Magnetic resonance imaging for acute pancreatitis in type 2 diabetes patients

Ni, Yan-Hui; Song, Ling-Ji; Xiao, Bo

doi:10.12998/wjcc.v11.i30.7268

World J Clin Cases

2023

DOI: 10.12998/wjcc.v11.i30.7268

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Magnetic resonance imaging for acute pancreatitis in type 2 diabetes patients

Yan-Hui Ni,

Ling-Ji Song,

Bo Xiao

Abstract: Rehabilitation of lower limb amputation in developing countries is quite challenging. Though there are basic to highly advanced prostheses available in India, the set-up is still facing difficulties in developing countries. Prosthetic management is difficult due to lack of availability of prostheses and reduced affordability among low income populations. In this review we highlighted the lower limb amputation and prosthetic rehabilitation status in India. Currently, India is advancing well in the rehabilitatio… Show more

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Association between diabetic status and risk of acute pancreatitis: A nationwide population‐based study

Chung,

Cho,

Choi

et al. 2024

J Evidence Based Medicine

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ObjectiveThere have been several epidemiologic studies on the association between diabetes mellitus and acute pancreatitis. However, there is no solid evidence, and the effect of diabetes mellitus severity on acute pancreatitis incidence is not well known. This study aimed to evaluate the association between diabetic status and the risk of acute pancreatitis in a nationwide population‐based cohort.MethodsAmong the participants who underwent national health examinations between 2009 and 2012, patients with diabetes mellitus were included. Patients diagnosed with acute pancreatitis before the health examination or diagnosed with pancreatitis within 1 year following the examination were excluded. The association between the number of oral hypoglycemic agents (<3 or ≥3) or insulin use during examination and acute pancreatitis occurrence was analyzed after follow‐up until December 31, 2018.ResultsOverall, 2,444,254 patients were included in the final analysis. During the follow‐up period, acute pancreatitis occurred in 10,360 patients with an incidence ratio of 0.585 per 1,000 person‐years, and it was observed that the risk of acute pancreatitis sequentially increased between patients taking oral hypoglycemic agents <3 (incidence ratio = 0.546), those taking ≥3 (incidence ratio = 0.665), and those using insulin (incidence ratio = 0.872). The adjusted hazard ratios of patients taking three or more hypoglycemic agents and those using insulin were 1.196 (95% confidence interval (CI) 1.123–1.273) and 1.493 (95% CI 1.398–1.594), respectively.ConclusionsAs diabetes mellitus severity increases, the risk of acute pancreatitis increases.

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Association between diabetic status and risk of acute pancreatitis: A nationwide population‐based study

Chung,

Cho,

Choi

et al. 2024

J Evidence Based Medicine

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Plantamajoside improves type 2 diabetes mellitus pancreatic β-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation

Wang,

Zhao

et al. 2025

World J Diabetes

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BACKGROUND Plantamajoside (PMS) has shown potential in mitigating cell damage caused by high glucose (HG) levels. Despite this, the precise therapeutic effects of PMS on type 2 diabetes mellitus (T2DM) and the underlying regulatory mechanisms require further exploration. AIM To investigate PMS therapeutic effects on T2DM in mice and elucidate its mechanisms of action through in vivo and in vitro experiments. METHODS An in vitro damage model of MIN6 cells was established using HG and palmitic acid (PA). PMS's protective effect on cell damage was assessed. Next, transcriptomics was employed to examine how PMS treatment affects gene expression of MIN6 cells. Furthermore, the effect of PMS on protein processing in endoplasmic reticulum and apoptosis pathways was validated. A T2DM mouse model was used to validate the therapeutic effects and mechanisms of PMS in vivo . RESULTS PMS intervention ameliorated cell injury in HG + PA-induced MIN6 cell damage. Transcriptomic analysis revealed that protein processing in the endoplasmic reticulum and apoptosis pathways were enriched in cells treated with PMS, with significant downregulation of the gene Dnajc1. Further validation indicated that PMS significantly inhibited the expression of apoptosis-related factors (Bax, CytC) and endoplasmic reticulum stress (ERS)-related factors [ATF6, XBP1, Ddit3 (CHOP), GRP78], while promoting the expression of Bcl-2 and Dnajc1. Additionally, the inhibitory effects of PMS on ERS and apoptosis were abolished upon Dnajc1 silencing. Furthermore, in vivo experiments demonstrated that PMS intervention effectively improved pancreatic damage, suppressed the expression of apoptosis-related factors (Bax, CytC), and ERS-related factors [ATF6, XBP1, Ddit3 (CHOP), GRP78], while promoting the expression of Bcl-2 and Dnajc1 in a T2DM model mice. CONCLUSION PMS intervention could alleviate pancreatic tissue damage effectively. The mechanism of action involves Dnajc1 activation, which subsequently inhibits apoptosis and ERS, ameliorating damage to pancreatic β-cells.

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Magnetic resonance imaging for acute pancreatitis in type 2 diabetes patients

Cited by 2 publications

References 36 publications

Association between diabetic status and risk of acute pancreatitis: A nationwide population‐based study

Association between diabetic status and risk of acute pancreatitis: A nationwide population‐based study

Plantamajoside improves type 2 diabetes mellitus pancreatic β-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation

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