“…Patient were candidates for cement augmentation if they had a VCF with at least 20% loss of anterior or middle vertebral body height and persistent pain not related to other causes as determined by the clinical exam, and imaging (e.g., discogenic or fascetogenic pain); the pain level should have been at least 4/10 on a numerical scale, and not responsive for at least 2 weeks to conventional medical therapy, including narcotic analgesics, bracing, physical therapy, and bed rest. Symptoms had to be localized to the index vertebral body, and MRI (STIR sequence) was used to confirm the presence of edema in the fractured vertebra(e), which implied an acute or non healed state [16]. However, due to multi-level bone marrow involvement in the majority of cases, we frequently performed prophylactic augmentation in the adjacent vertebrae, especially in the thoracolumbar junction, to avoid subsequent fractures.…”