Magnetic Resonance Imaging in the Clinical Diagnosis of Creutzfeldt-Jakob Disease

Abstract

These results indicate that MRI is a useful and valuable tool with reasonable sensitivity (67%) and high specificity (93%) and should be considered as an additional cornerstone in the clinical diagnosis of CJD.

MRI and clinical syndrome in dura materrelated Creutzfeldt-Jakob disease

“…In sCJD, six molecular types (codon 129 genotype + PrP Sc type 1 or 2; MM1, MM2, MV1, MV2, VV1, VV2) have been described with various clinical and diagnostic findings [42,43]. Basal ganglia and cortical signal increase are most frequently found on the MRI [44][45][46][47][48]. Thalamic signal increase represents a comparatively rare finding, which seems to largely depend on the application of DW images [45][46][47][48].…”

“…Basal ganglia and cortical signal increase are most frequently found on the MRI [44][45][46][47][48]. Thalamic signal increase represents a comparatively rare finding, which seems to largely depend on the application of DW images [45][46][47][48].…”

MR Imaging of Familial Creutzfeldt-Jakob Disease: A Blinded and Controlled Study

“…50,51 Most studies of larger numbers of CJD subjects have a small percentage of cases that are negative on MR imaging. 21,22,52 There are several possible explanations for the false-negative MR results. As noted above, imaging findings can evolve during the course of the disease, 8,11 suggesting that serial imaging is important if the initial MR examination is negative.…”

Risikofaktoren der sporadischen Creutzfeldt-Jakob-Krankheit

“…Sie zeichnet sich jedoch als sensitive (67%) und hoch spezifische (93%) diagnostische Zusatzuntersuchung aus (Schröter et al 2000). Typisch für die sCJK sind bilaterale symmetrische hyperintense Basalganglien sowie Signalanhebungen im Kortex und Thalamus, die vor allem in der Diffusions-und Protonen-Dichte-Wichtung, aber auch in der T2-und FLAIR-Wichtung ("Fluid-Attenuated-Inversion-Recovery") sichtbar werden (Finkenstaedt et al 1996, Schröter et al 2000, Kallenberg et al 2006). …”