Magnetic Resonance Imaging Evaluation of Bone Metastases Treated with Radiotherapy in Palliative Intent: A Multicenter Prospective Study on Clinical and Instrumental Evaluation Assessment Concordance (MARTE Study)

Abstract

Metastasis to bone is a common occurrence among epithelial tumors, with a high incidence rate in the Western world. As a result, bone lesions are a significant burden on the healthcare system, with a high morbidity index. These injuries are often symptomatic and can lead to functional limitations, which in turn cause reduced mobility in patients. Additionally, they can lead to secondary complications such as pathological fractures, spinal cord compression, hypercalcemia, or bone marrow suppression. The treatment of bone metastases requires collaboration between multiple healthcare professionals, including oncologists, orthopedists, neurosurgeons, physiatrists, and radiotherapists. The primary objective of this study is to evaluate the correlation between two methods used to assess local control. Specifically, the study aims to determine if a reduction in the volume of bone lesions corresponds to better symptomatic control in the clinical management of patients, and vice versa. To achieve this objective, the study evaluates morphological criteria by comparing pre- and post-radiotherapy treatment imaging using MRI and RECIST 1.1 criteria. MRI without contrast is the preferred diagnostic imaging method, due to its excellent tolerance by patients, the absence of exposure to ionizing radiation, and the avoidance of paramagnetic contrast media side effects. This imaging modality allows for accurate assessment of bone lesions. One of the secondary objectives of this study is to identify potentially useful parameters that can distinguish patients into two classes: “good” and “poor” responders to treatment, as reported by previous studies in the literature. These parameters can be evaluated from the imaging examinations by analyzing morphological changes and radiomic features on different sequences, such as T1, STIR (short tau inversion recovery), and DWI-MRI (diffusion-weighted).

A comparative study of spinal cord compression management in metastatic prostate cancer: Teaching versus non‐teaching hospitals in the United States

“…Bone metastases are a common complication of patient with prostate cancer, occurring in over 90% of patients over disease course 6 . Bone metastases are detected through a variety of imaging techniques including MRI, CT, and PET scans 7,8 . In patients with bone metastases, complications are often collectively referred to as skeletal‐related events (SRE), which include pathologic fractures, the need for radiation or surgery, or spinal cord compression 9 .…”

“… 6 Bone metastases are detected through a variety of imaging techniques including MRI, CT, and PET scans. 7 , 8 In patients with bone metastases, complications are often collectively referred to as skeletal‐related events (SRE), which include pathologic fractures, the need for radiation or surgery, or spinal cord compression. 9 The most feared SRE is cord compression, occurring in approximately 9% of admissions related to skeletal‐related‐events.…”