Magnetic resonance imaging for distinguishing ovarian clear cell carcinoma from high-grade serous carcinoma

Abstract

BackgroundTo compare the magnetic resonance imaging (MRI) features of ovarian clear cell carcinoma (CCC) and high-grade serous carcinoma (HGSC), to distinguish CCC from HGSC.MethodsMRI features (laterality, shape, size, configuration, papillary projection, signal intensity, enhancement, peritoneal implant, lymphadenopathy, ascites) of 40 tumors in 37 patients with CCC, confirmed by surgery and pathology, were compared with those of 62 tumors in 40 patients with HGSC. Statistical analysis was performed using Mann-Whitney and Fisher’s exact tests.ResultsThere was a statistically significant difference in the mean maximum diameter, laterality, and FIGO stage (P = 0.002, P < 0.001, P < 0.001, respectively) between CCC and HGSC. Compared to HGSCs, CCCs were more frequently oval (30/40, 75 % vs 12/62, 19 %; P < 0.001), more often cystic (21/40, 53 % vs 8/62, 13 %; P < 0.001) and unilocular (23/29, 79 % vs 7/31, 23 %; P < 0.001), had T1-hyperintense cystic components more often (18/29, 62 % vs 5/29, 17 %; P < 0.001), had larger papillary projections (5.13 ± 0.4 cm vs 2.91 ± 0.3 cm; P < 0.001), were peritoneally implanted less frequently (P = 0.001) and had fewer ascites (P < 0.001).ConclusionsCCC typically showed an oval, unilocular cystic mass with large papillary projection and T1-hyperintense cystic components. MRI could be helpful for distinguishing CCC from HGSC.

Magnetic resonance imaging in categorization of ovarian epithelial cancer and survival analysis with focus on apparent diffusion coefficient value: correlation with Ki-67 expression and serum cancer antigen-125 level

“…The possible reason may be that Type II cancer comprised of only one pathological subtype, while there were four subtypes identified in Type I OEC patients resulting in much heterogeneity in the lesion. Also, previous research found that hyperintense cystic components were often detected on T1WI in clear cell and endometroid ovarian cancer than in other subtypes [29, 30]. These findings are supported by our study.…”

Apparent diffusion coefficients measured using different regions of interest in differentiating borderline from malignant ovarian tumors

“…These results are in line with those of previous studies (17). In addition, a previous study demonstrated that ADC value is helpful for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma (25). As the pathological subtypes were relatively small, further investigation focused on discriminating different types of BOTs and MOTs using ADC values is warranted.…”

Constructing an ovarian cancer metastasis index by dissecting medical records

“…In the clinic, functional magnetic resonance imaging (MRI) is a preferred choice for diagnosis and evaluation of OC [ 37 ], and both ascites, as well as laterality, can be recognized as features from an MRI image. Ma et al compared the features of ovarian clear cell carcinoma and high-grade serous carcinoma, which included ascites and laterality [ 38 ]. Despite the authors emphasizing the consistency of MRI and intraoperative examinations, no performance evaluation data such as accuracy was provided.…”