Magnetic resonance imaging in the diagnosis of breast disease: use of transverse relaxation times.

McSweeney, M. B.; Small, William; Černý, Vladimír; Sewell, W; Powell, Rachel; Goldstein, J. H.

doi:10.1148/radiology.153.3.6093191

Cited by 42 publications

(16 citation statements)

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“…The question also arises whether our findings are consistent with previous relaxation measurements of breast tissue (2,5,6,27,28) or adipose tissue (16,29). Such comparisons are confounded by differences in the magnetic field strength and temperature at which measurements were performed (both influence T, and T, relaxation times) and by the methods by which relaxation times are measured and estimated.…”

Section: Discussionsupporting

confidence: 87%

“…At present, the MR properties of normal and pathological breast tissue have been incompletely characterized, partly because breast tissue is a heterogeneous mixture of adipose and fibroglandular tissue at both macroscopic and microscopic resolution. Techniques to analyze and interpret measurements of MR relaxation times have improved significantly, however, since the T , and T, relaxation properties of breast tissue were last investigated extensively (5,6). Algorithms that interpret relaxation data in terms of continuous distributions of relaxation times, such as T2NNLS (7), provide a more realistic model of tissue heterogeneity than that previously provided by fits of relaxation data to a sum of several exponentials (8).…”

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance properties of ex vivo breast tissue at 1.5 T

Graham

Ness

Hamilton

et al. 1997

Magnetic Resonance in Med

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The magnetic resonance absorption spectrum, T1 and T2 relaxation time distributions, and magnetization transfer properties of ex vivo breast tissue have been characterized at 1.5 T and 37 degrees C. The fraction of fibroglandular tissue within individual tissue samples (n = 31) was inferred from the tissue volumetric water content obtained by integration of resolvable broad-line fat and water resonances. The spectroscopically estimated water content was strongly correlated with that extracted enzymatically (Pearson correlation coefficient 0.98, P < < 0.01), which enabled the assignment of principal relaxation components for fibroglandular tissue (T2=0.04+/-0.01, T1=1.33+/-0.24 s), and for adipose tissue (T2=0.13+/-0.01, T1=0.23+/-0.01 s, and T2=0.38+/-0.03, T1=0.62+/-0.16 s). Th e relaxation components for fibroglandular tissue exhibited strong magnetization transfer, whereas those for adipose tissue showed little magnetization transfer effect. These results ultimately have applicability to the optimization of clinical magnetic resonance imaging and research investigations of the breast.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Magnetic resonance properties of ex vivo breast tissue at 1.5 T

Graham

Ness

Hamilton

et al. 1997

Magnetic Resonance in Med

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“…Diffusion‐weighted imaging is routinely employed in breast MRI as a quantitative measure of tissue cellularity, while dynamic contrast‐enhanced MRI is primarily used as a semiquantitative perfusion technique in breast imaging. Measurement of T 1 and T 2 relaxation times can provide additional information about normal and diseased breast tissue . Previous studies on breast relaxometry have observed significant differences in T 1 and T 2 relaxation times between normal fibroglandular breast tissue and benign and malignant breast tumors .…”

mentioning

confidence: 99%

“…Measurement of T 1 and T 2 relaxation times can provide additional information about normal and diseased breast tissue. 4,5 Previous studies on breast relaxometry have observed significant differences in T 1 and T 2 relaxation times between normal fibroglandular breast tissue and benign and malignant breast tumors. 5,6 Changes in T 2 relaxation time has also been used to characterize response to chemotherapy in breast cancers.…”

mentioning

confidence: 99%

Repeatability and reproducibility of 3D MR fingerprinting relaxometry measurements in normal breast tissue

Panda

Chen

Ropella-Panagis

et al. 2019

Magnetic Resonance Imaging

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Background The 3D breast magnetic resonance fingerprinting (MRF) technique enables T1 and T2 mapping in breast tissues. Combined repeatability and reproducibility studies on breast T1 and T2 relaxometry are lacking. Purpose To assess test–retest and two‐visit repeatability and interscanner reproducibility of the 3D breast MRF technique in a single‐institution setting. Study Type Prospective. Subjects Eighteen women (median age 29 years, range, 22–33 years) underwent Visit 1 scans on scanner 1. Ten of these women underwent test–retest scan repositioning after a 10‐minute interval. Thirteen women had Visit 2 scans within 7–15 days in same menstrual cycle. The remaining five women had Visit 2 scans in the same menstrual phase in next menstrual cycle. Five women were also scanned on scanner 2 at both visits for interscanner reproducibility. Field Strength/Sequence Two 3T MR scanners with the 3D breast MRF technique. Assessment T1 and T2 MRF maps of both breasts. Statistical Tests Mean T1 and T2 values for normal fibroglandular tissues were quantified at all scans. For variability, between and within‐subjects coefficients of variation (bCV and wCV, respectively) were assessed. Repeatability was assessed with Bland–Altman analysis and coefficient of repeatability (CR). Reproducibility was assessed with interscanner coefficient of variation (CoV) and Wilcoxon signed‐rank test. Results The bCV at test–retest scans was 9–12% for T1, 7–17% for T2, wCV was <4% for T1, and <7% for T2. For two visits in same menstrual cycle, bCV was 10–15% for T1, 13–17% for T2, wCV was <7% for T1 and <5% for T2. For two visits in the same menstrual phase, bCV was 6–14% for T1, 15–18% for T2, wCV was <7% for T1, and <9% for T2. For test–retest scans, CR for T1 and T2 were 130 msec and 11 msec. For two visit scans, CR was <290 msec for T1 and 10–14 msec for T2. Interscanner CoV was 3.3–3.6% for T1 and 5.1–6.6% for T2, with no differences between interscanner measurements (P = 1.00 for T1, P = 0.344 for T2). Data Conclusion 3D breast MRF measurements are repeatable across scan timings and scanners and may be useful in clinical applications in breast imaging. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1133–1143.

