Magnetic Resonance Imaging Evaluation of Patellar Tendon Graft Remodelling after Anterior Cruciate Ligament Reconstruction with or without Platelet-Rich Plasma

Abstract

purpose. To evaluate the stages of patellar tendon graft remodelling using magnetic resonance imaging (MRI) after anterior cruciate ligament (ACL) reconstruction with or without platelet-rich plasma (PRP) injection. Methods. 98 patients aged 18 to 65 years with complete rupture of the ACL were randomised to undergo reconstruction with the autologous patellar tendon grafts with or without PRP injection. For the PRP group, 8 ml of PRP was obtained in the surgery room and was percutaneously injected into the suprapatellar joint after portal suture. MRI was obtained at months 4, 6, and 12. Remodelling stages of the grafts were classified as hypointense, mildly hyperintense, moderately hyperintense, severely hyperintense, and diffusely hyperintense by a radiologist blinded to treatment allocation. results. More patients in the PRP group than controls attained higher stages of remodelling at month 4 (p=0.003), month 6 (p=0.0001), and month 12 (p=0.354). conclusion. PRP enabled faster remodelling of patellar tendon grafts.

Are Applied Growth Factors Able to Mimic the Positive Effects of Mesenchymal Stem Cells on the Regeneration of Meniscus in the Avascular Zone?

“…Beneficial effects by clinical use of PRP were seen in treatment of rotator cuff tears [9], Achilles tendon ruptures [22], chronic tendinosis [23], muscle injuries [7], ACL-rupture [12], and cartilage defects [11, 24]. …”

“…Depending on the different ways of preparation, PRP provides a huge variety of multiple growth factors [8]. In clinical use, PRP already showed promising results for the regeneration of different tissue types like rotator cuff [9] and cartilage [10, 11] and for enhanced healing during ligament reconstruction [12]. Positive effects on meniscal healing also seem to be possible.…”

RETRACTED ARTICLE: Comparison of double-bundle anterior cruciate ligament reconstruction with and without autologous conditioned serum application

“…Biological signalling proteins are the driving force behind growing number of groups working on the use of platelet-rich plasma (PRP) as an adjunct treatment after surgery [19,29,34,35,40]. However, it is noteworthy that recent articles appear not to have found bone tunnel widening reduction with PRP [29,39].…”

Arthroscopic double row cuff repair with suture-bridging and autologous conditioned plasma injection: Functional and structural results

“…Indeed, the beneficial effect of APC injections in tendon surgical repair has been shown in several studies, and could have potential applications in many fields in orthopedic surgery (Reconstruction of anterior cruciate ligament,[ 22 ] tendon surgery, treatment of joint injuries,[ 23 24 ] tendinopathy[ 25 ] or muscle tears). Mishra et al .…”