Magnetic resonance imaging findings in corticobasal degeneration

Involvement of motor pathways in corticobasal syndrome detected by diffusion tensor tractography

“…We note the histopathological investigation of Dickson et al supports our finding that the greatest severity of white matter degeneration is contralateral to the side of motor onset 35. Imaging results demonstrating a CST involvement in CBS are rare, but subcortical hyperintensities within the precentral gyrus have been found on T2‐weighted MR images assuming a focal demyelination or gliosis 19. MR spectroscopic imaging has shown a significant reduced metabolism in the centrum semiovale 18.…”

“…Tedeschi and colleagues have demonstrated that white matter is affected in CBS showing a significant reduction of the ratio of N ‐acetyl‐aspartate to creatine in the centrum semiovale 18. Winkelmann et al have described hyperintense signal changes in the subcortical white matter on T2‐weighted images in two patients that match the corticospinal tract (CST) 19. Others, however, failed to demonstrate such signal abnormalities 7.…”

An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism

“…Only a few studies have investigated the role of cMRI in patients with corticobasal degeneration, showing cortical especial frontoparietal atrophy, which usually seems to be asymmetric, and putaminal hypointensity as well as hyperintense signal changes in the motor cortex or subcortical white matter on T2-weighted images [22,28,38,42,43]. Recently, the Mayo Clinic Electronic Records Database was used to review 40 autopsy cases presenting with the clinical diagnosis of a corticobasal syndrome during life, including corticobasal degeneration and other neurodegenerative causes such as PSP and frontotemporal degenerations, and having at least one MRI examination with both axial T1-and T2-weighted and sagittal T1-weighted images [44 ].…”

MRI of progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy

“…The former includes asymmetric frontoparietal atrophy [32,35], especially in the parasagittal region [28,33]. The latter involves white matter hyperintensities on T2-weighted MRI (T2WI) [8,40]. However, whether these findings are pathognomonic for CBD or not remains controversial.…”