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“…T2WI are typically used to identify and characterize cysts. Typical breast carcinomas have shorter T2 relaxation times and display lower signal intensity (SI) on T2WI than benign lesions (16, 17). However, many benign lesions and some carcinomas, including mucinous (colloid) carcinomas (18), have a long T2 relaxation time and are occasionally difficult to distinguish from cysts on T2WI alone.…”

mentioning

confidence: 99%

Breast carcinomas with strong high‐signal intensity on T2‐weighted MR images: Pathological characteristics and differential diagnosis

Yuen

Uematsu

Kasami

et al. 2007

Magnetic Resonance Imaging

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Purpose:To investigate the histopathological characteristics of breast carcinomas with strong high-signal intensity (SHi) on T2-weighted (T2W) MR images (T2-SHi), and discuss the differential diagnosis between T2-SHi breast carcinomas and T2-SHi fibroadenomas. Materials and Methods:Thirty of 480 breast carcinomas examined by MRI were defined as tumors with T2-SHi (defined as homogeneous higher signal intensity (SI) compared to surrounding normal breast tissue on fat-suppressed T2W imaging (T2WI). They included eight mucinous and 22 nonmucinous carcinomas. The histopathological characteristics of T2-SHi breast carcinomas, their signal-to-noise ratios (SNRs) on T2WI, contrast-enhancement patterns, and morphology were compared with those of 22 non-T2-SHi breast carcinomas and 19 T2-SHi fibroadenomas. Results:In nonmucinous carcinomas T2-SHi was attributable to a mixture of background matrix, a higher proportion of cells than stroma, abundant cytoplasm, edematous stroma, and hemorrhage. The significantly high SNR (mean ϭ 75) and enhancing internal septations seen in mucinous carcinomas, and the washout phenomenon, irregular border, absence of internal septation, and rim enhancement seen in nonmucinous carcinomas provide useful information for differentiating these tumors from T2-SHi fibroadenomas. Conclusion:A mixture of several histopathological characteristics was associated with T2-SHi breast carcinomas. The combined information from T2WI and contrast-enhanced (CE) imaging may help distinguish T2-SHi breast carcinomas from T2-SHi fibroadenomas. BREAST MRI is now widely used to diagnose and characterize suspected breast lesions identified by mammography and ultrasonography. Contrast-enhanced (CE) breast MRI has a high sensitivity (approximately 90%) but lower specificity (37-86%) for detecting breast carcinoma (1-9). Attempts have been made to increase its specificity, and some studies have indicated that careful analysis of T2-weighted images (T2WI) can aid in establishing a differential diagnosis (10 -15).T2WI are typically used to identify and characterize cysts. Typical breast carcinomas have shorter T2 relaxation times and display lower signal intensity (SI) on T2WI than benign lesions (16,17). However, many benign lesions and some carcinomas, including mucinous (colloid) carcinomas (18), have a long T2 relaxation time and are occasionally difficult to distinguish from cysts on T2WI alone. The SI of fibroadenomas on T2WI, and the histopathological correlation have been analyzed. Myxoid and edematous fibroadenomas yield strong high-SI (SHi) on T2WI (T2-SHi) (19,20). However, few studies have examined the correlation between SI on T2WI and histopathology of carcinoma.Since it remains to be determined why some breast carcinomas other than mucinous carcinomas display T2-SHi, we investigated the histopathological characteristics of breast carcinomas with T2-SHi. We discuss the diagnostic utility of the combined information provided by T2-SHi and the enhancement patterns and morphology on CE images for differentiat...

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Magnetic resonance imaging in the diagnosis of breast disease: use of transverse relaxation times.

Cited by 42 publications

References 0 publications

Magnetic resonance properties of ex vivo breast tissue at 1.5 T

Magnetic resonance properties of ex vivo breast tissue at 1.5 T

Repeatability and reproducibility of 3D MR fingerprinting relaxometry measurements in normal breast tissue

Breast carcinomas with strong high‐signal intensity on T2‐weighted MR images: Pathological characteristics and differential diagnosis

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