12 In particular, specific findings on MRI have been proposed as accurate markers of disease activity, for example mural signal characteristics and contrast enhancement patterns (Fig 2). 13 Small bowel distension for MR studies is most commonly achieved by oral administration of locust bean gum (extracted from the seeds of the carob tree) or mannitol 40 minutes prior to scanning.…”

Section: Small Bowel Magnetic Resonance Imagingmentioning

confidence: 99%

Imaging the gastrointestinal tract in 2008

2009

View full text Add to dashboard Cite

The plain abdominal X-ray is an important first-line investigation for some suspected acute gastrointestinal disorders, notably perforation and bowel obstruction Although barium studies continue to be the mainstay of luminal imaging, they are in part being replaced by new cross-sectional techniquesComputed tomographic colonography is evolving as a superior alternative to barium enema for imaging the colon Improved magnetic resonance technology, coupled with its non-use of ionising radiation, has markedly increased its role in imaging of the small and large bowel, particularly in the young population with chronic diseaseUltrasound is a readily available imaging modality which is useful in depicting the terminal ileum, appendix and collections Key PointsKEY WORDS: barium, computed tomographic colonography, magnetic resonance imaging, plain abdominal X-ray, ultrasound

show abstract

Magnetic resonance imaging evaluation of small intestinal Crohn's disease

Cited by 75 publications

References 36 publications

Acute Complications of Crohn’s Disease: Comparison of Multidetector-Row Computed Tomographic Enterography with Magnetic Resonance Enterography

Acute Complications of Crohn’s Disease: Comparison of Multidetector-Row Computed Tomographic Enterography with Magnetic Resonance Enterography

Diagnostic Performances of Diffusion-Weighted Magnetic Resonance Imaging in the Evaluation of Fibrosis and Post-Operative Endoscopic Recurrence in Crohn’s Disease

Imaging the gastrointestinal tract in 2008

Contact Info

Product

Resources

About